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Ontogeny and Oncology

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Book cover Origin of Cancers

Part of the book series: Cancer Treatment and Research ((CTAR,volume 154))

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The expression oncology recapitulates ontogeny connotes that normality in one context may be anomaly in another.

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References

  1. Gal H, Amariglio N, Trakhtenbrot L et al (2006) Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells. Leukemia 20:2147–2154

    Article  CAS  PubMed  Google Scholar 

  2. Yang J, Mani SA, Donaher JL et al (2004) Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117:927–939

    Article  CAS  PubMed  Google Scholar 

  3. Chen Z-F, Behringer RR (1995) twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev 9:686–699

    Article  CAS  PubMed  Google Scholar 

  4. Puisieux A, Valsesia-Wittmann S, Ansieau S (2006) A twist for survival and cancer progression. Br J Cancer 94:13–17

    Article  CAS  PubMed  Google Scholar 

  5. Valsesia-Wittmann S, Magdeleine M, Dupasquier S et al (2004) Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells. Cancer Cell 6:625–630

    Article  CAS  PubMed  Google Scholar 

  6. Lee JS, Heo J, Libbrecht L et al (2006) A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 12:410–416

    Article  CAS  PubMed  Google Scholar 

  7. Liu H, Kho AT, Kohane IS et al (2006) Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development. PLoS Med 3:e232

    Article  PubMed  Google Scholar 

  8. Phillips HS, Kharbanda S, Chen R et al (2006) Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9:157–173

    Article  CAS  PubMed  Google Scholar 

  9. Morrison SJ, Kimble J (2006) Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441:1068–1074

    Article  CAS  PubMed  Google Scholar 

  10. Duesberg P, Fabarius A, Hehlmann R (2004) Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells. IUBMB Life 56:65–81

    Article  CAS  PubMed  Google Scholar 

  11. Sparmann A, van Lohuizen M (2006) Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6:846–856

    Article  CAS  PubMed  Google Scholar 

  12. Tarin D, Thompson EW, Newgreen DF (2005) The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 65:5996–6001

    Article  CAS  PubMed  Google Scholar 

  13. Thompson EW, Newgreen DF, Tarin D (2005) Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res 65:5991–5995

    Article  CAS  PubMed  Google Scholar 

  14. Hasan J, Byers R, Jayson GC (2002) Intra-tumoural microvessel density in human solid tumours. Br J Cancer 86:1566–1577

    Article  CAS  PubMed  Google Scholar 

  15. Toi M, Matsumoto T, Bando H (2001) Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications [review]. Lancet Oncol 2:667–673

    Article  CAS  PubMed  Google Scholar 

  16. Giantonio BJ, Catalano PJ, Meropol NJ et al (2007) Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 25:1539–1544

    Article  CAS  PubMed  Google Scholar 

  17. Hurwitz H, Fehrenbacher L, Novotny W et al (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335–2342

    Article  CAS  PubMed  Google Scholar 

  18. Miller K, Wang M, Gralow J et al (2007) Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357:2666–2676

    Article  CAS  PubMed  Google Scholar 

  19. Sandler A, Gray R, Perry MC et al (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542–2550, Erratum in N Engl J Med 2007;356(3):318

    Article  CAS  PubMed  Google Scholar 

  20. Vredenburgh JJ, Desjardins A, Herndon JE II et al (2007) Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 25:4722–4729

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Shi-Ming Tu .

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Tu, SM. (2010). Ontogeny and Oncology. In: Origin of Cancers. Cancer Treatment and Research, vol 154. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5968-3_9

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  • DOI: https://doi.org/10.1007/978-1-4419-5968-3_9

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-5967-6

  • Online ISBN: 978-1-4419-5968-3

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