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Bacterial Effectors: Learning on the Fly

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Recent Advances on Model Hosts

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 710))

Abstract

A common defining characteristic of pathogenic bacteria is the expression of a repertoire of effector molecules that have been named virulence factors. These bacterial factors include a ­variety of proteins, such as toxins that are internalized by receptors and translocate across endosomal membranes to reach the cytosol, as well as others that are introduced directly into the cell by means of bacterial secretory apparatuses. Given the importance of these effectors for understanding bacterial pathogenicity, significant effort has been made to dissect their molecular mechanisms of action and their respective roles during infection. Herein we will discuss how Drosophila have been used as a model system to study these important microbial effectors, and to understand their contribution to pathogenicity.

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Acknowledgments

We thank Emmanuel Lemichez for critical reading of the manuscript. LMS is supported by startup funds from MGHfC, MGH ECOR and grants from NIH/NIAID. NS is supported by grants from the NIH/NIAID (AI060025 and AI074958) and from BWF. NP is supported by a grant from the NIH (U54 AI057159). LB is supported by a fellowship from the Ligue Nationale Contre le Cancer.

Author information

Authors and Affiliations

  1. INSERM, U895, Centre Méditerranéen de Médecine Moléculaire, Toxines Microbiennes dans la relation hôte pathogènes, Cedex 3, F-06204, Nice, France

    Laurent Boyer

  2. Université de Nice-Sophia-Antipolis, UFR Médecine, Nice, France

    Laurent Boyer

  3. Developmental Immunology, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA

    Nicholas Paquette & Lynda M. Stuart

  4. Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA, 01605, USA

    Neal Silverman

Authors
  1. Laurent Boyer
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  2. Nicholas Paquette
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  3. Neal Silverman
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  4. Lynda M. Stuart
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Corresponding author

Correspondence to Laurent Boyer .

Editor information

Editors and Affiliations

  1. Massachusetts General Hospital, Harvard Medical School, Fruit Street 55, Boston, 02114-2696, Massachusetts, USA

    Eleftherios Mylonakis

  2. Massachusetts General Hospital, Harvard Medical School, Cambridge Street 185, Boston, 02114, Massachusetts, USA

    Frederick M. Ausubel

  3. Schepens Eye Research Inst., Harvard Medical School, Staniford St. 20, Boston, 02114, Massachusetts, USA

    Michael Gilmore

  4. Albert Einstein College of Medicine, Dept. Microbiology & Immunology, Yeshiva University, Morris Park Ave. 1300, Bronx, 10461, New York, USA

    Arturo Casadevall

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Boyer, L., Paquette, N., Silverman, N., Stuart, L.M. (2012). Bacterial Effectors: Learning on the Fly. In: Mylonakis, E., Ausubel, F., Gilmore, M., Casadevall, A. (eds) Recent Advances on Model Hosts. Advances in Experimental Medicine and Biology, vol 710. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5638-5_4

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