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Microbial Endocrinology pp 213–227Cite as

The Epinephrine/Norepinephrine/Autoinducer-3 Interkingdom Signaling System in Escherichia coli O157:H7

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Abstract

Epinephrine/norepinephrine/AI-3 signaling is used as an interkingdom chemical signaling system between microbes and their hosts. This system is also exploited by pathogens to regulate virulence traits. In enterohemorrhagic E. coli (EHEC) O157:H7, it is essential for pathogenesis and flagella motility. These three signals activate expression of a pathogenicity island named locus of enterocyte effacement (LEE), Shiga toxin, and the flagella regulon. These signals are sensed by the two-component system QseBC, whereas the bacterial membrane receptor QseC autophosphorylates and phosphorylates the QseB response regulator initiating a complex phosphorelay signaling cascade that activates the expression of a second two-component system, QseEF. The QseEF two-component system is also involved in the expression of the virulence genes, and it senses epinephrine, phosphate, and sulfate. This complex signaling cascade still needs to be completely elucidated.

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References

  • Barba, J., V. H. Bustamante, M. A. Flores-Valdez, W. Deng, B. B. Finlay, and J. L. Puente. A Positive Regulatory Loop Controls Expression of the Locus of Enterocyte Effacement-Encoded Regulators Ler and Grla. J Bacteriol 187, no. 23 (2005): 7918–30.

    Article  PubMed  CAS  Google Scholar 

  • Bearson, B. L., and S. M. Bearson. The Role of the Qsec Quorum-Sensing Sensor Kinase in Colonization and Norepinephrine-Enhanced Motility of Salmonella enterica Serovar Typhimurium. Microb Pathog 44, no. 4 (2008): 271–8.

    Article  PubMed  CAS  Google Scholar 

  • Boerlin, P., S. A. McEwen, F. Boerlin-Petzold, J. B. Wilson, R. P. Johnson, and C. L. Gyles. Associations between Virulence Factors of Shiga Toxin-Producing Escherichia coli and Disease in Humans. J Clin Microbiol 37, no. 3 (1999): 497–503.

    PubMed  CAS  Google Scholar 

  • Bustamante, V. H., F. J. Santana, E. Calva, and J. L. Puente. Transcriptional Regulation of Type Iii Secretion Genes in Enteropathogenic Escherichia coli: Ler Antagonizes H-Ns-Dependent Repression. Mol Microbiol 39, no. 3 (2001): 664–78.

    Article  PubMed  CAS  Google Scholar 

  • Campellone, K. G., D. Robbins, and J. M. Leong. Espfu Is a Translocated Ehec Effector That Interacts with Tir and N-Wasp and Promotes Nck-Independent Actin Assembly. Dev Cell 7, no. 2 (2004): 217–28.

    Article  PubMed  CAS  Google Scholar 

  • Charpentier, X., and E. Oswald. Identification of the Secretion and Translocation Domain of the Enteropathogenic and Enterohemorrhagic Escherichia coli Effector Cif, Using Tem-1 Beta-Lactamase as a New Fluorescence-Based Reporter. J Bacteriol 186, no. 16 (2004): 5486–95.

    Article  PubMed  CAS  Google Scholar 

  • Chen, X., S. Schauder, N. Potier, A. Van Dorssealaer, I. Pelczer, B.L. Bassler, and F.M. Hughson. Structural Identification of a Bacterial Quorum-Sensing Signal Containing Boron. Nature 415 (2002): 545–49.

    Article  PubMed  CAS  Google Scholar 

  • Cherezov, V., D. M. Rosenbaum, M. A. Hanson, S. G. Rasmussen, F. S. Thian, T. S. Kobilka, H. J. Choi, P. Kuhn, W. I. Weis, B. K. Kobilka, and R. C. Stevens. High-Resolution Crystal Structure of an Engineered Human Beta2-Adrenergic G Protein-Coupled Receptor. Science 318, no. 5854 (2007): 1258–65.

    Article  PubMed  CAS  Google Scholar 

  • Clarke, M. B., D. T. Hughes, C. Zhu, E. C. Boedeker, and V. Sperandio. The Qsec Sensor Kinase: A Bacterial Adrenergic Receptor. Proc Natl Acad Sci U S A 103, no. 27 (2006): 10420–5.

    Article  PubMed  CAS  Google Scholar 

  • Clarke, M. B., and V. Sperandio. Transcriptional Autoregulation by Quorum Sensing Escherichia coli Regulators B and C (Qsebc) in Enterohaemorrhagic E. coli (Ehec). Mol Microbiol 58, no. 2 (2005): 441–55.

    Article  PubMed  CAS  Google Scholar 

  • Clarke, M. B., and V. Sperandio. Transcriptional Regulation of Flhdc by Qsebc and Sigma (Flia) in Enterohaemorrhagic Escherichia coli. Mol Microbiol 57, no. 6 (2005): 1734–49.

    Article  PubMed  CAS  Google Scholar 

  • Deibel, C., S. Kramer, T. Chakraborty, and F. Ebel. Espe, a Novel Secreted Protein of Attaching and Effacing Bacteria, Is Directly Translocated into Infected Host Cells, Where It Appears as a Tyrosine-Phosphorylated 90 Kda Protein. Mol Microbiol 28, no. 3 (1998): 463–74.

    Article  PubMed  CAS  Google Scholar 

  • Deng, W., J. L. Puente, S. Gruenheid, Y. Li, B. A. Vallance, A. Vazquez, J. Barba, J. A. Ibarra, P. O’Donnell, P. Metalnikov, K. Ashman, S. Lee, D. Goode, T. Pawson, and B. B. Finlay. Dissecting Virulence: Systematic and Functional Analyses of a Pathogenicity Island. Proc Natl Acad Sci U S A 101, no. 10 (2004): 3597–602.

    Article  PubMed  CAS  Google Scholar 

  • DeVinney, R., A. Gauthier, A. Abe, and B. B. Finlay. Enteropathogenic Escherichia coli: A Pathogen That Inserts Its Own Receptor into Host Cells. Cell Mol Life Sci 55, no. 6–7 (1999): 961–76.

    PubMed  CAS  Google Scholar 

  • Donohue-Rolfe, A., G. T. Keusch, C. Edson, D. Thorley-Lawson, and M. Jacewicz. Pathogenesis of Shigella Diarrhea. I×. Simplified High Yield Purification of Shigella Toxin and Characterization of Subunit Composition and Function by the Use of Subunit-Specific Monoclonal and Polyclonal Antibodies. J Exp Med 160, no. 6 (1984): 1767–81.

    Article  PubMed  CAS  Google Scholar 

  • Elliott, S. J., V. Sperandio, J. A. Giron, S. Shin, J. L. Mellies, L. Wainwright, S. W. Hutcheson, T. K. McDaniel, and J. B. Kaper. The Locus of Enterocyte Effacement (Lee)-Encoded Regulator Controls Expression of Both Lee- and Non-Lee-Encoded Virulence Factors in Enteropathogenic and Enterohemorrhagic Escherichia coli. Infect Immun 68, no. 11 (2000): 6115–26.

    Article  PubMed  CAS  Google Scholar 

  • Elliott, S. J., L. A. Wainwright, T. K. McDaniel, K. G. Jarvis, Y. K. Deng, L. C. Lai, B. P. McNamara, M. S. Donnenberg, and J. B. Kaper. The Complete Sequence of the Locus of Enterocyte Effacement (Lee) from Enteropathogenic Escherichia coli E2348/69. Mol Microbiol 28, no. 1 (1998): 1–4.

    Article  PubMed  CAS  Google Scholar 

  • Elliott, S. J., J. Yu, and J. B. Kaper. The Cloned Locus of Enterocyte Effacement from Enterohemorrhagic Escherichia coli O157:H7 Is Unable to Confer the Attaching and Effacing Phenotype Upon E. coli K-12. Infect Immun 67, no. 8 (1999): 4260–3.

    PubMed  CAS  Google Scholar 

  • Endo, Y., K. Tsurugi, T. Yutsudo, Y. Takeda, T. Ogasawara, and K. Igarashi. Site of Action of a Vero Toxin (Vt2) from Escherichia coli O157:H7 and of Shiga Toxin on Eukaryotic Ribosomes. Rna N-Glycosidase Activity of the Toxins. Eur J Biochem 171, no. 1–2 (1988): 45–50.

    Article  PubMed  CAS  Google Scholar 

  • Freddolino, P. L., M. Y. Kalani, N. Vaidehi, W. B. Floriano, S. E. Hall, R. J. Trabanino, V. W. Kam, and W. A. Goddard, 3rd. Predicted 3d Structure for the Human Beta 2 Adrenergic Receptor and Its Binding Site for Agonists and Antagonists. Proc Natl Acad Sci U S A 101, no. 9 (2004): 2736–41.

    Article  PubMed  CAS  Google Scholar 

  • Friedberg, D., T. Umanski, Y. Fang, and I. Rosenshine. Hierarchy in the Expression of the Locus of Enterocyte Effacement Genes of Enteropathogenic Escherichia coli. Mol Microbiol 34, no. 5 (1999): 941–52.

    Article  PubMed  CAS  Google Scholar 

  • Furness, J. B. Types of Neurons in the Enteric Nervous System. J Auton Nerv Syst 81, no. 1–3 (2000): 87–96.

    Article  PubMed  CAS  Google Scholar 

  • Goosney, D. L., R. DeVinney, and B. B. Finlay. Recruitment of Cytoskeletal and Signaling Proteins to Enteropathogenic and Enterohemorrhagic Escherichia coli Pedestals. Infect Immun 69, no. 5 (2001): 3315–22.

    Article  PubMed  CAS  Google Scholar 

  • Gruenheid, S., I. Sekirov, N. A. Thomas, W. Deng, P. O’Donnell, D. Goode, Y. Li, E. A. Frey, N. F. Brown, P. Metalnikov, T. Pawson, K. Ashman, and B. B. Finlay. Identification and Characterization of Nlea, a Non-Lee-Encoded Type Iii Translocated Virulence Factor of Enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol 51, no. 5 (2004): 1233–49.

    Article  PubMed  CAS  Google Scholar 

  • Haack, K. R., C. L. Robinson, K. J. Miller, J. W. Fowlkes, and J. L. Mellies. Interaction of Ler at the Lee5 (Tir) Operon of Enteropathogenic Escherichia coli. Infection & Immunity 71, no. 1 (2003): 384–92.

    Article  CAS  Google Scholar 

  • Hughes, D. T., and V. Sperandio. Inter-Kingdom Signalling: Communication between Bacteria and Their Hosts. Nat Rev Microbiol 6, no. 2 (2008): 111–20.

    Article  PubMed  CAS  Google Scholar 

  • Ide, T., S. Laarmann, L. Greune, H. Schillers, H. Oberleithner, and M. A. Schmidt. Characterization of Translocation Pores Inserted into Plasma Membranes by Type Iii-Secreted Esp Proteins of Enteropathogenic Escherichia coli. Cell Microbiol 3, no. 10 (2001): 669–79.

    Article  PubMed  CAS  Google Scholar 

  • Iyoda, S., and H. Watanabe. Positive Effects of Multiple Pch Genes on Expression of the Locus of Enterocyte Effacement Genes and Adherence of Enterohaemorrhagic Escherichia coli O157 : H7 to Hep-2 Cells. Microbiology 150, no. Pt 7 (2004): 2357–571.

    Article  PubMed  CAS  Google Scholar 

  • Jacewicz, M., H. Clausen, E. Nudelman, A. Donohue-Rolfe, and G. T. Keusch. Pathogenesis of Shigella Diarrhea. Xi. Isolation of a Shigella Toxin-Binding Glycolipid from Rabbit Jejunum and Hela Cells and Its Identification as Globotriaosylceramide. J Exp Med 163, no. 6 (1986): 1391–404.

    Article  PubMed  CAS  Google Scholar 

  • Jarvis, K. G., J. A. Giron, A. E. Jerse, T. K. McDaniel, M. S. Donnenberg, and J. B. Kaper. Enteropathogenic Escherichia coli Contains a Putative Type Iii Secretion System Necessary for the Export of Proteins Involved in Attaching and Effacing Lesion Formation. Proc Natl Acad Sci U S A 92, no. 17 (1995): 7996–8000.

    Article  PubMed  CAS  Google Scholar 

  • Jerse, A. E., J. Yu, B. D. Tall, and J. B. Kaper. A Genetic Locus of Enteropathogenic Escherichia coli Necessary for the Production of Attaching and Effacing Lesions on Tissue Culture Cells. Proc Natl Acad Sci U S A 87, no. 20 (1990): 7839–43.

    Article  PubMed  CAS  Google Scholar 

  • Kaper, J. B., J. P. Nataro, and H. L. Mobley. Pathogenic Escherichia coli. Nat Rev Microbiol 2, no. 2 (2004): 123–40.

    Article  PubMed  CAS  Google Scholar 

  • Kenny, B., A. Abe, M. Stein, and B. B. Finlay. Enteropathogenic Escherichia coli Protein Secretion Is Induced in Response to Conditions Similar to Those in the Gastrointestinal Tract. Infect Immun 65, no. 7 (1997): 2606–12.

    PubMed  CAS  Google Scholar 

  • Kenny, B., R. DeVinney, M. Stein, D. J. Reinscheid, E. A. Frey, and B. B. Finlay. Enteropathogenic E. coli (Epec) Transfers Its Receptor for Intimate Adherence into Mammalian Cells. Cell 91, no. 4 (1997): 511–20.

    Article  PubMed  CAS  Google Scholar 

  • Kenny, B., and B. B. Finlay. Protein Secretion by Enteropathogenic Escherichia coli Is Essential for Transducing Signals to Epithelial Cells. Proc Natl Acad Sci U S A 92, no. 17 (1995): 7991–5.

    Article  PubMed  CAS  Google Scholar 

  • Kenny, B., and M. Jepson. Targeting of an Enteropathogenic Escherichia coli (Epec) Effector Protein to Host Mitochondria. Cell Microbiol 2, no. 6 (2000): 579–90.

    Article  PubMed  CAS  Google Scholar 

  • Kimmitt, P. T., C. R. Harwood, and M. R. Barer. Induction of Type 2 Shiga Toxin Synthesis in Escherichia coli O157 by 4-Quinolones. Lancet 353, no. 9164 (1999): 1588–9.

    Article  PubMed  CAS  Google Scholar 

  • Kimmitt, P. T., C. R. Harwood, and M. R. Barer. Toxin Gene Expression by Shiga Toxin-Producing Escherichia coli: The Role of Antibiotics and the Bacterial Sos Response. Emerg Infect Dis 6, no. 5 (2000): 458–65.

    Article  PubMed  CAS  Google Scholar 

  • Lindberg, A. A., J. E. Brown, N. Stromberg, M. Westling-Ryd, J. E. Schultz, and K. A. Karlsson. Identification of the Carbohydrate Receptor for Shiga Toxin Produced by Shigella dysenteriae Type 1. J Biol Chem 262, no. 4 (1987): 1779–85.

    PubMed  CAS  Google Scholar 

  • McDaniel, T. K., K. G. Jarvis, M. S. Donnenberg, and J. B. Kaper. A Genetic Locus of Enterocyte Effacement Conserved among Diverse Enterobacterial Pathogens. Proc Natl Acad Sci U S A 92, no. 5 (1995): 1664–8.

    Article  PubMed  CAS  Google Scholar 

  • McNamara, B. P., and M. S. Donnenberg. A Novel Proline-Rich Protein, Espf, Is Secreted from Enteropathogenic Escherichia coli Via the Type Iii Export Pathway. FEMS Microbiol Lett 166, no. 1 (1998): 71–8.

    Article  PubMed  CAS  Google Scholar 

  • McNamara, B. P., A. Koutsouris, C. B. O’Connell, J. P. Nougayrede, M. S. Donnenberg, and G. Hecht. Translocated Espf Protein from Enteropathogenic Escherichia coli Disrupts Host Intestinal Barrier Function. J Clin Invest 107, no. 5 (2001): 621–9.

    Article  PubMed  CAS  Google Scholar 

  • Mellies, J. L., S. J. Elliott, V. Sperandio, M. S. Donnenberg, and J. B. Kaper. The Per Regulon of Enteropathogenic Escherichia coli: Identification of a Regulatory Cascade and a Novel Transcriptional Activator, the Locus of Enterocyte Effacement (Lee)-Encoded Regulator (Ler). Mol Microbiol 33, no. 2 (1999): 296–306.

    Article  PubMed  CAS  Google Scholar 

  • Merighi, M., A. Carroll-Portillo, A. N. Septer, A. Bhatiya, and J. S. Gunn. Role of Salmonella Enterica Serovar Typhimurium Two-Component System Prea/Preb in Modulating Pmra-Regulated Gene Transcription. J Bacteriol 188, no. 1 (2006): 141–9.

    Article  PubMed  CAS  Google Scholar 

  • Merighi, M., A. N. Septer, A. Carroll-Portillo, A. Bhatiya, S. Porwollik, M. McClelland, and J. S. Gunn. Genome-Wide Analysis of the Prea/Preb (Qseb/Qsec) Regulon of Salmonella enterica Serovar Typhimurium. BMC Microbiol 9, no. 1 (2009): 42.

    Article  PubMed  Google Scholar 

  • Miller, S. T., K. B. Xavier, S. R. Campagna, M. E. Taga, M. F. Semmelhack, B. L. Bassler, and F. M. Hughson. Salmonella typhimurium Recognizes a Chemically Distinct Form of the Bacterial Quorum-Sensing Signal Ai-2. Mol Cell 15, no. 5 (2004): 677–87.

    Article  PubMed  CAS  Google Scholar 

  • Neely, M. N., and D. I. Friedman. Functional and Genetic Analysis of Regulatory Regions of Coliphage H-19b: Location of Shiga-Like Toxin and Lysis Genes Suggest a Role for Phage Functions in Toxin Release. Mol Microbiol 28, no. 6 (1998): 1255–67.

    Article  PubMed  CAS  Google Scholar 

  • Perera, L. P., L. R. Marques, and A. D. O’Brien. Isolation and Characterization of Monoclonal Antibodies to Shiga-Like Toxin Ii of Enterohemorrhagic Escherichia coli and Use of the Monoclonal Antibodies in a Colony Enzyme-Linked Immunosorbent Assay. J Clin Microbiol 26, no. 10 (1988): 2127–31.

    PubMed  CAS  Google Scholar 

  • Rasko, D. A., C. G. Moreira, R. Li de, N. C. Reading, J. M. Ritchie, M. K. Waldor, N. Williams, R. Taussig, S. Wei, M. Roth, D. T. Hughes, J. F. Huntley, M. W. Fina, J. R. Falck, and V. Sperandio. Targeting Qsec Signaling and Virulence for Antibiotic Development. Science 321, no. 5892 (2008): 1078–80.

    Article  PubMed  CAS  Google Scholar 

  • Reading, N. C., A. G. Torres, M. M. Kendall, D. T. Hughes, K. Yamamoto, and V. Sperandio. A Novel Two-Component Signaling System That Activates Transcription of an Enterohemorrhagic Escherichia coli Effector Involved in Remodeling of Host Actin. J Bacteriol 189, no. 6 (2007): 2468–76.

    Article  PubMed  CAS  Google Scholar 

  • Ritter, A., D. L. Gally, P. B. Olsen, U. Dobrindt, A. Friedrich, P. Klemm, and J. Hacker. The Pai-Associated Leux Specific Trna5(Leu) Affects Type 1 Fimbriation in Pathogenic Escherichia coli by Control of Fimb Recombinase Expression. Mol Microbiol 25, no. 5 (1997): 871–82.

    Article  PubMed  CAS  Google Scholar 

  • Roe, A. J., D. E. Hoey, and D. L. Gally. Regulation, Secretion and Activity of Type Iii-Secreted Proteins of Enterohaemorrhagic Escherichia coli O157. Biochem Soc Trans 31, no. Pt 1 (2003): 98–103.

    PubMed  CAS  Google Scholar 

  • Rosenshine, I., S. Ruschkowski, and B. B. Finlay. Expression of Attaching/Effacing Activity by Enteropathogenic Escherichia coli Depends on Growth Phase, Temperature, and Protein Synthesis Upon Contact with Epithelial Cells. Infect Immun 64, no. 3 (1996): 966–73.

    PubMed  CAS  Google Scholar 

  • Russell, R. M., F. C. Sharp, D. A. Rasko, and V. Sperandio. Qsea and Grlr/Grla Regulation of the Locus of Enterocyte Effacement Genes in Enterohemorrhagic Escherichia coli. J Bacteriol 189, no. 14 (2007): 5387–92.

    Article  PubMed  CAS  Google Scholar 

  • Schauder, S., K. Shokat, M. G. Surette, and B. L. Bassler. The Luxs Family of Bacterial Autoinducers: Biosynthesis of a Novel Quorum-Sensing Signal Molecule. Mol Microbiol 41, no. 2 (2001): 463–76.

    Article  PubMed  CAS  Google Scholar 

  • Schmitt, C. K., M. L. McKee, and A. D. O’Brien. Two Copies of Shiga-Like Toxin Ii-Related Genes Common in Enterohemorrhagic Escherichia coli Strains Are Responsible for the Antigenic Heterogeneity of the O157:H- Strain E32511. Infect Immun 59, no. 3 (1991): 1065–73.

    PubMed  CAS  Google Scholar 

  • Sharma, V. K., and R. L. Zuerner. Role of Hha and Ler in Transcriptional Regulation of the Esp Operon of Enterohemorrhagic Escherichia coli O157:H7. J Bacteriol 186, no. 21 (2004): 7290–301.

    Article  PubMed  CAS  Google Scholar 

  • Sharp, F. C., and V. Sperandio. Qsea Directly Activates Transcription of Lee1 in Enterohemorrhagic Escherichia coli. Infect Immun 75, no. 5 (2007): 2432–40.

    Article  PubMed  CAS  Google Scholar 

  • Sperandio, V., C. C. Li, and J. B. Kaper. Quorum-Sensing Escherichia coli Regulator A: A Regulator of the Lysr Family Involved in the Regulation of the Locus of Enterocyte Effacement Pathogenicity Island in Enterohemorrhagic E. coli. Infect Immun 70, no. 6 (2002): 3085–93.

    Article  PubMed  CAS  Google Scholar 

  • Sperandio, V., J. L. Mellies, W. Nguyen, S. Shin, and J. B. Kaper. Quorum Sensing Controls Expression of the Type Iii Secretion Gene Transcription and Protein Secretion in Enterohemorrhagic and Enteropathogenic Escherichia coli. Proc Natl Acad Sci U S A 96, no. 26 (1999): 15196–201.

    Article  PubMed  CAS  Google Scholar 

  • Sperandio, V., A. G. Torres, J. A. Giron, and J. B. Kaper. Quorum Sensing Is a Global Regulatory Mechanism in Enterohemorrhagic Escherichia coli O157:H7. J Bacteriol 183, no. 17 (2001): 5187–97.

    Article  PubMed  CAS  Google Scholar 

  • Sperandio, V., A. G. Torres, B. Jarvis, J. P. Nataro, and J. B. Kaper. Bacteria-Host Communication: The Language of Hormones. Proc Natl Acad Sci U S A 100, no. 15 (2003): 8951–6.

    Article  PubMed  CAS  Google Scholar 

  • Sperandio, V., A. G. Torres, and J. B. Kaper. Quorum Sensing Escherichia coli Regulators B and C (Qsebc): A Novel Two-Component Regulatory System Involved in the Regulation of Flagella and Motility by Quorum Sensing in E. coli. Mol Microbiol 43, no. 3 (2002): 809–21.

    Article  PubMed  CAS  Google Scholar 

  • Surette, M. G., and B. L. Bassler. Quorum Sensing in Escherichia coli and Salmonella typhimurium. Proc Natl Acad Sci U S A 95, no. 12 (1998): 7046–50.

    Article  PubMed  CAS  Google Scholar 

  • Surette, M. G., M. B. Miller, and B. L. Bassler. Quorum Sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A New Family of Genes Responsible for Autoinducer Production. Proc Natl Acad Sci U S A 96, no. 4 (1999): 1639–44.

    Article  PubMed  CAS  Google Scholar 

  • Tobe, T., S. A. Beatson, H. Taniguchi, H. Abe, C. M. Bailey, A. Fivian, R. Younis, S. Matthews, O. Marches, G. Frankel, T. Hayashi, and M. J. Pallen. An Extensive Repertoire of Type Iii Secretion Effectors in Escherichia coli O157 and the Role of Lambdoid Phages in Their Dissemination. Proc Natl Acad Sci U S A 103, no. 40 (2006): 14941–6.

    Article  PubMed  CAS  Google Scholar 

  • Tomson, F. L., V. K. Viswanathan, K. J. Kanack, R. P. Kanteti, K. V. Straub, M. Menet, J. B. Kaper, and G. Hecht. Enteropathogenic Escherichia coli Espg Disrupts Microtubules and in Conjunction with Orf3 Enhances Perturbation of the Tight Junction Barrier. Mol Microbiol 56, no. 2 (2005): 447–64.

    Article  PubMed  CAS  Google Scholar 

  • Tu, X., I. Nisan, C. Yona, E. Hanski, and I. Rosenshine. Esph, a New Cytoskeleton-Modulating Effector of Enterohaemorrhagic and Enteropathogenic Escherichia coli. Mol Microbiol 47, no. 3 (2003): 595–606.

    Article  PubMed  CAS  Google Scholar 

  • Waddell, T., S. Head, M. Petric, A. Cohen, and C. Lingwood. Globotriosyl Ceramide Is Specifically Recognized by the Escherichia coli Verocytotoxin 2. Biochem Biophys Res Commun 152, no. 2 (1988): 674–9.

    Article  PubMed  CAS  Google Scholar 

  • Walters, M., and V. Sperandio. Autoinducer 3 and Epinephrine Signaling in the Kinetics of Locus of Enterocyte Effacement Gene Expression in Enterohemorrhagic Escherichia coli. Infect Immun 74, no. 10 (2006): 5445–55.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, D. S., A. Brotcke, T. Henry, J. J. Margolis, K. Chan, and D. M. Monack. In Vivo Negative Selection Screen Identifies Genes Required for Francisella Virulence. Proc Natl Acad Sci U S A 104, no. 14 (2007): 6037–42.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, R. K., R. K. Shaw, S. Daniell, S. Knutton, and G. Frankel. Role of Escf, a Putative Needle Complex Protein, in the Type Iii Protein Translocation System of Enteropathogenic Escherichia coli. Cellular Microbiology 3, no. 11 (2001): 753–62.

    Article  PubMed  CAS  Google Scholar 

  • Yamashima, T. Jokichi Takamine (1854-1922), the Samurai Chemist, and His Work on Adrenalin. J Med Biogr 11, no. 2 (2003): 95–102.

    PubMed  Google Scholar 

  • Zhang, L., R. R. Chaudhuri, C. Constantinidou, J. L. Hobman, M. D. Patel, A. C. Jones, D. Sarti, A. J. Roe, I. Vlisidou, R. K. Shaw, F. Falciani, M. P. Stevens, D. L. Gally, S. Knutton, G. Frankel, C. W. Penn, and M. J. Pallen. “Regulators Encoded in the Escherichia coli Type Iii Secretion System 2 Gene Cluster Influence Expression of Genes within the Locus for Enterocyte Effacement in Enterohemorrhagic E. coli O157:H7.” Infect Immun 72, no. 12 (2004): 7282-93.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, W., M. Bielaszewska, T. Kuczius, and H. Karch. Identification, Characterization, and Distribution of a Shiga Toxin 1 Gene Variant (Stx(1c)) in Escherichia coli Strains Isolated from Humans. J Clin Microbiol 40, no. 4 (2002): 1441-6.

    Article  PubMed  CAS  Google Scholar 

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  1. Molecular Microbiology Department, University of Texas Southwestern Medical Center, 6000 Harry Hines Bvld, Dallas, 75390, TX, USA

    Cristiano G. Moreira & Vanessa Sperandio

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  1. Cristiano G. Moreira
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  2. Vanessa Sperandio
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Correspondence to Cristiano G. Moreira .

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  1. Health Sciences Center, School of Pharmacy, Texas Tech University, 4th Street 3601, Lubbock, 79430, USA

    Mark Lyte

  2. School of Medicine, Dept. Infection, Immunity & Inflammation, University of Leicester, Leicester, United Kingdom

    Primrose P.E. Freestone

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Moreira, C.G., Sperandio, V. (2010). The Epinephrine/Norepinephrine/Autoinducer-3 Interkingdom Signaling System in Escherichia coli O157:H7. In: Lyte, M., Freestone, P. (eds) Microbial Endocrinology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5576-0_12

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