Abstract
Energy is defined as the ability of a system to perform work. Energy is present in many forms, such as luminous energy coming from sun or kinetic energy obtained from wind and water. Humans obtain their energy from foods which is stored in the CH bonds of carbohydrates, lipids, proteins, and alcohol. To obtain the energy to live, grow, and reproduce, organisms must extract it in a usable form from plants and/or animal foods. This potential chemical energy is liberated inside cells through oxidative pathways that convert these CH bonds to energy-rich molecules such as creatine phosphate and adenosine triphosphate (ATP).
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Spiller, R.C. (1994). Intestinal absorptive function. Gut, 35(1 Suppl), S5–S9.
Saraste, M. (1999). Oxidative phosphorylation at the fin de siecle. Science, 283(5407), 1488–1493.
Elia, M., & Cummings, J.H. (2007). Physiological aspects of energy metabolism and gastrointestinal effects of carbohydrates. European Journal of Clinical Nutrition, 61(Suppl 1), S40–S74.
Livesey, G., & Elia, M. (1988). Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: Evaluation of errors with special reference to the detailed composition of fuels. American Journal of Clinical Nutrition, 47(4), 608–628.
Rolfe, D.F., & Brown, G.C. (1997). Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiology Review, 77(3), 731–758.
Ravussin, E., Lillioja, S., Anderson, T.E., Christin, L., Bogardus, C. (1986). Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. Journal of Clinical Investigation, 78(6), 1568–1578.
Roza, A.M., & Shizgal, H.M. (1984). The Harris Benedict equation reevaluated: Resting energy requirements and the body cell mass. American Journal of Clinical Nutrition, 40, 168–182.
Schofield, W.N. (1985). Predicting basal metabolic rate, new standards and review of previous work. Human Nutrition – Clinical Nutrition, 39(Suppl 1), 5–41.
Cunningham, J.J. (1991). Body composition as a determinant of energy expenditure: A synthetic review and a proposed general prediction equation. American Journal of Clinical Nutrition, 54(6), 963–969.
Human energy requirements: Report of a joint FAO/ WHO/UNU Expert Consultation. (2005). Food Nutrition Bulletin, 26(1), 166.
Henry, C.J. (2005). Basal metabolic rate studies in humans: Measurement and development of new equations. Public Health Nutrition, 8(7A), 1133–1152.
Ramirez-Zea, M. (2005). Validation of three predictive equations for basal metabolic rate in adults. Public Health Nutrition, 8(7A), 1213–1228.
Johnstone, A.M., Murison, S.D., Duncan, J.S., Rance, K.A., Speakman, J.R. (2005). Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. American Journal of Clinical Nutrition, 82(5), 941–948.
Keys, A., Taylor, H.L., Grande, F. (1973). Basal metabolism and age of adult man. Metabolism, 22(4), 579–587.
Frisard, M.I., Fabre, J.M., Russell, R.D., et al. (2007). Physical activity level and physical functionality in nonagenarians compared to individuals aged 60–74 years. Journal of Gerontology A: Biological Science Medicine Science, 62(7), 783–788.
Bosy-Westphal, A., Eichhorn, C., Kutzner, D., Illner, K., Heller, M., Muller, M.J. (2003). The age-related decline in resting energy expenditure in humans is due to the loss of fat-free mass and to alterations in its metabolically active components. Journal of Nutrition, 133(7), 2356–2362.
Heymsfield, S.B., Gallagher, D., Kotler, D.P., Wang, Z., Allison, D.B., Heshka, S. (2002). Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass. American Journal of Physiology: Endocrinology Metabolism, 282(1), E132–E138.
Bosy-Westphal, A., Reinecke, U., Schlorke, T., et al. (2004). Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults. International Journal of Obesity Related Metabolic Disorder, 28(1), 72–79.
Saad, M.F., Alger, S.A., Zurlo, F., Young, J.B., Bogardus, C., Ravussin, E. (1991). Ethnic differences in sympathetic nervous system-mediated energy expenditure. American Journal of Physiology, 261(6 Pt 1), E789–E794.
Schwartz, R.S., Jaeger, L.F., Veith, R.C. (1988). Effect of clonidine on the thermic effect of feeding in humans. American Journal of Physiology, 254(1 Pt 2), R90–R94.
Spraul, M., Ravussin, E., Fontvieille, A.M., Rising, R., Larson, D.E., Anderson, E.A. (1993). Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. Journal of Clinical Investigation, 92(4), 1730–1735.
Rising, R., Keys, A., Ravussin, E., Bogardus, C. (1992). Concomitant interindividual variation in body temperature and metabolic rate. American Journal of Physiology, 263(4 Pt 1), E730–E734.
Bogardus, C., Lillioja, S., Ravussin, E., et al. (1986). Familial dependence of the resting metabolic rate. New England Journal of Medicine, 315(2), 96–100.
Bouchard, C., Tremblay, A., Nadeau, A., et al. (1989). Genetic effect in resting and exercise metabolic rates. Metabolism, 38(4), 364–370.
Weststrate, J.A. (1993). Resting metabolic rate and diet-induced thermogenesis: A methodological reappraisal. American Journal of Clinical Nutrition, 58(5), 592–601.
Tataranni, P.A., Larson, D.E., Snitker, S., Ravussin, E. (1995). Thermic effect of food in humans: Methods and results from use of a respiratory chamber. American Journal of Clinical Nutrition, 61(5), 1013–1019.
Brundin, T., Thorne, A., Wahren, J. (1992). Heat leakage across the abdominal wall and meal-induced thermogenesis in normal-weight and obese subjects. Metabolism, 41(1), 49–55.
Speakman, J.R. (1998). The history and theory of the doubly labeled water technique. American Journal of Clinical Nutrition, 68(4), 932S–938S.
Schulz, L.O., & Schoeller, D.A. (1994). A compilation of total daily energy expenditures and body weights in healthy adults. American Journal of Clinical Nutrition, 60(5), 676–681.
Black, A.E., Coward, W.A., Cole, T.J., Prentice, A.M. (1996). Human energy expenditure in affluent societies: An analysis of 574 doubly-labelled water measurements. European Journal of Clinical Nutrition, 50(2), 72–92.
Jequier, E., Acheson, K., Schutz, Y. (1987). Assessment of energy expenditure and fuel utilization in man. Annual Review of Nutrition, 7, 187–208.
Schoeller, D.A. (1999). Recent advances from application of doubly labeled water to measurement of human energy expenditure. Journal of Nutrition, 129(10), 1765–1768.
Ravussin, E., Harper, I.T., Rising, R., Bogardus, C. (1991). Energy expenditure by doubly labeled water: Validation in lean and obese subjects. American Journal of Physiology, 261(3 Pt 1), E402–E409.
Redman, L.M., Heilbronn, L.K., Martin, C.K., et al. (2009). Metabolic and behavioral compensations in response to caloric restriction: Implications for the maintenance of weight loss. PLoS ONE, 4(2), e4377.
Rosenbaum, M., Goldsmith, R., Bloomfield, D., et al. (2005). Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. Journal of Clinical Investigation, 115(12), 3579–3586.
Stock, M.J. (1999). Gluttony and thermogenesis revisited. International Journal of Obesity Related Metabolic Disorder, 23(11), 1105–1117.
Flatt, J.P., Ravussin, E., Acheson, K.J., Jequier, E. (1985). Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances. Journal of Clinical Investigation, 76(3), 1019–1024.
Smith, S.R., de Jonge, L., Zachwieja, J.J., et al. (2000). Fat and carbohydrate balances during adaptation to a high-fat. American Journal of Clinical Nutrition, 71(2), 450–457.
Davy, K.P., Horton, T., Davy, B.M., Bessessen, D., Hill, J.O. (2001). Regulation of macronutrient balance in healthy young and older men. International Journal of Obesity Related Metabolic Disorder, 25(10), 1497–1502.
Hill, J.O., Peters, J.C., Reed, G.W., Schlundt, D.G., Sharp, T., Greene, H.L. (1991). Nutrient balance in humans: Effects of diet composition. American Journal of Clinical Nutrition, 54(1), 10–17.
Schrauwen, P., van Marken Lichtenbelt, W.D., Saris, W.H., Westerterp, K.R. (1997). The adaptation of nutrient oxidation to nutrient intake on a high-fat diet. Zeitschrift Fur Ernahrungswissenschaft, 36(4), 306–309.
Shetty, P.S., Prentice, A.M., Goldberg, G.R., et al. (1994). Alterations in fuel selection and voluntary food intake in response to isoenergetic manipulation of glycogen stores in humans. American Journal of Clinical Nutrition, 60(4), 534–543.
Abbott, W.G., Howard, B.V., Christin, L., et al. (1988). Short-term energy balance: Relationship with protein, carbohydrate, and fat balances. American Journal of Physiology, 255(3 Pt 1), E332–E337.
Chascione, C., Elwyn, D.H., Davila, M., Gil, K.M., Askanazi, J., Kinney, J.M. (1987). Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue. American Journal of Physiology, 253(6 Pt 1), E664–E669.
Acheson, K.J., Schutz, Y., Bessard, T., Anantharaman, K., Flatt, J.P., Jequier, E. (1988). Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. American Journal of Clinical Nutrition, 48(2), 240–247.
Aarsland, A., Chinkes, D., Wolfe, R.R. (1997). Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding. American Journal of Clinical Nutrition, 65(6), 1774–1782.
Hellerstein, M.K. (1999). De novo lipogenesis in humans: Metabolic and regulatory aspects. European Journal of Clinical Nutrition, 53(Suppl 1), S53–S65.
Bray, G.A. (1991). Treatment for obesity: A nutrient balance/nutrient partition approach. Nutrition Reviews, 49(2), 33–45.
Schutz, Y., Flatt, J.P, Jequier, E. (1989). Failure of dietary fat intake to promote fat oxidation: A factor favoring the development of obesity. American Journal of Clinical Nutrition, 50(2), 307–314.
Frayn, K.N. (2002). Adipose tissue as a buffer for daily lipid flux. Diabetologia, 45(9), 1201–1210.
Zurlo, F., Lillioja, S., Esposito-Del Puente, A., et al. (1990). Low ratio of fat to carbohydrate oxidation as predictor of weight gain: Study of 24-h RQ. American Journal of Physiology, 259(5 Pt 1), E650–E657.
Schrauwen, P., & Westerterp, K.R. (2000). The role of high-fat diets and physical activity in the regulation of body weight. British Journal of Nutrition, 84(4), 417–427.
Ravussin, E., & Swinburn, B.A. (1993). Metabolic predictors of obesity: Cross-sectional versus longitudinal data. International Journal of Obesity Related Metabolic Disorder, 17(Suppl 3), S28–S31; discussion S41–S22.
Knowler, W.C., Pettitt, D.J., Saad, M.F., et al. (1991). Obesity in the Pima Indians: Its magnitude and relationship with diabetes. American Journal of Clinical Nutrition, 53(6 Suppl), 1543S–1551S.
Weyer, C., Snitker, S., Bogardus, C., Ravussin, E. (1999). Energy metabolism in African Americans: Potential risk factors for obesity. American Journal of Clinical Nutrition, 70(1), 13–20.
Melby, C.L., Ho, R.C., Jeckel, K., Beal, L., Goran, M., Donahoo, W.T. (2000). Comparison of risk factors for obesity in young, nonobese African-American and Caucasian women. International Journal of Obesity Related Metabolic Disorder, 24(11), 1514–1522.
Ravussin, E., Lillioja, S., Knowler, W.C., et al. (1988). Reduced rate of energy expenditure as a risk factor for body-weight gain. New England Journal of Medicine, 318(8), 467–472.
Astrup, A., Gotzsche, P.C., van de Werken, K., et al. (1999). Meta-analysis of resting metabolic rate in formerly obese subjects. American Journal of Clinical Nutrition, 69(6), 1117–1122.
Amatruda, J.M., Statt, M.C., Welle, S.L. (1993). Total and resting energy expenditure in obese women reduced to ideal body weight. Journal of Clinical Investigation, 92(3), 1236–1242.
Weinsier, R.L., Nelson, K.M., Hensrud, D.D., Darnell, B.E., Hunter, G.R., Schutz, Y. (1995). Metabolic predictors of obesity. Contribution of resting energy expenditure, thermic effect of food, and fuel utilization to four-year weight gain of post-obese and never-obese women. Journal of Clinical Investigation, 95(3), 980–985.
Prentice, A.M., & Jebb, S.A. (1995). Obesity in Britain: Gluttony or sloth? British Medical Journal, 311(7002), 437–439.
Westerterp, K.R., & Speakman, J.R. (2008). Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals. International Journal of Obesity (London), 32(8), 1256–1263.
Swinburn, B.A., Jolley, D., Kremer, P.J., Salbe, A.D., Ravussin, E. (2006). Estimating the effects of energy imbalance on changes in body weight in children. American Journal of Clinical Nutrition, 83(4), 859–863.
Swinburn, B.A., Sacks, G., Lo, S.K., et al. (2009). Estimating the changes in energy flux that characterize the rise in obesity prevalence. American Journal of Clinical Nutrition, 89(6), 1723–1728.
Schoeller, D.A., Shay, K., Kushner, R.F. (1997). How much physical activity is needed to minimize weight gain in previously obese women? American Journal of Clinical Nutrition, 66(3), 551–556.
Zurlo, F., Ferraro, R.T., Fontvielle, A.M., Rising, R., Bogardus, C., Ravussin, E. (1992). Spontaneous physical activity and obesity: Cross-sectional and longitudinal studies in Pima Indians. American Journal of Physiology, 263(2 Pt 1), E296–E300.
Levine, J.A., Eberhardt, N.L., Jensen, M.D. (1999). Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283(5399), 212–214.
Johannsen, D.L., & Ravussin, E. (2008). Spontaneous physical activity: Relationship between fidgeting and body weight control. Current Opinion in Endocrinology, Diabetes, Obesity, 15(5), 409–415[AU1].
Toubro, S., Sorensen, T.I., Hindsberger, C., Christensen, N.J., Astrup, A. (1998). Twenty-four-hour respiratory quotient: The role of diet and familial resemblance. Journal of Clinical Endocrinology and Metabolism, 83(8), 2758–2764.
Astrup, A., Buemann, B., Christensen, N.J., Toubro, S. (1994). Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women. American Journal of Physiology, 266(4 Pt 1), E592–E599.
Larson, D.E., Ferraro, R.T., Robertson, D.S., Ravussin, E. (1995). Energy metabolism in weight-stable postobese individuals. American Journal of Clinical Nutrition, 62(4), 735–739.
Froidevaux, F., Schutz, Y., Christin, L., Jequier, E. (1993). Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period. American Journal of Clinical Nutrition, 57(1), 35–42.
Flatt, J.P. (1987). Dietary fat, carbohydrate balance, and weight maintenance: Effects of exercise. American Journal of Clinical Nutrition, 45(1 Suppl), 296–306.
Pannacciulli, N., Salbe, A.D., Ortega, E., Venti, C.A., Bogardus, C., Krakoff, J. (2007). The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake. American Journal of Clinical Nutrition, 86(3), 625–632.
Eckel, R.H., Hernandez, T.L., Bell, M.L., et al. (2006). Carbohydrate balance predicts weight and fat gain in adults. American Journal of Clinical Nutrition, 83(4), 803–808.
Sims, E.A., Danforth, E., Jr., Horton, E.S., Bray, G.A., Glennon, J.A., Salans, L.B. (1973). Endocrine and metabolic effects of experimental obesity in man. Recent Progress in Hormone Research, 29, 457–496.
Bouchard, C., Tremblay, A., Despres, J.P., et al. (1990). The response to long-term overfeeding in identical twins. New England Journal of Medicine, 322(21), 1477–1482.
Harper, M.E., Green, K., Brand, M.D. (2008). The efficiency of cellular energy transduction and its implications for obesity. Annual Review of Nutrition, 28, 13–33.
Lowell, B.B., & Spiegelman, B.M. (2000). Towards a molecular understanding of adaptive thermogenesis. Nature, 404(6778), 652–660.
Rosenbaum, M., Vandenborne, K., Goldsmith, R., et al. (2003). Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 285(1), R183–R192.
Weyer, C., Pratley, R.E., Salbe, A.D., Bogardus, C., Ravussin, E., Tataranni, P.A. (2000). Energy expenditure, fat oxidation, and body weight regulation: A study of metabolic adaptation to long-term weight change. Journal of Clinical Endocrinology and Metabolism, 85(3), 1087–1094.
de Jonge, L., & Bray, G.A. (1997). The thermic effect of food and obesity: A critical review. Obesity Research, 5(6), 622–631.
Christin, L., O’Connell, M., Bogardus, C., Danforth, E., Jr., Ravussin, E. (1993). Norepinephrine turnover and energy expenditure in Pima Indian and white men. Metabolism, 42(6), 723–729.
Snitker, S., Tataranni, P.A., Ravussin, E. (1998). Respiratory quotient is inversely associated with muscle sympathetic nerve activity. Journal of Clinical Endocrinology and Metabolism, 83(11), 3977–3979.
Astrup, A., Buemann, B., Gluud, C., Bennett, P., Tjur, T., Christensen, N. (1995). Prognostic markers for diet-induced weight loss in obese women. International Journal of Obesity Related Metabolic Disorder, 19(4), 275–278.
Tataranni, P.A., Young, J.B., Bogardus, C., Ravussin, E. (1997). A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men. Obesity Research, 5(4), 341–347.
Loos, R.J., & Bouchard, C. (2008). FTO: The first gene contributing to common forms of human obesity. Obesity Review, 9(3), 246–250.
Loos, R.J., Lindgren, C.M., Li, S., et al. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics, 40(6), 768–775.
Cripps, R.L., Archer, Z.A., Mercer, J.G., Ozanne, S.E. (2007). Early life programming of energy balance. Biochemical Society Transactions, 35(Pt 5), 1203–1204.
Uauy, R., Kain, J., Mericq, V., Rojas, J., Corvalan, C. (2008). Nutrition, child growth, and chronic disease prevention. Annals of Medicine, 40(1), 11–20.
Seale, P., & Lazar, M.A. (2009). Brown fat in humans: Turning up the heat on obesity. Diabetes, 58(7), 1482–1484.
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Galgani, J., Ravussin, E. (2011). Principles of Human Energy Metabolism. In: Ahima, R. (eds) Metabolic Basis of Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1607-5_1
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