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Principles of Human Energy Metabolism

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Abstract

Energy is defined as the ability of a system to perform work. Energy is present in many forms, such as luminous energy coming from sun or kinetic energy obtained from wind and water. Humans obtain their energy from foods which is stored in the CH bonds of carbohydrates, lipids, proteins, and alcohol. To obtain the energy to live, grow, and reproduce, organisms must extract it in a usable form from plants and/or animal foods. This potential chemical energy is liberated inside cells through oxidative pathways that convert these CH bonds to energy-rich molecules such as creatine phosphate and adenosine triphosphate (ATP).

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References

  1. Spiller, R.C. (1994). Intestinal absorptive function. Gut, 35(1 Suppl), S5–S9.

    Article  PubMed  CAS  Google Scholar 

  2. Saraste, M. (1999). Oxidative phosphorylation at the fin de siecle. Science, 283(5407), 1488–1493.

    Article  PubMed  CAS  Google Scholar 

  3. Elia, M., & Cummings, J.H. (2007). Physiological aspects of energy metabolism and gastrointestinal effects of carbohydrates. European Journal of Clinical Nutrition, 61(Suppl 1), S40–S74.

    Article  PubMed  CAS  Google Scholar 

  4. Livesey, G., & Elia, M. (1988). Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: Evaluation of errors with special reference to the detailed composition of fuels. American Journal of Clinical Nutrition, 47(4), 608–628.

    PubMed  CAS  Google Scholar 

  5. Rolfe, D.F., & Brown, G.C. (1997). Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiology Review, 77(3), 731–758.

    CAS  Google Scholar 

  6. Ravussin, E., Lillioja, S., Anderson, T.E., Christin, L., Bogardus, C. (1986). Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. Journal of Clinical Investigation, 78(6), 1568–1578.

    Article  PubMed  CAS  Google Scholar 

  7. Roza, A.M., & Shizgal, H.M. (1984). The Harris Benedict equation reevaluated: Resting energy requirements and the body cell mass. American Journal of Clinical Nutrition, 40, 168–182.

    PubMed  CAS  Google Scholar 

  8. Schofield, W.N. (1985). Predicting basal metabolic rate, new standards and review of previous work. Human Nutrition – Clinical Nutrition, 39(Suppl 1), 5–41.

    PubMed  Google Scholar 

  9. Cunningham, J.J. (1991). Body composition as a determinant of energy expenditure: A synthetic review and a proposed general prediction equation. American Journal of Clinical Nutrition, 54(6), 963–969.

    PubMed  CAS  Google Scholar 

  10. Human energy requirements: Report of a joint FAO/ WHO/UNU Expert Consultation. (2005). Food Nutrition Bulletin, 26(1), 166.

    Google Scholar 

  11. Henry, C.J. (2005). Basal metabolic rate studies in humans: Measurement and development of new equations. Public Health Nutrition, 8(7A), 1133–1152.

    Article  PubMed  CAS  Google Scholar 

  12. Ramirez-Zea, M. (2005). Validation of three predictive equations for basal metabolic rate in adults. Public Health Nutrition, 8(7A), 1213–1228.

    Article  PubMed  Google Scholar 

  13. Johnstone, A.M., Murison, S.D., Duncan, J.S., Rance, K.A., Speakman, J.R. (2005). Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. American Journal of Clinical Nutrition, 82(5), 941–948.

    PubMed  CAS  Google Scholar 

  14. Keys, A., Taylor, H.L., Grande, F. (1973). Basal metabolism and age of adult man. Metabolism, 22(4), 579–587.

    Article  PubMed  CAS  Google Scholar 

  15. Frisard, M.I., Fabre, J.M., Russell, R.D., et al. (2007). Physical activity level and physical functionality in nonagenarians compared to individuals aged 60–74 years. Journal of Gerontology A: Biological Science Medicine Science, 62(7), 783–788.

    Google Scholar 

  16. Bosy-Westphal, A., Eichhorn, C., Kutzner, D., Illner, K., Heller, M., Muller, M.J. (2003). The age-related decline in resting energy expenditure in humans is due to the loss of fat-free mass and to alterations in its metabolically active components. Journal of Nutrition, 133(7), 2356–2362.

    PubMed  CAS  Google Scholar 

  17. Heymsfield, S.B., Gallagher, D., Kotler, D.P., Wang, Z., Allison, D.B., Heshka, S. (2002). Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass. American Journal of Physiology: Endocrinology Metabolism, 282(1), E132–E138.

    CAS  Google Scholar 

  18. Bosy-Westphal, A., Reinecke, U., Schlorke, T., et al. (2004). Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults. International Journal of Obesity Related Metabolic Disorder, 28(1), 72–79.

    Article  CAS  Google Scholar 

  19. Saad, M.F., Alger, S.A., Zurlo, F., Young, J.B., Bogardus, C., Ravussin, E. (1991). Ethnic differences in sympathetic nervous system-mediated energy expenditure. American Journal of Physiology, 261(6 Pt 1), E789–E794.

    PubMed  CAS  Google Scholar 

  20. Schwartz, R.S., Jaeger, L.F., Veith, R.C. (1988). Effect of clonidine on the thermic effect of feeding in humans. American Journal of Physiology, 254(1 Pt 2), R90–R94.

    PubMed  CAS  Google Scholar 

  21. Spraul, M., Ravussin, E., Fontvieille, A.M., Rising, R., Larson, D.E., Anderson, E.A. (1993). Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. Journal of Clinical Investigation, 92(4), 1730–1735.

    Article  PubMed  CAS  Google Scholar 

  22. Rising, R., Keys, A., Ravussin, E., Bogardus, C. (1992). Concomitant interindividual variation in body temperature and metabolic rate. American Journal of Physiology, 263(4 Pt 1), E730–E734.

    PubMed  CAS  Google Scholar 

  23. Bogardus, C., Lillioja, S., Ravussin, E., et al. (1986). Familial dependence of the resting metabolic rate. New England Journal of Medicine, 315(2), 96–100.

    Article  PubMed  CAS  Google Scholar 

  24. Bouchard, C., Tremblay, A., Nadeau, A., et al. (1989). Genetic effect in resting and exercise metabolic rates. Metabolism, 38(4), 364–370.

    Article  PubMed  CAS  Google Scholar 

  25. Weststrate, J.A. (1993). Resting metabolic rate and diet-induced thermogenesis: A methodological reappraisal. American Journal of Clinical Nutrition, 58(5), 592–601.

    PubMed  CAS  Google Scholar 

  26. Tataranni, P.A., Larson, D.E., Snitker, S., Ravussin, E. (1995). Thermic effect of food in humans: Methods and results from use of a respiratory chamber. American Journal of Clinical Nutrition, 61(5), 1013–1019.

    PubMed  CAS  Google Scholar 

  27. Brundin, T., Thorne, A., Wahren, J. (1992). Heat leakage across the abdominal wall and meal-induced thermogenesis in normal-weight and obese subjects. Metabolism, 41(1), 49–55.

    Article  PubMed  CAS  Google Scholar 

  28. Speakman, J.R. (1998). The history and theory of the doubly labeled water technique. American Journal of Clinical Nutrition, 68(4), 932S–938S.

    PubMed  CAS  Google Scholar 

  29. Schulz, L.O., & Schoeller, D.A. (1994). A compilation of total daily energy expenditures and body weights in healthy adults. American Journal of Clinical Nutrition, 60(5), 676–681.

    PubMed  CAS  Google Scholar 

  30. Black, A.E., Coward, W.A., Cole, T.J., Prentice, A.M. (1996). Human energy expenditure in affluent societies: An analysis of 574 doubly-labelled water measurements. European Journal of Clinical Nutrition, 50(2), 72–92.

    PubMed  CAS  Google Scholar 

  31. Jequier, E., Acheson, K., Schutz, Y. (1987). Assessment of energy expenditure and fuel utilization in man. Annual Review of Nutrition, 7, 187–208.

    Article  PubMed  CAS  Google Scholar 

  32. Schoeller, D.A. (1999). Recent advances from application of doubly labeled water to measurement of human energy expenditure. Journal of Nutrition, 129(10), 1765–1768.

    PubMed  CAS  Google Scholar 

  33. Ravussin, E., Harper, I.T., Rising, R., Bogardus, C. (1991). Energy expenditure by doubly labeled water: Validation in lean and obese subjects. American Journal of Physiology, 261(3 Pt 1), E402–E409.

    PubMed  CAS  Google Scholar 

  34. Redman, L.M., Heilbronn, L.K., Martin, C.K., et al. (2009). Metabolic and behavioral compensations in response to caloric restriction: Implications for the maintenance of weight loss. PLoS ONE, 4(2), e4377.

    Article  PubMed  CAS  Google Scholar 

  35. Rosenbaum, M., Goldsmith, R., Bloomfield, D., et al. (2005). Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. Journal of Clinical Investigation, 115(12), 3579–3586.

    Article  PubMed  CAS  Google Scholar 

  36. Stock, M.J. (1999). Gluttony and thermogenesis revisited. International Journal of Obesity Related Metabolic Disorder, 23(11), 1105–1117.

    Article  CAS  Google Scholar 

  37. Flatt, J.P., Ravussin, E., Acheson, K.J., Jequier, E. (1985). Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances. Journal of Clinical Investigation, 76(3), 1019–1024.

    Article  PubMed  CAS  Google Scholar 

  38. Smith, S.R., de Jonge, L., Zachwieja, J.J., et al. (2000). Fat and carbohydrate balances during adaptation to a high-fat. American Journal of Clinical Nutrition, 71(2), 450–457.

    PubMed  CAS  Google Scholar 

  39. Davy, K.P., Horton, T., Davy, B.M., Bessessen, D., Hill, J.O. (2001). Regulation of macronutrient balance in healthy young and older men. International Journal of Obesity Related Metabolic Disorder, 25(10), 1497–1502.

    Article  CAS  Google Scholar 

  40. Hill, J.O., Peters, J.C., Reed, G.W., Schlundt, D.G., Sharp, T., Greene, H.L. (1991). Nutrient ­balance in humans: Effects of diet composition. American Journal of Clinical Nutrition, 54(1), 10–17.

    PubMed  CAS  Google Scholar 

  41. Schrauwen, P., van Marken Lichtenbelt, W.D., Saris, W.H., Westerterp, K.R. (1997). The adaptation of nutrient oxidation to nutrient intake on a high-fat diet. Zeitschrift Fur Ernahrungswissenschaft, 36(4), 306–309.

    Article  PubMed  CAS  Google Scholar 

  42. Shetty, P.S., Prentice, A.M., Goldberg, G.R., et al. (1994). Alterations in fuel selection and voluntary food intake in response to isoenergetic manipulation of glycogen stores in humans. American Journal of Clinical Nutrition, 60(4), 534–543.

    PubMed  CAS  Google Scholar 

  43. Abbott, W.G., Howard, B.V., Christin, L., et al. (1988). Short-term energy balance: Relationship with protein, carbohydrate, and fat balances. American Journal of Physiology, 255(3 Pt 1), E332–E337.

    PubMed  CAS  Google Scholar 

  44. Chascione, C., Elwyn, D.H., Davila, M., Gil, K.M., Askanazi, J., Kinney, J.M. (1987). Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue. American Journal of Physiology, 253(6 Pt 1), E664–E669.

    PubMed  CAS  Google Scholar 

  45. Acheson, K.J., Schutz, Y., Bessard, T., Anantharaman, K., Flatt, J.P., Jequier, E. (1988). Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. American Journal of Clinical Nutrition, 48(2), 240–247.

    PubMed  CAS  Google Scholar 

  46. Aarsland, A., Chinkes, D., Wolfe, R.R. (1997). Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding. American Journal of Clinical Nutrition, 65(6), 1774–1782.

    PubMed  CAS  Google Scholar 

  47. Hellerstein, M.K. (1999). De novo lipogenesis in humans: Metabolic and regulatory aspects. European Journal of Clinical Nutrition, 53(Suppl 1), S53–S65.

    Article  PubMed  Google Scholar 

  48. Bray, G.A. (1991). Treatment for obesity: A nutrient balance/nutrient partition approach. Nutrition Reviews, 49(2), 33–45.

    Article  PubMed  CAS  Google Scholar 

  49. Schutz, Y., Flatt, J.P, Jequier, E. (1989). Failure of dietary fat intake to promote fat oxidation: A factor favoring the development of obesity. American Journal of Clinical Nutrition, 50(2), 307–314.

    PubMed  CAS  Google Scholar 

  50. Frayn, K.N. (2002). Adipose tissue as a buffer for daily lipid flux. Diabetologia, 45(9), 1201–1210.

    Article  PubMed  CAS  Google Scholar 

  51. Zurlo, F., Lillioja, S., Esposito-Del Puente, A., et al. (1990). Low ratio of fat to carbohydrate oxidation as predictor of weight gain: Study of 24-h RQ. American Journal of Physiology, 259(5 Pt 1), E650–E657.

    PubMed  CAS  Google Scholar 

  52. Schrauwen, P., & Westerterp, K.R. (2000). The role of high-fat diets and physical activity in the regulation of body weight. British Journal of Nutrition, 84(4), 417–427.

    Article  PubMed  CAS  Google Scholar 

  53. Ravussin, E., & Swinburn, B.A. (1993). Metabolic predictors of obesity: Cross-sectional versus longitudinal data. International Journal of Obesity Related Metabolic Disorder, 17(Suppl 3), S28–S31; discussion S41–S22.

    Google Scholar 

  54. Knowler, W.C., Pettitt, D.J., Saad, M.F., et al. (1991). Obesity in the Pima Indians: Its magnitude and relationship with diabetes. American Journal of Clinical Nutrition, 53(6 Suppl), 1543S–1551S.

    PubMed  CAS  Google Scholar 

  55. Weyer, C., Snitker, S., Bogardus, C., Ravussin, E. (1999). Energy metabolism in African Americans: Potential risk factors for obesity. American Journal of Clinical Nutrition, 70(1), 13–20.

    PubMed  CAS  Google Scholar 

  56. Melby, C.L., Ho, R.C., Jeckel, K., Beal, L., Goran, M., Donahoo, W.T. (2000). Comparison of risk factors for obesity in young, nonobese African-American and Caucasian women. International Journal of Obesity Related Metabolic Disorder, 24(11), 1514–1522.

    Article  CAS  Google Scholar 

  57. Ravussin, E., Lillioja, S., Knowler, W.C., et al. (1988). Reduced rate of energy expenditure as a risk factor for body-weight gain. New England Journal of Medicine, 318(8), 467–472.

    Article  PubMed  CAS  Google Scholar 

  58. Astrup, A., Gotzsche, P.C., van de Werken, K., et al. (1999). Meta-analysis of resting metabolic rate in formerly obese subjects. American Journal of Clinical Nutrition, 69(6), 1117–1122.

    PubMed  CAS  Google Scholar 

  59. Amatruda, J.M., Statt, M.C., Welle, S.L. (1993). Total and resting energy expenditure in obese women reduced to ideal body weight. Journal of Clinical Investigation, 92(3), 1236–1242.

    Article  PubMed  CAS  Google Scholar 

  60. Weinsier, R.L., Nelson, K.M., Hensrud, D.D., Darnell, B.E., Hunter, G.R., Schutz, Y. (1995). Metabolic predictors of obesity. Contribution of resting energy expenditure, thermic effect of food, and fuel utilization to four-year weight gain of post-obese and never-obese women. Journal of Clinical Investigation, 95(3), 980–985.

    Article  PubMed  CAS  Google Scholar 

  61. Prentice, A.M., & Jebb, S.A. (1995). Obesity in Britain: Gluttony or sloth? British Medical Journal, 311(7002), 437–439.

    PubMed  CAS  Google Scholar 

  62. Westerterp, K.R., & Speakman, J.R. (2008). Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals. International Journal of Obesity (London), 32(8), 1256–1263.

    Article  CAS  Google Scholar 

  63. Swinburn, B.A., Jolley, D., Kremer, P.J., Salbe, A.D., Ravussin, E. (2006). Estimating the effects of energy imbalance on changes in body weight in children. American Journal of Clinical Nutrition, 83(4), 859–863.

    PubMed  CAS  Google Scholar 

  64. Swinburn, B.A., Sacks, G., Lo, S.K., et al. (2009). Estimating the changes in energy flux that characterize the rise in obesity prevalence. American Journal of Clinical Nutrition, 89(6), 1723–1728.

    Article  PubMed  CAS  Google Scholar 

  65. Schoeller, D.A., Shay, K., Kushner, R.F. (1997). How much physical activity is needed to minimize weight gain in previously obese women? American Journal of Clinical Nutrition, 66(3), 551–556.

    PubMed  CAS  Google Scholar 

  66. Zurlo, F., Ferraro, R.T., Fontvielle, A.M., Rising, R., Bogardus, C., Ravussin, E. (1992). Spontaneous physical activity and obesity: Cross-sectional and longitudinal studies in Pima Indians. American Journal of Physiology, 263(2 Pt 1), E296–E300.

    PubMed  CAS  Google Scholar 

  67. Levine, J.A., Eberhardt, N.L., Jensen, M.D. (1999). Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283(5399), 212–214.

    Article  PubMed  CAS  Google Scholar 

  68. Johannsen, D.L., & Ravussin, E. (2008). Spontaneous physical activity: Relationship between fidgeting and body weight control. Current Opinion in Endocrinology, Diabetes, Obesity, 15(5), 409–415[AU1].

    Article  Google Scholar 

  69. Toubro, S., Sorensen, T.I., Hindsberger, C., Christensen, N.J., Astrup, A. (1998). Twenty-four-hour respiratory quotient: The role of diet and familial resemblance. Journal of Clinical Endocrinology and Metabolism, 83(8), 2758–2764.

    Article  PubMed  CAS  Google Scholar 

  70. Astrup, A., Buemann, B., Christensen, N.J., Toubro, S. (1994). Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women. American Journal of Physiology, 266(4 Pt 1), E592–E599.

    PubMed  CAS  Google Scholar 

  71. Larson, D.E., Ferraro, R.T., Robertson, D.S., Ravussin, E. (1995). Energy metabolism in weight-stable postobese individuals. American Journal of Clinical Nutrition, 62(4), 735–739.

    PubMed  CAS  Google Scholar 

  72. Froidevaux, F., Schutz, Y., Christin, L., Jequier, E. (1993). Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period. American Journal of Clinical Nutrition, 57(1), 35–42.

    PubMed  CAS  Google Scholar 

  73. Flatt, J.P. (1987). Dietary fat, carbohydrate balance, and weight maintenance: Effects of exercise. American Journal of Clinical Nutrition, 45(1 Suppl), 296–306.

    PubMed  CAS  Google Scholar 

  74. Pannacciulli, N., Salbe, A.D., Ortega, E., Venti, C.A., Bogardus, C., Krakoff, J. (2007). The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake. American Journal of Clinical Nutrition, 86(3), 625–632.

    PubMed  CAS  Google Scholar 

  75. Eckel, R.H., Hernandez, T.L., Bell, M.L., et al. (2006). Carbohydrate balance predicts weight and fat gain in adults. American Journal of Clinical Nutrition, 83(4), 803–808.

    PubMed  CAS  Google Scholar 

  76. Sims, E.A., Danforth, E., Jr., Horton, E.S., Bray, G.A., Glennon, J.A., Salans, L.B. (1973). Endocrine and metabolic effects of experimental obesity in man. Recent Progress in Hormone Research, 29, 457–496.

    PubMed  CAS  Google Scholar 

  77. Bouchard, C., Tremblay, A., Despres, J.P., et al. (1990). The response to long-term overfeeding in identical twins. New England Journal of Medicine, 322(21), 1477–1482.

    Article  PubMed  CAS  Google Scholar 

  78. Harper, M.E., Green, K., Brand, M.D. (2008). The efficiency of cellular energy transduction and its implications for obesity. Annual Review of Nutrition, 28, 13–33.

    Article  PubMed  CAS  Google Scholar 

  79. Lowell, B.B., & Spiegelman, B.M. (2000). Towards a molecular understanding of adaptive thermogenesis. Nature, 404(6778), 652–660.

    PubMed  CAS  Google Scholar 

  80. Rosenbaum, M., Vandenborne, K., Goldsmith, R., et al. (2003). Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 285(1), R183–R192.

    PubMed  CAS  Google Scholar 

  81. Weyer, C., Pratley, R.E., Salbe, A.D., Bogardus, C., Ravussin, E., Tataranni, P.A. (2000). Energy expenditure, fat oxidation, and body weight regulation: A study of metabolic adaptation to long-term weight change. Journal of Clinical Endocrinology and Metabolism, 85(3), 1087–1094.

    Article  PubMed  CAS  Google Scholar 

  82. de Jonge, L., & Bray, G.A. (1997). The thermic effect of food and obesity: A critical review. Obesity Research, 5(6), 622–631.

    PubMed  CAS  Google Scholar 

  83. Christin, L., O’Connell, M., Bogardus, C., Danforth, E., Jr., Ravussin, E. (1993). Norepinephrine turnover and energy expenditure in Pima Indian and white men. Metabolism, 42(6), 723–729.

    Article  PubMed  CAS  Google Scholar 

  84. Snitker, S., Tataranni, P.A., Ravussin, E. (1998). Respiratory quotient is inversely associated with muscle sympathetic nerve activity. Journal of Clinical Endocrinology and Metabolism, 83(11), 3977–3979.

    Article  PubMed  CAS  Google Scholar 

  85. Astrup, A., Buemann, B., Gluud, C., Bennett, P., Tjur, T., Christensen, N. (1995). Prognostic markers for diet-induced weight loss in obese women. International Journal of Obesity Related Metabolic Disorder, 19(4), 275–278.

    CAS  Google Scholar 

  86. Tataranni, P.A., Young, J.B., Bogardus, C., Ravussin, E. (1997). A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men. Obesity Research, 5(4), 341–347.

    PubMed  CAS  Google Scholar 

  87. Loos, R.J., & Bouchard, C. (2008). FTO: The first gene contributing to common forms of human obesity. Obesity Review, 9(3), 246–250.

    Article  CAS  Google Scholar 

  88. Loos, R.J., Lindgren, C.M., Li, S., et al. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics, 40(6), 768–775.

    Article  PubMed  CAS  Google Scholar 

  89. Cripps, R.L., Archer, Z.A., Mercer, J.G., Ozanne, S.E. (2007). Early life programming of energy balance. Biochemical Society Transactions, 35(Pt 5), 1203–1204.

    PubMed  CAS  Google Scholar 

  90. Uauy, R., Kain, J., Mericq, V., Rojas, J., Corvalan, C. (2008). Nutrition, child growth, and chronic disease prevention. Annals of Medicine, 40(1), 11–20.

    Article  PubMed  CAS  Google Scholar 

  91. Seale, P., & Lazar, M.A. (2009). Brown fat in humans: Turning up the heat on obesity. Diabetes, 58(7), 1482–1484.

    Article  PubMed  CAS  Google Scholar 

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Galgani, J., Ravussin, E. (2011). Principles of Human Energy Metabolism. In: Ahima, R. (eds) Metabolic Basis of Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1607-5_1

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