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Nitric Oxide (NO) and Cancer pp 253–263Cite as

Nitric Oxide Is a Promising Enhancer for Cancer Therapy

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

This report summarizes the present state of our knowledge pertaining to the nitric oxide (NO)-induced sensitization of tumor cell death. The effects of NO and its synergy with ionizing radiations, with members of the TNF family, and with chemotherapy have been investigated. The effect of NO-induced sensitization and the underlying molecular mechanisms are discussed.

Financial Support: Our group is supported by grants from Nièvre, Haute-Marne, Saône et Loire and Côte d’Or committees of the Ligue Nationale Contre le Cancer and from the Conseil Régional de Bourgogne.

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Notes

  1. 1.

    TGF: tumor growth factor.

  2. 2.

    DEA/NO: diethylamine nitric oxide.

  3. 3.

    GSNO: S-nitrosoglutathione.

  4. 4.

    SPERNO: spermine-NONOate.

  5. 5.

    Human T98G or U87 and rat C6 cells.

  6. 6.

    HCT-116 cancer cells.

  7. 7.

    SNU-1040 cancer cells.

  8. 8.

    SIN-1: 3-morpholinosydnonimine.

  9. 9.

    SCCVII/Ha.

  10. 10.

    FSaII fibrosarcoma.

  11. 11.

    ATR: ATM and Rad3-related.

  12. 12.

    VEGF: vascular endothelial growth factor.

  13. 13.

    TNF: tumor necrosis factor.

  14. 14.

    TRAIL: tumor necrosis factor-related apoptosis-inducing ligand.

  15. 15.

    FasL: ligand of Fas (CD95/APO-1 receptor).

  16. 16.

    IFN: interferon.

  17. 17.

    CH11: agonist anti-Fas antibody.

  18. 18.

    GTN: glyceryl trinitrate.

  19. 19.

    IAP: inhibitor of apoptosis.

  20. 20.

    SNP: sodium nitroprusside.

  21. 21.

    Nitrosylcobalamin, prodrug relatively tumor-specific due to higher transcobalamin receptor expression in tumor cells compared with normal tissue [32] that releases NO inside the cell.

  22. 22.

    Cap cells: DU145, PC-3, CL-1 and LNCaP cell lines.

  23. 23.

    XIAP, X-linked inhibitor of apoptosis.

  24. 24.

    PAPANO: 3-(2-hydroxy-2-nitroso-1-propyl hydrazino)-1-propanamine.

  25. 25.

    B-CLL: B-cell chronic lymphocytic leukemia.

  26. 26.

    MDR: multidrug resistance, MDR proteins, the main extrusion pump for hydrophobic drugs.

  27. 27.

    Substrates of glutathione-S-transferase that catalyze the conjugation of xenobiotics with reduced glutathione.

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Authors and Affiliations

  1. Laboratoire d’immunologie et immunothérapie des cancers, Université de Bourgogne, EPHE/Inserm, U866, Dijon, F-21000, France

    Marion Cortier, Lissbeth Leon, Néjia Sassi, Catherine Paul & Ali Bettaieb

  2. Laboratory of Cancer Immunology and Immunotherapy, Université de Bourgogne, EPHE/INSERM U866, 7 bd Jeanne d’Arc, Dijon, 21079, France

    Jean-François Jeannin

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  1. Marion Cortier
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  2. Lissbeth Leon
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  3. Néjia Sassi
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  4. Catherine Paul
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Correspondence to Jean-François Jeannin .

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  1. Dept. Microbiology, Immunology &, Molecular Genetics, University of California, Los Angeles, Charles E. Young Dr. E. 609, Los Angeles, 90095, California, USA

    Benjamin Bonavida

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Cortier, M., Leon, L., Sassi, N., Paul, C., Jeannin, JF., Bettaieb, A. (2010). Nitric Oxide Is a Promising Enhancer for Cancer Therapy. In: Bonavida, B. (eds) Nitric Oxide (NO) and Cancer. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1432-3_13

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