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Nitric Oxide (NO) and Cancer pp 189–207Cite as

Nitric Oxide: A Rate-Limiting Factor for Metastases Development

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Genomic and phenotypic instability associates with cancer cell heterogeneity. Although it has been argued that metastatic/invasive phenotypes are already present in primary tumors, highly aggressive and resistant cancer cell subsets may develop during in vivo growth and/or as a consequence of therapy. Moreover, factors such as the attack of our immune system or organ-specific microenvironments also affect cancer cell behavior and the subsequent response to drugs and/or other therapeutic agents. Interaction of cancer and endothelial cells in capillary beds initiates a cascade of molecular events that involve cytokines, growth factors, bioactive lipids, and reactive nitrogen and oxygen species (RNS and ROS) produced by either the cancer or the endothelial cells. Vascular endothelium-derived NO and H2O2 are not only cytotoxic for the cancer cells but also help to identify some critical molecular targets that appear essential for survival of invasive cells. Growing metastatic cells may keep adapting for survival in a sequence of molecular events where RNS play a key role.

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Authors and Affiliations

  1. Department of Physiology, University of Valencia, Valencia, Spain

    Angel Ortega & Salvador Mena

  2. Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, 15 Av. Blasco Ibañez, Valencia, 46010, Spain

    José M. Estrela

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  1. Angel Ortega
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  2. Salvador Mena
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  3. José M. Estrela
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Correspondence to José M. Estrela .

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  1. Dept. Microbiology, Immunology &, Molecular Genetics, University of California, Los Angeles, Charles E. Young Dr. E. 609, Los Angeles, 90095, California, USA

    Benjamin Bonavida

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Ortega, A., Mena, S., Estrela, J.M. (2010). Nitric Oxide: A Rate-Limiting Factor for Metastases Development. In: Bonavida, B. (eds) Nitric Oxide (NO) and Cancer. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1432-3_10

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