Abstract
Drug abuse is characterized not simply by abnormalities in reward seeking and compulsive use, but also a failure in inhibitory control. The mechanisms of reward seeking and behavioral inhibition are dissociable at the levels of genetic, neurobiological, and personality measurements. Social influences also play a key role in moderating the relationship between inhibitory processes and drug use. This concluding chapter extracts some of the key developments in this research area highlighted in each of the foregoing chapters and points out future challenges in harnessing this knowledge to find utility in the design and implementation of effective anti-drug prevention intervention strategies. General principles may also be derived for application to other health risk-related behaviors during childhood, adolescence, and young adulthood.
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Albert D, Steinberg L (2011) Peer Influences on Adolescent Risk Behavior. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Barkley R, Murphy K, Fischer M (2008) ADHD in adults: What the Science says. The Guildford Press, New York
Bierman KL (1996) Integrating social-skills training interventions with parent training and family-focused support to prevent conduct disorder in high-risk populations. The Fast Track Multisite Demonstration Project. The Conduct Problems Prevention Research Group. Ann N Y Acad Sci 794:256–64.
Biglan A, Fishbein D (2011) Implications for Translational Prevention Research: Science, Policy and Advocacy. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Carrion VG, Weems CF, Eliez S, Patwardhan A, Brown W, Ray RD, Reiss AL (2001) Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder. Biol Psychiatry 50:943–51
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002) Role of genotype in the cycle of violence in maltreated children. Science 297:851–54.
Churchwell J, Yurgelun-Todd D (2011) Neuroimaging, Adolescence and Risky Behavior. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Conrod PJ, Stewart SH, Comeau N, Maclean AM (2006) Efficacy of cognitive-behavioral interventions targeting personality risk factors for youth alcohol misuse. J Clin Child Adolesc Psychol 35:550–63. doi:10.1207/s15374424jccp3504_6
Cyders MA, Flory K, Rainer S, Smith GT (2009) The role of personality dispositions to risky behavior in predicting first-year college drinking. Addiction 104:193–202. doi:10.1111/j.1360-0443.2008.02434.x
De Bellis MD, Keshavan MS, Spencer S, Hall J (2000) N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD. Am J Psychiatry 157:1175–7
de Wit H (2009) Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addict Biol 14:22–31. doi:10.1111/j.1369-1600.2008.00129.x
de Wit H, Richards JB (2004) Dual determinants of drug use in humans: reward and impulsivity. Nebr Symp Motiv 50:19–55
Dishion TJ, Felver-Gant J, Abdullaev Y, Posner M (2011) Self-Regulation and Adolescent Drug Abuse: Translating Developmental Science and Neuroscience into Prevention Practice. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Dishion TJ, McCord J, Poulin F (1999) When interventions harm. Peer groups and problem behavior. Am Psychol 54:755–64
Doremus-Fitzwater TL, Varlinskaya EI, Spear LP (2010) Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors. Brain Cogn 72:114–23. doi:10.1016/j.bandc.2009.08.008
Fillmore M, Weafer J (2011) Impaired Inhibitory Control as a Mechanism of Drug Abuse. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Fishbein D (2000) The importance of neurobiological research to the prevention of psychopathology. Prev Sci 1:89–106
Fisher P, Bruce J, Abdullaev Y, Mannering A, Pears K (2011) Implications of Effects of Adversity on Development of Inhibitory Control for Design of Preventive Interventions and Potential Recovery of Function. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Ginexi E, Robertson E (2011) Translating Research on Inhibitory Control for the Prevention of Drug Abuse. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Goldman D, Oroszi G, Ducci F (2005) The genetics of addictions: uncovering the genes. Nat Rev Genet 6:521–32
Gullo M, Dawe S, McHugh M (2011) Impulsivity and adolescent substance use: From self-report measures to neuroimaging and beyond. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Gunnar MR, Fisher PA (2006) Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Dev Psychopathol 18:651–77
Ivanov I, Newcorn J, Morton K, Tricamo M (2011) Inhibitory control deficits in childhood: Definition, measurement, and clinical risk for substance use disorders. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Jacobs M, Jutras-Aswad D, DiNieri J, Tomasiewicz H, Hurd Y (2011) Genetic and environmental determinants of addiction risk related to impulsivity and its neurobiological substrates. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Jentsch J, Groman S, James A, Seu E (2011) Monaminergic Regulation of Cognitive Control in Laboratory Animals. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Kaffman A, Meaney MJ (2007) Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights. J Child Psychol Psychiatry 48:224–44. doi:10.1111/j.1469–7610.2007.01730.x
Lambert NM, Hartsough CS (1998) Prospective study of tobacco smoking and substance dependencies among samples of ADHD and non-ADHD participants. J Learn Disabil 31:533–44.
Lopez B, Schwartz SJ, Prado G, Campo AE, Pantin H (2008) Adolescent neurological development and its implications for adolescent substance use prevention. J Prim Prev 29:5–35. doi:10.1007/s10935–007–0119–3
Lynam D (2011) Inhibitory control as predictor for conduct disorders. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Lynam DR, Caspi A, Moffitt TE, Wikstrom PO, Loeber R, Novak S (2000) The interaction between impulsivity and neighborhood context on offending: the effects of impulsivity are stronger in poorer neighborhoods. J Abnorm Psychol 109:563–74
MacPherson L, Richards J, Anahi Collado C (2011) A Functional Analytic Framework for Understanding Adolescent Risk Taking Behavior. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Moffitt TE (1993) Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev 100:674–701
Molina BS, Hinshaw SP, Swanson JM, Arnold LE, Vitiello B, Jensen PS, Epstein JN, Hoza B, Hechtman L, Abikoff HB, Elliott GR, Greenhill LL, Newcorn JH, Wells KC, Wigal T, Gibbons RD, Hur K, Houck PR (2009) The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. J Am Acad Child Adolesc Psychiatry 48:484–500. doi:10.1097/CHI.0b013e31819c23d0
Pelham WE, Jr., Fabiano GA (2008) Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. J Clin Child Adolesc Psychol 37:184–214. doi:10.1080/15374410701818681
Perry JL, Carroll ME (2008) The role of impulsive behavior in drug abuse. Psychopharmacology (Berl) 200:1–26. doi:10.1007/s00213–008–1173–0
Richards JB, Gancarz A, Hawk Jr L (2011) Animal Models of Behavioral Processes that Underlie the Occurrence of Impulsice Behaviors in Humans. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Riggs N, Greenberg MT, Rhoades B (2011) Early Risk for Problem Behavior and Substance Use: Targeted interventions for the promotion of inhibitory control. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
Shedler J, Block J (1990) Adolescent drug use and psychological health. A longitudinal inquiry. Am Psychol 45:612–30
Slough NM, McMahon RJ, Bierman KL, Coie JD, Dodge KA, Foster EM, Greenberg MT, Lochman JE, Pinderhughes EE (2008) Preventing Serious Conduct Problems in School-Age Youths: The Fast Track Program. Cogn Behav Pract 15:3–17. doi:10.1016/j.cbpra.2007.04.002
Stairs DJ, Bardo MT (2009) Neurobehavioral effects of environmental enrichment and drug abuse vulnerability. Pharmacol Biochem Behav 92:377–82. doi:10.1016/j.pbb.2009.01.016
Trad PV (1993) The ability of adolescents to predict future outcome. Part I: Assessing predictive abilities. Adolescence 28:533–55
Verdejo-Garcia A, Bechara A, Recknor EC, Perez-Garcia M (2007) Negative emotion-driven impulsivity predicts substance dependence problems. Drug Alcohol Depend 91:213–9. doi:10.1016/j.drugalcdep.2007.05.025
Whiteside SP, Lynam DR (2003) Understanding the role of impulsivity and externalizing psychopathology in alcohol abuse: application of the UPPS impulsive behavior scale. Exp Clin Psychopharmacol 11:210–7
Zimmerman R, Donohew R, Palmgreen P, Noar S, Cupp P, Floyd B (2011) Designing media and classroom interventions targeting high sensation seeking or impulsive adolescents to prevent drug abuse and risky sexual behavior. In: Bardo MT, Fishbein D, Milich R (eds) Inhibitory Control and Drug Abuse Prevention: From Research to Translation. Springer, New York
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Bardo, M.T., Milich, R., Fishbein, D.H. (2011). Future Directions for Research on Inhibitory Control and Drug Abuse Prevention. In: Bardo, M., Fishbein, D., Milich, R. (eds) Inhibitory Control and Drug Abuse Prevention. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1268-8_17
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