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Interneuron Pathophysiologies: Paths to Neurodevelopmental Disorders

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Developmental Plasticity of Inhibitory Circuitry

Abstract

Clinical observations and retrospective studies in postmortem tissues indicate that cerebral cortical GABA systems are disrupted in a number of psychiatric and neurological disorders. Because GABAergic interneuron maturation is influenced substantially by activity-dependent mechanisms, it is unclear whether these associations are a cause or a consequence of a given disorder. Cortical GABA systems have received increased attention as targets of convergent pathophysiological processes because experimental manipulations of GABA systems in model organisms cause disturbances in the regulation of normal physiological activity, cognition and emotion. The disruptions often parallel certain dimensional components of clinical diagnoses, leading to testable hypotheses about the mechanisms through which altered development and maturation of GABAergic interneurons result in specific neurodevelopmental disorders.

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Acknowledgments

This work is supported by NICHD P30 grant HD15052, the Marino Autism Research Institute and NIMH grant MH067842.

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Authors and Affiliations

  1. Zilkha Neurogenetic Institute and the Department of Cell and Neurobiology, Keck School of Medicine at USC, 1501 San Pablo Street, Los Angeles, CA, 90089, USA

    Kathie L. Eagleson

  2. Vanderbilt Kennedy Center for Research on Human Development and the Department of Pharmacology, Vanderbilt University Medical Center, 8114 Medical Research Building III, 465 21st Avenue South, Nashville, TN, 37203, USA

    Elizabeth A. D. Hammock

  3. Zilkha Neurogenetic Institute and the Department of Cell and Neurobiology, Keck School of Medicine at USC, 1501 San Pablo Street, Los Angeles, CA, 90089, USA

    Pat Levitt

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  1. Kathie L. Eagleson
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  2. Elizabeth A. D. Hammock
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  3. Pat Levitt
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Corresponding author

Correspondence to Kathie L. Eagleson .

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  1. Dept. Biology, Georgia State University, Peachtree Center Ave. 24, Atlanta, 30303, U.S.A.

    Sarah L. Pallas

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Eagleson, K.L., Hammock, E.A.D., Levitt, P. (2010). Interneuron Pathophysiologies: Paths to Neurodevelopmental Disorders. In: Pallas, S. (eds) Developmental Plasticity of Inhibitory Circuitry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1243-5_9

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