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Muscle as a Target for Genetic Vaccine

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Muscle Gene Therapy

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Abstract

The complexity of microbe infections requires novel approaches to vaccine design. It is particularly challenging to develop a safe and effective vaccine against human immunodeficiency virus (HIV)-1. The versatility of DNA vaccination provides new perspectives. Recombinant subunit vaccines derived from adenoviruses and adeno-associated viruses are under extensive development as HIV-1 vaccines. For all of those vaccine vector platforms, muscle appears to be a practical, effective, and safe target. A vaccine strategy based on initial priming with DNA vaccine and/or viral vector vaccine and then boosting with a second viral vector vaccine has shown promise in HIV-1 vaccine development. The recent progress in DNA vaccines and viral vector subunit vaccines, particularly those derived from novel serotypes of adenovirus and adeno-associated virus, is reviewed here.

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Authors and Affiliations

  1. Department of Molecular Genetics and Microbiology, Gene Therapy Center, University of Massachusetts Medical School, 381 Plantation Street, Suite 250, Worcester, MA, 01605, USA

    Guangping Gao

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  1. Yan Zhi
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  2. Guangping Gao
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Correspondence to Guangping Gao .

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Editors and Affiliations

  1. Molecular Microbiology & Immunology, University of Missouri, Hospital Dr. 1, Columbia, 65212, U.S.A.

    Dongsheng Duan

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Zhi, Y., Gao, G. (2010). Muscle as a Target for Genetic Vaccine. In: Duan, D. (eds) Muscle Gene Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1207-7_14

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