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Computational Surgery and Dual Training pp 221–232Cite as

Modeling and Role of Leukocytes in Inflammation

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Abstract

Inflammation is a protective response of the body to infection or injury. When the body tissue is damaged by infection or injury, inflammatory response is triggered to remove the foreign invaders or start the healing process. In some diseases, such as atherosclerosis and rheumatoid arthritis, the inflammatory response is triggered inappropriately and the inflammatory cells damage the normal tissues. This suggests that those diseases can be treated by interfering with the inflammatory process.

Inflammation is manifested by pain, elevated temperature, redness, and swelling. Early events of the inflammation, which are usually independent of whether they are triggered by infection or injury, are changes of the volume (and blood flow rate as a result) and permeability of the blood vessel in the region of inflammation. Leukocytes are recruited from the blood stream to the site of inflammation, which are facilitated by the changed permeability of the vessel wall. Recruited leukocytes kill pathogens, and remove them by phagocytosis.

When the leukocytes migrate through the vessel wall, they change their shape so that they can pass through the narrow endothelial junctions. This means that the deformability of leukocytes is an important factor in the inflammatory process. Over the past several decades, our ability to characterize and simulate leukocyte deformability and behavior has tremendously improved. Some of these leukocyte models and simulation techniques are reviewed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA

    Minki Hwang

  2. Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA

    Scott A. Berceli

  3. Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, USA

    Scott A. Berceli

  4. Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA

    Roger Tran-Son-Tay

  5. Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA

    Roger Tran-Son-Tay

Authors
  1. Minki Hwang
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  2. Scott A. Berceli
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  3. Roger Tran-Son-Tay
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Corresponding author

Correspondence to Roger Tran-Son-Tay .

Editor information

Editors and Affiliations

  1. Dept. Computer Science, University of Houston, Calhoun Rd. 4800, Houston, 77204-3475, U.S.A.

    Marc Garbey

  2. Methodist Hospital Research Institute, Fannin St. 6565, Houston, 77030, U.S.A.

    Barbara Lee Bass

  3. ENSPS, Université Strasbourg I, boulevard Sébastien Brant, Illkirch, 67412, France

    Christophe Collet

  4. ENSPS, Université Louis Pasteur -Strasbourg I, Pôle API Boulevard. Sébastien Brant, Illkirch, 67400, France

    Michel Mathelin

  5. Dept. Mechanical & Aerospace Engineering, University of Florida, Gainesville, 32611-6250, U.S.A.

    Roger Tran-Son-Tay

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Hwang, M., Berceli, S.A., Tran-Son-Tay, R. (2010). Modeling and Role of Leukocytes in Inflammation. In: Garbey, M., Bass, B., Collet, C., Mathelin, M., Tran-Son-Tay, R. (eds) Computational Surgery and Dual Training. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1123-0_13

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  • DOI: https://doi.org/10.1007/978-1-4419-1123-0_13

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-1122-3

  • Online ISBN: 978-1-4419-1123-0

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