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RhoC GTPase in Cancer Progression and Metastasis

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The Rho GTPases in Cancer

Abstract

RhoC GTPase is more than 90% homologous to RhoA GTPase and was thought to have functions redundant to RhoA. Evidence over the years has demonstrated that despite their high degree of homology, RhoA and RhoC have distinct functions within the cell. Specifically, RhoC GTPase appears to be associated with particularly aggressive cancers and metastasis leading to increased migration and invasion. Unlike RhoA, expression and activation of RhoC appears to be dispensable for normal development and function. These attributes make RhoC a particularly attractive prognostic marker and potential antimetastatic target.

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  1. Center for Translational Cancer Research, Department of Biological Sciences, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, DE, USA

    Kenneth van Golen

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  1. Dept. Biological Sciences, University of Delaware, Newark, 19716, U.S.A.

    Kenneth Golen

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van Golen, K. (2010). RhoC GTPase in Cancer Progression and Metastasis. In: Golen, K. (eds) The Rho GTPases in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1111-7_8

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