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The HDL Receptor SR-BI

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High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease

Abstract

Scavenger receptor class B type I (SR-BI) was the first molecularly well-defined and functionally active cell surface HDL receptor to be described. SR-BI mediates the transfer of cholesterol from HDL to cells via a mechanism called selective lipid uptake. In vitro and in vivo studies have established that SR-BI is a physiologically relevant lipoprotein receptor. It plays an important role in HDL metabolism and reverse cholesterol transport and is a modulator of atherogenesis, indicating that the atheroprotective activity of HDL is partly mediated by SR-BI. Among other functions, SR-BI also participates in endothelial cell signaling, adrenal glucocorticoid production, and pathogen recognition. Given its significant physiologic and pathophysiological relevance in animal models as well as the human studies reported to date, it seems likely that SR-BI also plays a significant role in normal physiology, and alterations in its function may have consequences for pathology in humans. Further exploration of the structure, mechanism of action and function of SR-BI is likely to provide new insights into cholesterol metabolism in general and may ultimately lead to new strategies for prevention and/or treatment of atherosclerosis and other disease conditions.

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Acknowledgments

The work from the authors’ labs has been supported by grants from the U.S. National Institutes of Health and Fondo de Desarrollo Científico y Tecnológico (Chile). The authors are grateful for the many important contributions to this work by their many collaborators.

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  1. Biology Department, Massachusetts Institute of Technology, Room 68-483, 77 Massachusetts Ave, Cambridge, MA, 02139, USA

    Monty Krieger

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  1. Attilio Rigotti
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  2. Monty Krieger
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Correspondence to Monty Krieger .

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  1. Friedman School of Nutrition, Tufts University, Washington Street 711, Boston, 02111, USA

    Ernst J. Schaefer

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Rigotti, A., Krieger, M. (2010). The HDL Receptor SR-BI. In: Schaefer, E. (eds) High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1059-2_13

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  • DOI: https://doi.org/10.1007/978-1-4419-1059-2_13

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