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Schizophrenia as a Cognitive Disorder: Recent Approaches to Identifying its Core Cognitive Components to Aid Treatment Development

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Advances in Schizophrenia Research 2009

Abstract

In recent years the central role of cognitive deficits in schizophrenia has been increasingly accepted (Gold & Green, 2005; Green & Nuechterlein, 1999), so much so that the cognitive deficits have become very prominent new targets for treatment development (Gold, 2004; Hyman & Fenton, 2003). In this paper we examine factors that led to the conclusion that cognitive factors are core features of schizophrenia and then discuss recent approaches to identifying the cognitive domains and processes that offer promise as treatment targets.

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References

  • Andreasen, N. C., Paradiso, S., & O’Leary, D. S. (1998). Cognitive dysmetria as an integrative theory of schizophrenia: A dysfunction in cortical-subcortical-cerebellar circuitry. Schizophrenia Bulletin, 24, 203–218.

    CAS  PubMed  Google Scholar 

  • Barch, D. M., Berman, M. G., Engle, R., Jones, J. H., Jonides, J., Macdonald, A., 3rd, et al. (2009). CNTRICS final task selection: Working memory. Schizophrenia Bulletin, 35(1), 136–152.

    Article  PubMed  Google Scholar 

  • Barch, D. M., & Braver, T. S. (2005). Cognitive control in schizophrenia: Psychological and neural mechanisms. In R. W. Engle, G. Sedek, U. von Hecker & A. M. McIntosh (Eds.), Cognitive limitations in aging and psychopathology. New York: Cambridge University Press.

    Google Scholar 

  • Barch, D. M., Carter, C. S., Arnsten, A., Buchanan, R. W., Cohen, J. D., Geyer, M., et al. (2009). Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: Proceedings of the third CNTRICS meeting. Schizophrenia Bulletin, 35(1), 109–114.

    Article  PubMed  Google Scholar 

  • Bartzokis, G., Nuechterlein, K. H., Lu, P. H., Gitlin, M., Rogers, S., & Mintz, J. (2003). Dysregulated brain development in adult men with schizophrenia: A magnetic resonance imaging study. Biological Psychiatry, 53(5), 412–421.

    Article  PubMed  Google Scholar 

  • Carter, C. S., Barch, D. M., Buchanan, R. W., Bullmore, E., Krystal, J. H., Cohen, J., et al. (2008). Identifying cognitive mechanisms targeted for treatment development in schizophrenia: An overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biological Psychiatry, 64(1), 4–10.

    Article  PubMed  Google Scholar 

  • Chapman, L. J., & Chapman, J. P. (1978). The measurement of differential deficit. Journal of Psychiatric Research, 14, 303–311.

    Article  CAS  PubMed  Google Scholar 

  • Cornblatt, B., Obuchowski, M., Roberts, S., Pollack, S., & Erlenmeyer-Kimling, L. (1999). Cognitive and behavioral precursors of schizophrenia. Development and Psychopathology, 11, 487–508.

    Article  CAS  PubMed  Google Scholar 

  • Dickinson, D., & Harvey, P. D. (2009). Systemic hypotheses for generalized cognitive deficits in schizophrenia: A new take on an old problem. Schizophrenia Bulletin, 35(2), 403–414.

    Google Scholar 

  • Dickinson, D., Iannone, V. N., Wilk, C. M., & Gold, J. M. (2004). General and specific cognitive deficits in schizophrenia. Biological Psychiatry, 55(8), 826–833.

    Article  PubMed  Google Scholar 

  • Dickinson, D., Ragland, J. D., Calkins, M. E., Gold, J. M., & Gur, R. C. (2006). A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. Schizophrenia Research, 85(1–3), 20–29.

    Article  PubMed  Google Scholar 

  • Erlenmeyer-Kimling, L., Rock, D., Roberts, S. A., Janal, M., Kestenbaum, C., Cornblatt, B., et al. (2000). Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychosis: The New York High-Risk Project. American Journal of Psychiatry, 157 (9), 1416–1422.

    Article  CAS  PubMed  Google Scholar 

  • Geyer, M. A., & Tamminga, C. A. (2004). Measurement and treatment research to improve cognition in schizophrenia: Neuropharmacological aspects. Psychopharmacology, 174, 1–2.

    Article  CAS  Google Scholar 

  • Gold, J. M. (2004). Cognitive deficits as treatment targets in schizophrenia. Schizophrenia Research, 72(1), 21–28.

    Article  PubMed  Google Scholar 

  • Gold, J. M., Fuller, R. L., Robinson, B. M., Braun, E. L., & Luck, S. J. (2007). Impaired top-down control of visual search in schizophrenia. Schizophrenia Research, 94(1–3), 148–155.

    Article  PubMed  Google Scholar 

  • Gold, J. M., & Green, M. F. (2005). Neurocognition in Schizophrenia. In B. J. Sadock & V. A. Sadock (Eds.), Kaplan & Sadock’s comprehensive textbook of psychiatry (Vol. 8th, pp. 1436–1448). Baltimore: Lippincott, Williams & Wilkins.

    Google Scholar 

  • Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry, 153(3), 321–330.

    CAS  PubMed  Google Scholar 

  • Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J. (2000). Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the “right stuff”? Schizophrenia Bulletin, 26(1), 119–136.

    CAS  PubMed  Google Scholar 

  • Green, M. F., Kern, R. S., & Heaton, R. K. (2004). Longitudinal studies of cognition and functional outcome in schizophrenia: Implications for MATRICS. Schizophrenia Research, 72(1), 41–51.

    Article  PubMed  Google Scholar 

  • Green, M. F., & Nuechterlein, K. H. (1999). Should schizophrenia be treated as a neurocognitive disorder? Schizophrenia Bulletin, 25, 309–319.

    CAS  PubMed  Google Scholar 

  • Green, M. F., & Nuechterlein, K. H. (2004). The MATRICS initiative: Developing a consensus cognitive battery for clinical trials. Schizophrenia Research, 72(1), 1–3.

    Article  PubMed  Google Scholar 

  • Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., et al. (2004). Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria. Biological Psychiatry, 56(5), 301–307.

    Article  PubMed  Google Scholar 

  • Gur, R. E., Calkins, M. E., Gur, R. C., Horan, W. P., Nuechterlein, K. H., Seidman, L. J., et al. (2007). The consortium on the genetics of schizophrenia: Neurocognitive endophenotypes. Schizophrenia Bulletin, 33(1), 49–68.

    Article  PubMed  Google Scholar 

  • Hoff, A. L., Sakuma, M., Wieneke, M., Horon, R., Kushner, M., & DeLisi, L. E. (1999). Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. American Journal of Psychiatry, 156(9), 1336–1341.

    CAS  PubMed  Google Scholar 

  • Hyman, S., & Fenton, W. (2003). What are the right targets for psychopharmacology? 299, 350–351.

    CAS  Google Scholar 

  • Keefe, R. S., Bilder, R. M., Harvey, P. D., Davis, S. M., Palmer, B. W., Gold, J. M., et al. (2006). Baseline Neurocognitive Deficits in the CATIE Schizophrenia Trial. Neuropsychopharmacology, 31(9), 2033–2046.

    Google Scholar 

  • Kern, R. S., Green, M. F., Nuechterlein, K. H., & Deng, B. H. (2004). NIMH-MATRICS survey on assessment of neurocognition in schizophrenia. Schizophrenia Research, 72(1), 11–19.

    Article  PubMed  Google Scholar 

  • Kern, R. S., Nuechterlein, K. H., Green, M. F., Baade, L. E., Fenton, W. S., Gold, J. M., et al. (2008). The MATRICS Consensus Cognitive Battery, part 2: Co-norming and standardization. American Journal of Psychiatry, 165(2), 214–220.

    Article  PubMed  Google Scholar 

  • Luck, S. J., & Gold, J. M. (2008). The translation of cognitive paradigms for patient research. Schizophrenia Bulletin, 34, 629–644.

    Article  PubMed  Google Scholar 

  • MacDonald, A. W., 3rd, Carter, C. S., Flory, J. D., Ferrell, R. E., & Manuck, S. B. (2007). COMT val158Met and executive control: A test of the benefit of specific deficits to translational research. Journal of Abnormal Psychology, 116(2), 306–312.

    Article  PubMed  Google Scholar 

  • Nuechterlein, K. H., Asarnow, R. F., Subotnik, K. L., Fogelson, D. L., Ventura, J., Torquato, R., et al. (1998). Neurocognitive vulnerability factors for schizophrenia: Convergence across genetic risk studies and longitudinal trait/state studies. In M. F. Lenzenweger & R. H. Dworkin (Eds.), Origins and Development of Schizophrenia: Advances in Experimental Psychopathology (pp. 299–327). Washington, DC: American Psychological Association.

    Chapter  Google Scholar 

  • Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004). Identification of separable cognitive factors in schizophrenia. Schizophrenia Research, 72(1), 29–39.

    Article  PubMed  Google Scholar 

  • Nuechterlein, K. H., Dawson, M. E., Gitlin, M. J., Ventura, J., Goldstein, M. J., Snyder, K. S., et al. (1992). Developmental processes in schizophrenic disorders: Longitudinal studies of vulnerability and stress. Schizophrenia Bulletin, 18(3), 387–425.

    CAS  PubMed  Google Scholar 

  • Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., et al. (2008). The MATRICS Consensus Cognitive Battery, part 1: Test selection, reliability, and validity. American Journal of Psychiatry, 165(2), 203–213.

    Article  PubMed  Google Scholar 

  • Nuechterlein, K. H., Pashler, H. E., & Subotnik, K. L. (2006). Translating basic attentional paradigms to schizophrenia research: Reconsidering the nature of the deficits. Development and Psychopathology, 18(3), 831–851.

    Article  PubMed  Google Scholar 

  • Rund, B. R. (1998). A review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophrenia Bulletin, 24(3), 425–435.

    CAS  PubMed  Google Scholar 

  • Sergi, M. J., Rassovsky, Y., Nuechterlein, K. H., & Green, M. F. (2006). Social perception as a mediator of the influence of early visual processing on functional status in schizophrenia. American Journal of Psychiatry, 163(3), 448–454.

    Article  PubMed  Google Scholar 

  • Snitz, B. E., MacDonald, A. W., 3rd, & Carter, C. S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes. Schizophrenia Bulletin, 32(1), 179–194.

    Article  PubMed  Google Scholar 

  • Strauss, M. E., & Summerfelt, A. (2003). The neuropsychological study of schizophrenia: A methodological perspective. In M. F. Lenzenweger & J. M. Hooley (Eds.), Principles of experimental psychopathology: Essays in honor of Brendan A. Maher (pp. 119–134). Washington DC: American Psychological Association.

    Chapter  Google Scholar 

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Correspondence to Keith H. Nuechterlein .

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Nuechterlein, K.H., Green, M.F., Kern, R.S. (2010). Schizophrenia as a Cognitive Disorder: Recent Approaches to Identifying its Core Cognitive Components to Aid Treatment Development. In: Gattaz, W., Busatto, G. (eds) Advances in Schizophrenia Research 2009. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0913-8_14

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  • DOI: https://doi.org/10.1007/978-1-4419-0913-8_14

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