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Experimental Animal Models for Studying Lung Cancer

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Lung Cancer Metastasis

Abstract

Lung cancer is the leading cause of cancer-related mortality for both men and women worldwide. The use of animal models of lung cancer is necessary to improve our understanding of lung tumor biology and facilitate novel therapies and diagnostics. To this end, animal models should mimic both the genetic alterations found in human lung tumors and their histological characteristics. Currently, several types of animal models are widely used for experimental lung cancer research. These include chemically induced lung tumors, transgenic mouse models, and human tumor xenografts. A single model system that faithfully recaptures the entire spectrum of lung cancer biology is unlikely to exist. Different models that accurately reflect the various aspects of the disease are necessary to properly investigate such a complex disease. Tumorigenesis, proliferation, invasion, angiogenesis, metastasis, prevention, and therapy are all areas where specific models are required to ensure proper experimental design.

The purpose of this chapter is to summarize the various lung cancer model systems in use today and define both their utility and limitations. We will briefly describe all of these models and provide a more detailed description of the orthotopic lung cancer xenograft models.

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Authors and Affiliations

  1. Division of Applied Molecular Oncology, Princess Margaret Hospital, University Health Network, M5G 2M9, Toronto, Ontario, Canada

    Jiang Liu

  2. Division of Thoracic Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada

    Michael R. Johnston MD

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Correspondence to Jiang Liu .

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Editors and Affiliations

  1. Dept. Internal Medicine, University of Michigan Health System, Zina Pitcher Place 109, Ann Arbor, 48109-2200, U.S.A.

    Venkateshwar Keshamouni

  2. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Douglas Arenberg

  3. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Gregory Kalemkerian

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Liu, J., Johnston, M.R. (2009). Experimental Animal Models for Studying Lung Cancer. In: Keshamouni, V., Arenberg, D., Kalemkerian, G. (eds) Lung Cancer Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0772-1_12

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