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Cooperation and Cancer

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Cancer Genome and Tumor Microenvironment

Part of the book series: Cancer Genetics ((CANGENETICS))

Abstract

The preceding chapters detail how mutations in genes such as PDGFB, CDH1, TGFBR1, KRAS shape tumor microenvironment. Chapter 19 further demonstrates that multiple mutations targeting parallel pathways readily occur in the same tumor. Do they arise and function independently or do they interact, coevolve, and influence tumor progression in concert? Some answers to this broad question could be found in the concluding chapter of the volume.

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References

  • Axelrod R and Hamilton WD. 1981. The evolution of cooperation. Science 211:1390–1396.

    Article  PubMed  CAS  Google Scholar 

  • Axelrod R, Axelrod DE, Pienta KJ. 2006. Evolution of cooperation among tumor cells. Proc Natl Acad Sci U S A 103:13474–13479.

    Article  PubMed  CAS  Google Scholar 

  • Barrett MT, Sanchez CA, Prevo LJ, Wong DJ, Galipeau PC, Paulson TG, Rabinovitch PS, Reid BJ. 1999. Evolution of neoplastic cell lineages in Barrett oesophagus. Nat Genet 22:106–109.

    Article  PubMed  CAS  Google Scholar 

  • Bird A. 2002. DNA methylation patterns and epigenetic memory. Genes Dev 16:6–21.

    Article  PubMed  CAS  Google Scholar 

  • Bull JJ and Rice WR. 1991. Distinguishing mechanisms for the evolution of co-operation. J Theor Biol 149:63–74.

    Article  PubMed  CAS  Google Scholar 

  • Buss LW. 1987. The Evolution of Individuality. Princeton University Press, Princeton NJ

    Google Scholar 

  • Bussard KM, Gay CV, Mastro AM. 2008. The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Rev 27:41–55.

    Article  PubMed  Google Scholar 

  • Cairns J. 1975. Mutation selection and the natural history of cancer. Nature 255:197–200.

    Article  PubMed  CAS  Google Scholar 

  • Castro MA, Onsten TT, de Almeida RM, Moreira JC. 2005. Profiling cytogenetic diversity with entropy-based karyotypic analysis. J Theor Biol 234:487–495.

    Article  PubMed  CAS  Google Scholar 

  • Chambers TJ. 2000. Regulation of the differentiation and function of osteoclasts. J Pathol 192:4–13.

    Article  PubMed  CAS  Google Scholar 

  • Coffey RJ Jr, Goustin AS, Soderquist AM, Shipley GD, Wolfshohl J, Carpenter G, Moses HL. 1987. Transforming growth factor alpha and beta expression in human colon cancer lines: Implications for an autocrine model. Cancer Res 47:4590–4594.

    PubMed  CAS  Google Scholar 

  • Condeelis J, Singer RH, Segall JE. 2005. The great escape: When cancer cells hijack the genes for chemotaxis and motility. Annu Rev Cell Dev Biol 21:695–718.

    Article  PubMed  CAS  Google Scholar 

  • Dawkins R. 1976. The Selfish Gene. Oxford: Oxford University Press.

    Google Scholar 

  • Diggle SP, Griffin AS, Campbell GS, West SA. 2007. Cooperation and conflict in quorum-sensing bacterial populations. Nature 450:411–414.

    Article  PubMed  CAS  Google Scholar 

  • Feinberg AP. 2007. Phenotypic plasticity and the epigenetics of human disease. Nature 447:433–440.

    Article  PubMed  CAS  Google Scholar 

  • Foster KR and Wenseleers T. 2006. A general model for the evolution of mutualisms. J Evol Biol 19:1283–1293.

    Article  PubMed  CAS  Google Scholar 

  • Frank SA. 1998. Foundations of Social Evolution. Princeton University Press, Princeton, NJ 268

    Google Scholar 

  • Frank SA. 2007. All of life is social. Curr Biol 17:R648–650.

    Article  PubMed  CAS  Google Scholar 

  • Frumkin D, Wasserstrom A, Itzkovitz S, Stern T, Harmelin A, Eilam R, Rechavi G, Shapiro E. 2008. Cell Lineage Analysis of a Mouse Tumor. Cancer Res 68:5924–5931.

    Article  PubMed  CAS  Google Scholar 

  • Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E. 2007. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nature Cell Biology 9:1392–1400.

    Article  PubMed  CAS  Google Scholar 

  • Gatenby RA and Gillies RJ. 2004. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891–899.

    Article  PubMed  CAS  Google Scholar 

  • Gatenby RA and Vincent TL. 2003. Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies. Mol Cancer Ther 2:919–927.

    PubMed  CAS  Google Scholar 

  • Gillies RJ and Gatenby RA. 2007. Adaptive landscapes and emergent phenotypes: Why do cancers have high glycolysis? J Bioenerg Biomembr 39:251–257.

    Article  PubMed  CAS  Google Scholar 

  • González-García I, Solé RV, Costa J. 2002. Metapopulation dynamics and spatial heterogeneity in cancer. Proc Natl Acad Sci U S A 99:13085–13089.

    Article  PubMed  Google Scholar 

  • Griffin AS, West SA, Buckling A. 2004. Cooperation and competition in pathogenic bacteria. Nature 430:1024–1027.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton WD. 1964a. The genetical evolution of social behaviour. I. J Theor Biol 7:1–16.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton WD. 1964b. The genetical evolution of social behaviour. II. J Theor Biol 7:17–52.

    Article  PubMed  CAS  Google Scholar 

  • Hanahan D and Weinberg RA. 2000. The hallmarks of cancer. Cell 100:57–70.

    Article  PubMed  CAS  Google Scholar 

  • Harada T, Okita K, Shiraishi K, Kusano N, Kondoh S, Sasaki K. 2002. Interglandular cytogenetic heterogeneity detected by comparative genomic hybridization in pancreatic cancer. Cancer Res 62:835–839.

    PubMed  CAS  Google Scholar 

  • Heppner G, Miller B, Cooper D, Miller FR. 1980. Growth interactions between mammary tumor cells. Cell Biology of Breast Cancer:161–172.

    Google Scholar 

  • Hicklin DJ and Ellis LM. 2005. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011–1027.

    Article  PubMed  CAS  Google Scholar 

  • Jones PA and Takai D. 2001. The role of DNA methylation in mammalian epigenetics. Science 293:1068–1070.

    Article  PubMed  CAS  Google Scholar 

  • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. 2007. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449:557–563.

    Article  PubMed  CAS  Google Scholar 

  • Kim K and Shibata D. 2004. Tracing ancestry with methylation patterns: Most crypts appear distantly related in normal adult human colon. BMC Gastroenterol 4:8.

    Article  PubMed  Google Scholar 

  • Larue L. 2008. P13K/AKT pathway and Epithelial–mesenchymal Transition This Volume.

    Google Scholar 

  • Larue L and Bellacosa A. 2005. Epithelial–mesenchymal transition in development and cancer: Role of phosphatidylinositol 3’ kinase/AKT pathways. Oncogene 24:7443–7454.

    Article  PubMed  CAS  Google Scholar 

  • Lee DC, Fenton SE, Berkowitz EA, Hissong MA. 1995. Transforming growth factor alpha: Expression, regulation, and biological activities. Pharmacol Rev 47:51–85.

    PubMed  CAS  Google Scholar 

  • Lehmann L and Keller L. 2006. The evolution of cooperation and altruism–a general framework and a classification of models. J Evol Biol 19:1365–1376.

    Article  PubMed  CAS  Google Scholar 

  • Lewis CE and Pollard JW. 2006. Distinct role of macrophages in different tumor microenvironments. Cancer Res 66:605–612.

    Article  PubMed  CAS  Google Scholar 

  • Lien W-H and Vasioukhin V. 2008. Cadherin–catenin complexes in tumor progression. This Volume

    Google Scholar 

  • Lien WH, Klezovitch O, Vasioukhin V. 2006. Cadherin–catenin proteins in vertebrate development. Curr Opin Cell Biol 18:499–506.

    Article  PubMed  CAS  Google Scholar 

  • Loberg RD, Ying C, Craig M, Day LL, Sargent E, Neeley C, Wojno K, Snyder LA, Yan L, Pienta KJ. 2007. Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo. Cancer Res 67:9417–9424.

    Article  PubMed  CAS  Google Scholar 

  • Maley CC. 2007. Multistage carcinogenesis in Barrett’s esophagus. Cancer Lett 245:22–32.

    Article  PubMed  CAS  Google Scholar 

  • Maley CC, Galipeau PC, Finley JC, Wongsurawat VJ, Li X, Sanchez CA, Paulson TG, Blount PL, Risques RA, Rabinovitch PS, Reid BJ. 2006. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet 38:468–473.

    Article  PubMed  CAS  Google Scholar 

  • Mancini A and Di Battista JA. 2006. Transcriptional regulation of matrix metalloprotease gene expression in health and disease. Front Biosci 11:423–446.

    Article  PubMed  CAS  Google Scholar 

  • Merlo LMF, Pepper JW, Reid BJ, Maley CC. 2006. Cancer as an evolutionary and ecological process. Nat Rev Cancer 6:924–935.

    Article  PubMed  CAS  Google Scholar 

  • Merritt AJ, Gould KA, Dove WF. 1997. Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages. Proc Natl Acad Sci U S A 94:13927–13931.

    Article  PubMed  CAS  Google Scholar 

  • Montel V, Mose E, Tarin D. 2006. Tumor-stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis. Int J Cancer 119:251–263.

    Article  PubMed  CAS  Google Scholar 

  • Murphy DS, Hoare SF, Going JJ, Mallon EE, George WD, Kaye SB, Brown R, Black DM, Keith WN. 1995. Characterization of extensive genetic alterations in ductal carcinoma in situ by fluorescence in situ hybridization and molecular analysis. J Natl Cancer Inst 87:1694–1704.

    Article  PubMed  CAS  Google Scholar 

  • Newton MA. 2006. On estimating the polyclonal fraction in lineage-marker studies of tumor origin. Biostatistics 7:503–514.

    Article  PubMed  Google Scholar 

  • Novelli MR, Williamson JA, Tomlinson IP, Elia G, Hodgson SV, Talbot IC, Bodmer WF, Wright NA. 1996. Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science 272:1187–1190.

    Article  PubMed  CAS  Google Scholar 

  • Nowak MA. 2006. Evolutionary Dynamics. The Belknap Press of Harvard University Press, Cambridge, MA

    Google Scholar 

  • Nowell PC. 1976. The clonal evolution of tumor cell populations. Science 194:23–28.

    Article  PubMed  CAS  Google Scholar 

  • Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. 2006. Type II cadherin ectodomain structures: Implications for classical cadherin specificity. Cell 124:1255–1268.

    Article  PubMed  CAS  Google Scholar 

  • Pederson L, Winding B, Foged NT, Spelsberg TC, Oursler MJ. 1999. Identification of breast cancer cell line-derived paracrine factors that stimulate osteoclast activity. Cancer Res 59:5849–5855.

    PubMed  CAS  Google Scholar 

  • Pepper JW, Sprouffske K, Maley CC. 2007. Animal Cell Differentiation Patterns Suppress Somatic Evolution. PLoS Comput Biol 3:e250.

    Article  PubMed  Google Scholar 

  • Perrais M, Chen X, Perez-Moreno M, Gumbiner BM. 2007. E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions. Mol Biol Cell 18:2013–2025.

    Article  PubMed  CAS  Google Scholar 

  • Pietras K, Pahler J, Bergers G, Hanahan D. 2008. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 5:e19

    Article  PubMed  Google Scholar 

  • Queller DC. 1985. Kinship, reciprocity and synergism in the evolution of social behaviour. Nature 318:366–367.

    Article  Google Scholar 

  • Rainey PB and Travisano M. 1998. Adaptive radiation in a heterogeneous environment. Nature 394:69–72.

    Article  PubMed  CAS  Google Scholar 

  • Ren B, Yee KO, Lawler J, Khosravi-Far R. 2006. Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta 1765:178–188.

    PubMed  CAS  Google Scholar 

  • Sachs JL, Mueller UG, Wilcox TP, Bull JJ. 2004. The evolution of cooperation. The Quarterly Review of Biology 79:135–160.

    Article  PubMed  Google Scholar 

  • Sahai E. 2005. Mechanisms of cancer cell invasion. Curr Opin Genet Dev 15:87–96.

    Article  PubMed  CAS  Google Scholar 

  • Salipante SJ, Thompson JM, Horwitz MS. 2008. Phylogenetic fate mapping: Theoretical and experimental studies applied to the development of mouse…. Genetics 178: 967–977.

    Google Scholar 

  • Smith JA and Szathmáry E. 1997. The Major Transitions in Evolution. books.google.com

    Google Scholar 

  • Tanaka S, Imanishi K, Yoshihara M, Haruma K, Sumii K, Kajiyama G, Akamatsu S. 1991. Immunoreactive transforming growth factor alpha is commonly present in colorectal neoplasia. Am J Pathol 139:123–129.

    PubMed  CAS  Google Scholar 

  • Taylor PD. 1992. Altruism in viscous populations—an inclusive fitness model. Evolutionary Ecology 6: 352–356.

    Google Scholar 

  • Taylor PD and Frank SA. 1996. How to make a kin selection model. J Theor Biol 180:27–37.

    Article  PubMed  CAS  Google Scholar 

  • Tlsty TD. 2001. Stromal cells can contribute oncogenic signals. Semin Cancer Biol 11:97–104.

    Article  PubMed  CAS  Google Scholar 

  • Trivers RL. 1971. The Evolution of Reciprocal Altruism. The Quarterly Review of Biology 46:35–57.

    Article  Google Scholar 

  • Tsao JL, Yatabe Y, Salovaara R, Järvinen HJ, Mecklin JP, Aaltonen LA, Tavaré S, Shibata D. 2000. Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A 97:1236–1241.

    Article  PubMed  CAS  Google Scholar 

  • Turley E, Veiseh M, Radisky D, Bissell M. 2008. Mechanisms of disease: Epithelial–mesenchymal transition–does cellular plasticity fuel neoplastic progression? Nat Clin Prac Oncol 5:280–290.

    Article  CAS  Google Scholar 

  • Wasserstrom A, Frumkin D, Adar R, Itzkovitz S, Stern T, Kaplan S, Shefer G, Shur I, Zangi L, Reizel Y, Harmelin A, Dor Y, Dekel N, Reisner Y, Benayahu D, Tzahor E, Segal E, Shapiro E. 2008. Estimating cell depth from somatic mutations. PLoS Comput Biol 4:e1000058.

    Article  PubMed  Google Scholar 

  • West SA, Griffin AS, Gardner A. 2007. Social semantics: Altruism, cooperation, mutualism, strong reciprocity and group selection. J Evol Biol 20:415–432.

    Article  PubMed  CAS  Google Scholar 

  • West SA, Griffin AS, Gardner A, Diggle SP. 2006. Social evolution theory for microorganisms. Nat Rev Microbiol 4:597–607.

    Article  PubMed  CAS  Google Scholar 

  • Wyckoff JB, Jones JG, Condeelis JS, Segall JE. 2000. A critical step in metastasis: In vivo analysis of intravasation at the primary tumor. Cancer Res 60:2504–2511.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Genomics & Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA

    Kathleen Sprouffske

  2. Department of Cellular and Molecular Oncology, Wister Institute, Philadelphia, PA, USA

    Carlo C. Maley

Authors
  1. Kathleen Sprouffske
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  2. Carlo C. Maley
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Correspondence to Carlo C. Maley .

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Editors and Affiliations

  1. Children's Hospital of Philadelphia, Civic Center Blvd. 3615, Philadelphia, 19104, U.S.A.

    Andrei Thomas-Tikhonenko

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Sprouffske, K., Maley, C.C. (2010). Cooperation and Cancer. In: Thomas-Tikhonenko, A. (eds) Cancer Genome and Tumor Microenvironment. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0711-0_20

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