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Epigenetics of Aging pp 345–369Cite as

Epigenetic Silencing of Progeroid Syndromes

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Abstract

The risk of developing cancer increases with age, and the accumulation of epigenetic modifications has been found to be an important factor in tumorigenesis. A global loss of DNA methylation is detected both in aging and in cancer, and promoter hypermethylation is associated with the silencing of genes with roles both in tumor suppression and in progeria, such as the Werner syndrome (WRN) and lamin A/C (LMNA) genes. The epigenetic inactivation of these two genes in different tumors demonstrated for the first time that genes involved in the aging process could also be of crucial importance in the development of human cancer. In this review, I will explore the physiological significance of these epigenetic modifications during aging and the neoplastic process.

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Acknowledgments

I carried out the research involving the epigenetic silencing of progeroid genes in the Cancer Epigenetics Laboratory, directed by Dr. Manel Esteller at the CNIO (National Spanish Cancer Centre, Madrid). I would like to address special thanks to Manel Esteller for his friendship and for sharing days of exciting discoveries during my post-doctoral stage in his laboratory. I would also like to thank two anonymous reviewers for useful suggestions.

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  1. Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, 1030, Vienna, Austria

    Ruben Agrelo

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  1. Ruben Agrelo
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Correspondence to Ruben Agrelo .

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  1. Dept. Biology, University of Alabama, Birmingham, University Blvd. 1300, Birmingham, 35294-1170, U.S.A.

    Trygve O. Tollefsbol

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Agrelo, R. (2010). Epigenetic Silencing of Progeroid Syndromes. In: Tollefsbol, T. (eds) Epigenetics of Aging. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0639-7_19

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