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Dermatology pp 1–25Cite as

Basic Science and Immunology

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Abstract

Functions as a mechanical and antimicrobial barrier; protects against water loss and provides immunological protection; thickness varies from 0.04 mm (eyelid skin) to 1.5 mm (palmoplantar skin).

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References

  1. Archer CB. Functions of the skin. In: Burns T, Cox N, Griffith C, Breathnach S, eds.Rook’s Textbook of Dermatology. 7th ed. Malden, MA: Blackwell Science Ltd; 2004:129-140.

    Chapter  Google Scholar 

  2. Barker J, McGrath J.Cell Adhesion and Migration in Skin Disease. Netherlands: Gordon and Breach Publishing Company; 2001:76.

    Book  Google Scholar 

  3. Baumann L, Saghari S. Basic science of the epidermis. In: Baumann L, ed.Cosmetic Dermatology: Principles and Practice. 2nd ed. New York, NY: McGraw-Hill Professional; 2009:3-7.

    Google Scholar 

  4. Baumann L, Saghari S. Basic science of the dermis. In: Baumann L, ed.Cosmetic Dermatology: Principles and Practice. 2nd ed. New York, NY: McGraw-Hill Professional; 2009:8-13.

    Google Scholar 

  5. Bittar EE, Bittar N.Principles of Medical Biology: Developmental Biology. Greenwich, CT: Jai Press Inc; 1998.

    Google Scholar 

  6. Bouwstra JA, Pilgram GS, Ponec M. Struture of the skin barrier. In: Elias PM, Feingold KR, eds.Skin Barrier. New York, NY: Taylor & Francis Group; 2006:65-89.

    Google Scholar 

  7. Chong BF, Kupper TS. The cutaneous immune system: a skin-based perspective on immunology. In: Sontheimer RD, Provost TT, eds.Cutaneous Manifestations of Rheumatic Diseases. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004.

    Google Scholar 

  8. Draelos ZD.Cosmetic Dermatology: Products and Procedures. Hoboken, NJ: Blackwell Publishing Ltd; 2010:547-550.

    Book  Google Scholar 

  9. Fine JD. Basement membrane proteins. In: Leigh IM, Birgitte-Lane E, Watt FM, eds.The Keratinocyte Handbook. New York, NY: Cambridge University Press; 1994:181-193.

    Google Scholar 

  10. Fradette J, Germain L, Seshaiah P, Coulombe PA. The Type I keratin 19 possesses distinct and context-dependent assembly properties.J Cell Sci. 1998;273(52):35176-35184.

    CAS  Google Scholar 

  11. Gaspari AA, Tyrine SK, eds.Clinical and Basic Immunodermatology. New York, NY: Springer; 2008:8-10. 67–73, 132–134.

    Google Scholar 

  12. Glaser R, Harder J, Lange H, Bartels J, Christophers E, Schroder JM. Antimicrobial psoriasin protects human skin fromEscherichia coli infection.Nat Immunol. 2004;6:57-64.

    Article  PubMed  Google Scholar 

  13. Graham-Brown R, Burns T.Lecture Notes: Dermatology. 9th ed. Malden, MA: Blackwell Science Ltd; 2007:1-9.

    Google Scholar 

  14. Hanakawa Y, Amagai M, Shirakata Y, Sayama K, Hashimoto K. Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes.J Cell Sci. 2000;113:1803-1811.

    PubMed  CAS  Google Scholar 

  15. Hermann H, Bar H, Kreplak L, Strelkov SV, Aebi U. Intermediate filaments: from cell architecture to nanomechanics.Nat Rev Mol Cell Biol. 2007;8(7):562-573.

    Article  Google Scholar 

  16. Hoath SB, Leahy DG. The organization of human epidermis: functional epidermal units and phi proportionality.J Investig Dermatol. 2003;12(1):1440-1446.

    Article  Google Scholar 

  17. Hogg N, Laschinger M, Giles K, McDowall A. T-cell integrins: more than just sticking points.J Cell Sci. 2003;116:4695-4705.

    Article  PubMed  CAS  Google Scholar 

  18. Jalian HR, Kim J. Immunology of the skin. In: Baumann L, ed.Cosmetic Dermatology: Principles and Practice. 2nd ed. New York, NY: McGraw-Hill Professional; 2009:22-28.

    Google Scholar 

  19. Jonkman MF, Pasmooij AM, Pasmans SG, et al. Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa.Am J Hum Genet. 2005;77:653-660.

    Article  PubMed  CAS  Google Scholar 

  20. Jullien D, Modlin RL, Nicolas JF. The skin immune system. In: Euvrard S, Kanitakis J, Claudy A, eds.Skin Diseases After Organ Transplantation. Montrouge: John Libbey Eurotext; 1998:9-13.

    Google Scholar 

  21. Kalinin A, Marekov LN, Steinert P. Assembly of the epidermal cornified cell envelope.J Cell Sci. 2001;114:3069-3070.

    PubMed  CAS  Google Scholar 

  22. Kanitakis J. Anatomy, histology and immunohistochemistry of normal human skin.Eur J Dermatol. 2002;12(4):390-401.

    PubMed  Google Scholar 

  23. Kim HM, Kang DK, Kim HY, Kang SS, Chang SI. Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells.Biochem Biophys Res Commun. 2007;352(2):509-513.

    Article  PubMed  CAS  Google Scholar 

  24. Lan L, Hayes CS, Laury-Kleintop L, Gilmour SK. Suprabasal induction of ornithine decarboxylase in adult mouse skin is sufficient to activate keratinocytes.J Investig Dermatol. 2005;124:602-614.

    Article  PubMed  CAS  Google Scholar 

  25. Lan L, Hayes CS, Laury-Kleintop L, Gilmour SK. Suprabasal induction of ornithine decarboxylase in adult mouse skin is sufficient to activate keratinocytes.J Investig Dermatol. 2005;124:602-614.

    Article  PubMed  CAS  Google Scholar 

  26. Lantz CS, Boesiger J, Song CH, et al. Role for interleukin-3 in mast cell and basophil development and in immunity to parasites.Nature. 1998;392(6671):90-93.

    Article  PubMed  CAS  Google Scholar 

  27. Li D, Li J, Duan Y, Zhou X. Expression of LL-37, human beta defensin-2, and CCR6 mRNA in patients with psoriasis vulgaris.J Huazhong Univ Sci Technol Med Sci. 2004;24(4):404-406.

    Article  PubMed  Google Scholar 

  28. Loomis CA, Koss T. Embryology. In: Bolognia JL, Jorizzo JL, Rapini RP, eds.Dermatology. 2nd ed. St. Louis, MO: Mosby Elsevier; 2008:39-48.

    Google Scholar 

  29. McGrath JA, Eady RA, Pope FM. Anatomy and organization of human skin. In: Burns T, Cox N, Griffith C, Breathnach S, eds.Rook’s Textbook of Dermatology. 7th ed. Malden, MA: Blackwell Science Ltd; 2004:45-60.

    Chapter  Google Scholar 

  30. Michel M, Torok N, Godbout MJ, et al. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage.J Cell Sci. 1996;109(5):1017-1028.

    PubMed  CAS  Google Scholar 

  31. Misery L, Dezutter-Dambuyant C. Precursors of Langerhans cells.Eur Acad Derm Venerol. 2006;5(2):124-131.

    Article  Google Scholar 

  32. Ong PY, Ohtake T, Brandt C, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis.N Engl J Med. 2002;347(15):1151-1160.

    Article  PubMed  CAS  Google Scholar 

  33. Paul WE.Fundamental Immunology. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008:1399-1410.

    Google Scholar 

  34. Price CJ, Green J, Kirsner RS. Mastocytosis in children is associated with mutations in c-KIT.J Investig Dermatol. 2010;130:639.

    Article  PubMed  CAS  Google Scholar 

  35. Saed G, Fivenson DP, Naidu Y, Ncikoloff BJ. Mycosis fungoides exhibits a Th1-type cell mediated cytokine profile whereas Sezary syndrome expresses a Th-2 type profile.J Investig Dermatol. 1994;103(1):29-33.

    Article  PubMed  CAS  Google Scholar 

  36. Schwarz T. Immunology. In: Bolognia JL, Jorizzo JL, Rapini RP, eds.Dermatology. 2nd ed. St. Louis, MO: Mosby Elsevier; 2008:65-79.

    Google Scholar 

  37. Schweizer J, Bowden PE, Coulombe PA, et al. New consensus nomenclature for mammalian keratins.J Cell Biol. 2006;174(2):169-174.

    Article  PubMed  CAS  Google Scholar 

  38. Sholl LM, Hornick JL, Pinkus JL, Pinkus GS, Padera RA. Immunohistochemical analysis of langerin in langerhans cell histiocytosis and pulmonary inflammatory and infectious diseases.Am J Surg Pathol. 2007;31(6):947-952.

    Article  PubMed  Google Scholar 

  39. Stingl G, Shevach EM. Langerhans cells as antigen-presenting cells. In: Schuler G, ed.Epidermal Langerhans Cells. Boca Raton, FL: CRC Press Inc; 1991:159-178.

    Google Scholar 

  40. Stingl G. Introduction to basic science. In: Bolognia JL, Jorizzo JL, Rapini RP, eds.Dermatology. 2nd ed. St. Louis, MO: Mosby Elsevier; 2008:23-36.

    Google Scholar 

  41. Tsokos GC, ed.Principles of Molecular Rheumatology. Totowa, NJ: Humana Press Inc; 2000:64-72.

    Google Scholar 

  42. Uzumcu A, Norget EE, Dindar A, et al. Loss of desmoplakin isoform 1 causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome.J Med Genet. 2006;43(2):e5.

    Article  PubMed  CAS  Google Scholar 

  43. Woodley DT, Chen M. The basement membrane zone. In: Freinkel RK, Woodley DT, eds.Biology of the Skin. Pearl River, NY: Parthenon Publishing Company; 2001:132-147.

    Google Scholar 

  44. Yancey KB, Allen DM. The biology of the basement membrane zone. In: Bolognia JL, Jorizzo JL, Rapini RP, eds.Dermatology. 2nd ed. St. Louis, MO: Mosby Elsevier; 2008:435-445.

    Google Scholar 

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Authors and Affiliations

  1. College of Medicine Private Practice, Assistant Clinical Professor of Dermatology University of Illinois at Chicago, West Dundee, IL, USA

    Sima Jain MD

  2. Orlando, FL, USA

    Sima Jain MD

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  1. Sima Jain MD
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Jain, S. (2011). Basic Science and Immunology. In: Dermatology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0525-3_1

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  • DOI: https://doi.org/10.1007/978-1-4419-0525-3_1

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  • Print ISBN: 978-1-4419-0524-6

  • Online ISBN: 978-1-4419-0525-3

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