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Glioblastoma pp 153–165Cite as

Adult Neural Stem Cells and Gliomagenesis

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Abstract

Gliomas are primary cancers of the brain and the most lethal cancers known to man. The recent discovery of stem cell and progenitor populations suggests that these cells residing in the postnatal brain may themselves serve as an origin of brain tumors. On the basis of CD133 expression, cancer stem cells and normal adult neural stem cells can be isolated by sorting and are shown to self-renew and exhibit multipotency. The identification of this cellular population has led to the suggestion that these cells represent the tumor-initiating fraction of human gliomas. Investigations of human neural stem cells and their potential for malignancy may finally identify a cell-of-origin for human gliomas. This, in turn, may facilitate better therapeutic targeting, identification of new markers for the progression of gliomas, earlier cancer detection, and development of new therapeutic agents.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California at San Francisco, 0112, M779, San Francisco, CA, 94143, USA

    Nader Sanai

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  1. Nader Sanai
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Correspondence to Nader Sanai .

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Editors and Affiliations

  1. Dept. Neurosciences, Medical University of South Carolina, Jonathan Lucas St. 96 , Charleston, 29425, U.S.A.

    Swapan K. Ray

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Sanai, N. (2010). Adult Neural Stem Cells and Gliomagenesis. In: Ray, S. (eds) Glioblastoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0410-2_7

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