Abstract
Because the uveal tract is a highly vascular structure with a low-flow microenvironment, it is well suited for seeding of circulating cancer cells. Numerous studies have shown that uveal metastases are the most common intraocular malignancies in adults. The most common primary cancers metastasizing to the uvea are breast and lung cancers. The most common symptom of uveal metastasis is blurred vision; however, patients may also present with vision loss, intraocular pain, scotoma, floaters, photopsias, and metamorphopsia. Treatment modalities include observation, external-beam radiation therapy, chemotherapy, plaque brachytherapy, transpupillary thermotherapy, and enucleation. For many patients, uveal metastasis is associated with advanced systemic disease, which portends a poor prognosis; however, early diagnosis and treatment of uveal metastasis can result in good visual outcomes and high rates of ocular salvage.
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Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit III. A clinicopathologic study of 28 cases metastatic to the orbit. Cancer 1976;38(3):1326–35.
Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit II. A clinicopathological study of 26 patients with carcinoma metastatic to the anterior segment of the eye. Arch Ophthalmol 1975;93(7):472–82.
Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol 1974;92(4):276–86.
Shields CL, Shields JA, Gross NE, Schwartz GP, Lally SE. Survey of 520 eyes with uveal metastases. Ophthalmology 1997;104(8):1265–76.
Amichetti M, Caffo O, Minatel E, et al. Ocular metastases from breast carcinoma: a multicentric retrospective study. Oncol Rep 2000;7(4):761–5.
Demirci H, Shields CL, Chao AN, Shields JA. Uveal metastasis from breast cancer in 264 patients. Am J Ophthalmol 2003;136(2):264–71.
Kurli M, Finger PT. The kidney, cancer, and the eye: current concepts. Surv Ophthalmol 2005;50(6):507–18.
Harbour JW, De Potter P, Shields CL, Shields JA. Uveal metastasis from carcinoid tumor. Clinical observations in nine cases. Ophthalmology 1994;101(6):1084–90.
Chang EL, Lo S. Diagnosis and management of central nervous system metastases from breast cancer. Oncologist 2003;8(5):398–410.
Kanthan GL, Jayamohan J, Yip D, Conway RM. Management of metastatic carcinoma of the uveal tract: an evidence-based analysis. Clin Exp Ophthalmol 2007;35(6):553–65.
Shields CL, Shields JA, De Potter P, et al. Plaque radiotherapy for the management of uveal metastasis. Arch Ophthalmol 1997;115(2):203–9.
Shields CL. Plaque radiotherapy for the management of uveal metastasis. Curr Opin Ophthalmol 1998;9(3):31–7.
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Camoriano, G.D., Gombos, D.S. (2010). Uveal Metastases from Solid Tumors. In: Esmaeli, B. (eds) Ophthalmic Oncology. M.D. Anderson Solid Tumor Oncology Series, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0374-7_16
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DOI: https://doi.org/10.1007/978-1-4419-0374-7_16
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