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Subtypes of HLA-B27: History and Implications in the Pathogenesis of Ankylosing Spondylitis

  • Chapter
Book cover Molecular Mechanisms of Spondyloarthropathies

Part of the book series: Advances in Experimental Medicine and Biology ((volume 649))

Abstract

HLA-B27 represents a family of 38 closely related cell surface proteins (encoded by the alleles HLA-B * 2701-39) called subtypes of HLA-B27, most of which have evolved from the ubiquitous HLA-B * 2705 (specifically the B * 27052 allele).1–25 HLA-B27 subtypes are largely characterized by nucleotide substitutions (mostly nonsynonymous) in exons 2 and 3 which encode α1 and α2 domains of the peptide binding groove respectively. Table 1 shows the description of sequences of HLA-B27 allele sequences. The subtypes could have arisen from B*2705 by point mutation (B*2703, B*2709, B*2704), gene conversion (B*2701, B*2702, B*2708) and reciprocal recombination (B*2707)26B*2706 could have arisen by interlocus gene conversion. Studies from different parts of the world reveal differences in the population distribution.

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Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center, 5656 Kelly St., Houston, TX, 77026, USA

    John D. Reveille

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  1. John D. Reveille
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  2. Rashmi M. Maganti
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  1. Hospital Universitario Central de Asturias, Oviedo, Spain

    Carlos López-Larrea PhD  & Roberto Díaz-Peña BSc  & 

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© 2009 Landes Bioscience and Springer Science+Business Media

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Reveille, J.D., Maganti, R.M. (2009). Subtypes of HLA-B27: History and Implications in the Pathogenesis of Ankylosing Spondylitis. In: López-Larrea, C., Díaz-Peña, R. (eds) Molecular Mechanisms of Spondyloarthropathies. Advances in Experimental Medicine and Biology, vol 649. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0298-6_12

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