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Surgical Management of Primary Osteosarcoma

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 152))

Abstract

Surgical strategies for the primary tumor for patients with extremity and pelvis osteosarcoma have evolved from the ablative to limb-sparing approaches over the past three decades. Favorable oncologic and functional outcomes with contemporary tissue-conserving techniques consistently observed in skeletally mature patients have prompted the application of similar approaches to a growing number of eligible skeletally immature patients.

In response to emerging long-term outcome data, current strategies have focused principally on refining the nature and scope of surgical resection to preserve uninvolved tissues, and on the adoption of novel biological and nonbiological skeletal and soft-tissue reconstruction methods to optimize function.

We focus on these clinical issues and discuss current efforts to advance the surgical management of the primary tumor and address the limitations of the definitive treatment of the primary tumor, including locally recurrent disease and complications of skeletal reconstructions.

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References

  1. Bacci G, et al. Influence of local recurrence on survival in patients with extremity osteosarcoma treated with neoadjuvant chemotherapy: the experience of a single institution with 44 patients. Cancer. 2006;106(12):2701-2706.

    Article  PubMed  Google Scholar 

  2. Mankin HJ, Mankin CJ, Simon MA. The hazards of the biopsy, revisited. Members of the musculoskeletal tumor society. J Bone Joint Surg Am. 1996;78(5):656-663.

    CAS  PubMed  Google Scholar 

  3. Iemsawatdikul K, et al. Seeding of osteosarcoma in the biopsy tract of a patient with multifocal osteosarcoma. Pediatr Radiol. 2005;35(7):717-721.

    Article  PubMed  Google Scholar 

  4. White VA, et al. Osteosarcoma and the role of fine-needle aspiration: a study of 51 cases. Cancer. 1988;62(6):1238-1246.

    Article  CAS  PubMed  Google Scholar 

  5. Ahrar K, et al. Percutaneous ultrasound-guided biopsy in the definitive diagnosis of osteosarcoma. J Vasc Interv Radiol. 2004;15(11):1329-1333.

    PubMed  Google Scholar 

  6. Puri A, et al. CT-guided percutaneous core needle biopsy in deep seated musculoskeletal lesions: a prospective study of 128 cases. Skeletal Radiol. 2006;35(3):138-143.

    Article  CAS  PubMed  Google Scholar 

  7. Kilpatrick SE, et al. The role of fine needle aspiration biopsy in the diagnosis and management of osteosarcoma. Pediatr Pathol Mol Med. 2001;20(3):175-187.

    CAS  PubMed  Google Scholar 

  8. Dodd LG, et al. Utility of fine-needle aspiration in the diagnosis of primary osteosarcoma. Diagn Cytopathol. 2002;27(6):350-353.

    Article  PubMed  Google Scholar 

  9. Domanski HA, Akerman M. Fine-needle aspiration of primary osteosarcoma: a cytological-histological study. Diagn Cytopathol. 2005;32(5):269-275.

    Article  PubMed  Google Scholar 

  10. Jelinek JS, et al. Diagnosis of primary bone tumors with image-guided percutaneous biopsy: experience with 110 tumors. Radiology. 2002;223(3):731-737.

    Article  PubMed  Google Scholar 

  11. Mitsuyoshi G, et al. Accurate diagnosis of musculoskeletal lesions by core needle biopsy. J Surg Oncol. 2006;94(1):21-27.

    Article  PubMed  Google Scholar 

  12. Carrino JA, et al. Magnetic resonance imaging-guided percutaneous biopsy of musculoskeletal lesions. J Bone Joint Surg Am. 2007;89(10):2179-2187.

    Article  PubMed  Google Scholar 

  13. Adams SC, et al. Consequences and prevention of inadvertent internal fixation of primary osseous sarcomas. Clin Orthop Relat Res. 2008;467:519-525.

    Article  PubMed  Google Scholar 

  14. Bacci G, et al. Predictive factors for local recurrence in osteosarcoma: 540 patients with extremity tumors followed for minimum 2.5 years after neoadjuvant chemotherapy. Acta Orthop Scand. 1998;69(3):230-236.

    Article  CAS  PubMed  Google Scholar 

  15. Bramer JA, et al. Do pathological fractures influence survival and local recurrence rate in bony sarcomas? Eur J Cancer. 2007;43(13):1944-1951.

    Article  CAS  PubMed  Google Scholar 

  16. Scully SP, et al. Pathologic fracture in osteosarcoma: prognostic importance and treatment implications. J Bone Joint Surg Am. 2002;84-A(1):49-57.

    PubMed  Google Scholar 

  17. Bacci G, et al. Nonmetastatic osteosarcoma of the extremity with pathologic fracture at presentation: local and systemic control by amputation or limb salvage after preoperative chemotherapy. Acta Orthop Scand. 2003;74(4):449-454.

    Article  PubMed  Google Scholar 

  18. van Kampen M, et al. Replacement of the hip in children with a tumor in the proximal part of the femur. J Bone Joint Surg Am. 2008;90(4):785-795.

    Article  PubMed  Google Scholar 

  19. Frink SJ, et al. Favorable long-term results of prosthetic arthroplasty of the knee for distal femur neoplasms. Clin Orthop Relat Res. 2005;438:65-70.

    Article  PubMed  Google Scholar 

  20. Belthur MV, et al. Extensible endoprostheses for bone tumors of the proximal femur in children. J Pediatr Orthop. 2003;23(2):230-235.

    Article  PubMed  Google Scholar 

  21. Gupta A, et al. Non-invasive distal femoral expandable endoprosthesis for limb-salvage surgery in paediatric tumours. J Bone Joint Surg Br. 2006;88(5):649-654.

    Article  CAS  PubMed  Google Scholar 

  22. Gupta A, et al. A knee-sparing distal femoral endoprosthesis using hydroxyapatite-coated extracortical plates. Preliminary results. J Bone Joint Surg Br. 2006;88(10):1367-1372.

    Article  CAS  PubMed  Google Scholar 

  23. Jeys LM, et al. Endoprosthetic reconstruction for the treatment of musculoskeletal tumors of the appendicular skeleton and pelvis. J Bone Joint Surg Am. 2008;90(6):1265-1271.

    Article  CAS  PubMed  Google Scholar 

  24. Weber KL, Lin PP, Yasko AW. Complex segmental elbow reconstruction after tumor resection. Clin Orthop Relat Res. 2003;415:31-44.

    Article  PubMed  Google Scholar 

  25. Biau D, et al. Survival of total knee replacement with a megaprosthesis after bone tumor resection. J Bone Joint Surg Am. 2006;88(6):1285-1293.

    Article  PubMed  Google Scholar 

  26. Myers GJ, et al. The long-term results of endoprosthetic replacement of the proximal tibia for bone tumours. J Bone Joint Surg Br. 2007;89(12):1632-1637.

    Article  CAS  PubMed  Google Scholar 

  27. Myers GJ, et al. Endoprosthetic replacement of the distal femur for bone tumours: long-term results. J Bone Joint Surg Br. 2007;89(4):521-526.

    Article  CAS  PubMed  Google Scholar 

  28. Chen, C.M., et al., Reconstruction of extremity long bone defects after sarcoma resection with vascularized fibula flaps: a 10-year review. Plast Reconstr Surg. 2007;119(3):915-924; discussion 925-926.

    Google Scholar 

  29. Friedrich JB, et al. Free vascularized fibular graft salvage of complications of long-bone allograft after tumor reconstruction. J Bone Joint Surg Am. 2008;90(1):93-100.

    Article  PubMed  Google Scholar 

  30. Moran SL, Shin AY, Bishop AT. The use of massive bone allograft with intramedullary free fibular flap for limb salvage in a pediatric and adolescent population. Plast Reconstr Surg. 2006;118(2):413-419.

    Article  CAS  PubMed  Google Scholar 

  31. Zaretski A, et al. Free fibula long bone reconstruction in orthopedic oncology: a surgical algorithm for reconstructive options. Plast Reconstr Surg. 2004;113(7):1989-2000.

    PubMed  Google Scholar 

  32. Bae DS, Waters PM, Gebhardt MC. Results of free vascularized fibula grafting for allograft nonunion after limb salvage surgery for malignant bone tumors. J Pediatr Orthop. 2006;26(6):809-814.

    PubMed  Google Scholar 

  33. Alman BA, De Bari A, Krajbich JI. Massive allografts in the treatment of osteosarcoma and Ewing sarcoma in children and adolescents. J Bone Joint Surg Am. 1995;77(1):54-64.

    CAS  PubMed  Google Scholar 

  34. Brigman BE, et al. Allografts about the knee in young patients with high-grade sarcoma. Clin Orthop Relat Res. 2004;421:232-239.

    Article  PubMed  Google Scholar 

  35. Kohler R, et al. Massive bone allografts in children. Int Orthop. 1990;14(3):249-253.

    Article  CAS  PubMed  Google Scholar 

  36. Muscolo DL, et al. Intercalary femur and tibia segmental allografts provide an acceptable alternative in reconstructing tumor resections. Clin Orthop Relat Res. 2004;426:97-102.

    Article  PubMed  Google Scholar 

  37. Muscolo DL, et al. Partial epiphyseal preservation and intercalary allograft reconstruction in high-grade metaphyseal osteosarcoma of the knee. J Bone Joint Surg Am. 2004;86-A(12):2686-2693.

    PubMed  Google Scholar 

  38. Deijkers RL, et al. Epidiaphyseal versus other intercalary allografts for tumors of the lower limb. Clin Orthop Relat Res. 2005;439:151-160.

    Article  CAS  PubMed  Google Scholar 

  39. Manfrini M, et al. Intraepiphyseal resection of the proximal tibia and its impact on lower limb growth. Clin Orthop Relat Res. 1999;358:111-119.

    Article  PubMed  Google Scholar 

  40. Muscolo DL, et al. Allograft reconstruction after sarcoma resection in children younger than 10 years old. Clin Orthop Relat Res. 2008;466(8):1856-1862.

    Article  PubMed  Google Scholar 

  41. Ramseier LE, et al. Allograft reconstruction for bone sarcoma of the tibia in the growing child. J Bone Joint Surg Br. 2006;88(1):95-99.

    Article  CAS  PubMed  Google Scholar 

  42. Chang DW, Weber KL. Use of a vascularized fibula bone flap and intercalary allograft for diaphyseal reconstruction after resection of primary extremity bone sarcomas. Plast Reconstr Surg. 2005;116(7):1918-1925.

    Article  CAS  PubMed  Google Scholar 

  43. Farid Y, et al. Endoprosthetic and allograft-prosthetic composite reconstruction of the proximal femur for bone neoplasms. Clin Orthop Relat Res. 2006;442:223-229.

    Article  PubMed  Google Scholar 

  44. Biau DJ, et al. Allograft-prosthesis composites after bone tumor resection at the proximal tibia. Clin Orthop Relat Res. 2007;456:211-217.

    Article  PubMed  Google Scholar 

  45. Erler K, et al. Reconstruction of defects following bone tumor resections by distraction osteogenesis. Arch Orthop Trauma Surg. 2005;125(3):177-183.

    Article  PubMed  Google Scholar 

  46. Dragan S, et al. The application of Ilizarov’s “bone segment transport” method in the treatment of tumors and tumor-like changes in bone. Ortop Traumatol Rehabil. 2002;4(4):441-451.

    CAS  PubMed  Google Scholar 

  47. Catagani MA, Ottaviani G. Ilizarov method to correct limb length discrepancy after limb-sparing hemipelvectomy. J Pediatr Orthop B. 2008;17(6):293-298.

    PubMed  Google Scholar 

  48. Ozaki T, Hillmann A, Winkelmann W. Treatment outcome of pelvic sarcomas in young children: orthopaedic and oncologic analysis. J Pediatr Orthop. 1998;18(3):350-355.

    Article  CAS  PubMed  Google Scholar 

  49. Canadell J, Forriol F, Cara JA. Removal of metaphyseal bone tumours with preservation of the epiphysis. Physeal distraction before excision. J Bone Joint Surg Br. 1994;76(1):127-132.

    CAS  PubMed  Google Scholar 

  50. Tsuchiya H, et al. Osteosarcoma around the knee. Intraepiphyseal excision and biological reconstruction with distraction osteogenesis. J Bone Joint Surg Br. 2002;84(8):1162-1166.

    Article  CAS  PubMed  Google Scholar 

  51. Fuchs B, et al. Osteosarcoma of the pelvis: outcome analysis of surgical treatment. Clin Orthop Relat Res. 2009;467(2):510-518.

    Google Scholar 

  52. Saab R, et al. Osteosarcoma of the pelvis in children and young adults: the St. Jude Children’s Research Hospital experience. Cancer. 2005;103(7):1468-1474.

    Article  PubMed  Google Scholar 

  53. Ozaki T, et al. High complication rate of reconstruction using Ilizarov bone transport method in patients with bone sarcomas. Arch Orthop Trauma Surg. 1998;118(3):136-139.

    Article  CAS  PubMed  Google Scholar 

  54. Kollender Y, et al. Internal hemipelvectomy for bone sarcomas in children and young adults: surgical considerations. Eur J Surg Oncol. 2000;26(4):398-404.

    Article  CAS  PubMed  Google Scholar 

  55. Hosalkar HS, Dormans JP. Surgical management of pelvic sarcoma in children. J Am Acad Orthop Surg. 2007;15(7):408-424.

    PubMed  Google Scholar 

  56. Hugate R Jr, Sim FH. Pelvic reconstruction techniques. Orthop Clin North Am. 2006;37(1):85-97.

    Article  PubMed  Google Scholar 

  57. Boriani S, et al. En bloc resections of bone tumors of the thoracolumbar spine. A preliminary report on 29 patients. Spine. 1996;21(16):1927-1931.

    Article  CAS  PubMed  Google Scholar 

  58. Liljenqvist U, et al. En bloc spondylectomy in malignant tumors of the spine. Eur Spine J. 2008;17(4):600-609.

    Article  PubMed  Google Scholar 

  59. Melcher I, et al. Primary malignant bone tumors and solitary metastases of the thoracolumbar spine: results by management with total en bloc spondylectomy. Eur Spine J. 2007;16(8):1193-1202.

    Article  PubMed  Google Scholar 

  60. Agarwal M, et al. Rotationplasty for bone tumors: is there still a role? Clin Orthop Relat Res. 2007;459:76-81.

    Article  PubMed  Google Scholar 

  61. Sawamura C, Hornicek FJ, Gebhardt MC. Complications and risk factors for failure of rotationplasty: review of 25 patients. Clin Orthop Relat Res. 2008;466(6):1302-1308.

    Article  PubMed  Google Scholar 

  62. Refaat Y, et al. Comparison of quality of life after amputation or limb salvage. Clin Orthop Relat Res. 2002;397:298-305.

    Article  PubMed  Google Scholar 

  63. Eiser C, et al. Quality of life implications as a consequence of surgery: limb salvage, primary and secondary amputation. Sarcoma. 2001;5(4):189-195.

    Article  CAS  PubMed  Google Scholar 

  64. Aksnes LH, et al. Limb-sparing surgery preserves more function than amputation: a Scandinavian sarcoma group study of 118 patients. J Bone Joint Surg Br. 2008;90(6):786-794.

    Article  CAS  PubMed  Google Scholar 

  65. Ginsberg JP, et al. A comparative analysis of functional outcomes in adolescents and young adults with lower-extremity bone sarcoma. Pediatr Blood Cancer. 2007;49(7):964-969.

    Article  PubMed  Google Scholar 

  66. Rodriguez-Galindo C, et al. Outcome after local recurrence of osteosarcoma: the St. Jude Children’s Research Hospital experience (1970–2000). Cancer. 2004;100(9):1928-1935.

    Article  PubMed  Google Scholar 

  67. Nathan SS, et al. Treatment algorithm for locally recurrent osteosarcoma based on local disease-free interval and the presence of lung metastasis. Cancer. 2006;107(7):1607-1616.

    Article  PubMed  Google Scholar 

  68. Weisstein, J.S., R.E. Goldsby, and R.J. O’Donnell, Oncologic approaches to pediatric limb preservation. J Am Acad Orthop Surg, 2005. 13(8): p. 544–54.

    Article  PubMed  Google Scholar 

  69. Neel, M.D., et al., Early multicenter experience with a noninvasive expandable prosthesis. Clin Orthop Relat Res, 2003(415): p. 72–81.

    Article  PubMed  Google Scholar 

  70. Futani, H., et al., Long-term follow-up after limb salvage in skeletally immature children with a primary malignant tumor of the distal end of the femur. J Bone Joint Surg Am, 2006. 88(3): p. 595–603.

    Article  PubMed  Google Scholar 

  71. Bacci G, et al., Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution. J Surg Oncol, 2007. 96(2): p. 118–23.

    Article  PubMed  Google Scholar 

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Correspondence to Alan W. Yasko .

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Yasko, A.W. (2009). Surgical Management of Primary Osteosarcoma. In: Jaffe, N., Bruland, O., Bielack, S. (eds) Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0284-9_6

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  • DOI: https://doi.org/10.1007/978-1-4419-0284-9_6

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