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Bridging the Gap Between Experimental Animals and Humans in Osteosarcoma

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Pediatric and Adolescent Osteosarcoma

Part of the book series: Cancer Treatment and Research ((CTAR,volume 152))

Abstract

Osteosarcoma has been reported in virtually all species of mammals (mouse, rat, rabbit, wolf, monkey, cat, dog, horse, ferret, cow, grizzly bear, camel, polar bear, and more), reptiles, fish, birds, and dinosaurs. The pet dog with osteosarcoma shares many similarities with the human condition, including histology, local and metastatic progression, and response to conventional treatment modalities.1 These similarities, coupled with the high prevalence of osteosarcoma in pet dogs, provide important opportunities to improve our understanding of osteosarcoma biology and therapy through the study of this naturally occurring model (Table 1)2.

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References

  1. Dernell WS, Ehrhart NP, Straw RC, et al. Tumors of the Skeletal System. In: Withrow SJ, Vail DM, eds. Withrow and MacEwen’s Small Animal Clinical Oncology. 4th ed. St Louis: Saunders Elsevier; 2007:540-582.

    Chapter  Google Scholar 

  2. Paoloni M, Khanna C. Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer. 2008;8:147-156.

    Article  CAS  PubMed  Google Scholar 

  3. Withrow SJ, Powers BE, Straw RC, et al. Comparative aspects of osteosarcoma: dog vs. man. Clin Orthop. 1991;270:159-167.

    PubMed  Google Scholar 

  4. Ru G, Terracini B, Glickman LT. Host related risk factors for canine osteosarcoma. Vet J. 1998;156:31-39.

    Article  CAS  PubMed  Google Scholar 

  5. Misdorp W, Hart AA. Some prognostic and epidemiological factors in canine osteosarcoma. J Natl Cancer Inst. 1979;62:537-545.

    CAS  PubMed  Google Scholar 

  6. Gellasch KL, Kalscheur VL, Clayton MK, et al. Fatigue microdamage in the radial predilection site for osteosarcoma in dogs. Am J Vet Res. 2002;63(6):896-899.

    Article  PubMed  Google Scholar 

  7. Stevenson S, Holm RB, Pohler OEM, et al. Fracture-associated sarcoma in the dog. J Am Vet Med Assoc. 1982;180:1189.

    CAS  PubMed  Google Scholar 

  8. Miller SC, Lloyd RD, Bruenger FW, et al. Comparisons of the skeletal locations of putative plutonium-induced osteosarcomas in humans with those in beagle dogs and with naturally occurring tumors in both species. Radiat Res. 2003;160(5):517-523.

    Article  CAS  PubMed  Google Scholar 

  9. White RG, Raabe OG, Culbertson MR, et al. Bone sarcoma characteristics and distribution in beagles injected with radium-226. Radiat Res. 1994;137(3):361-370.

    Article  CAS  PubMed  Google Scholar 

  10. McChesney-Gillette S, Gillette EL, Powers BE, et al. Radiation-induced osteosarcoma in dogs after external beam or intraoperative radiation therapy. Cancer Res. 1990;50:54-57.

    Google Scholar 

  11. Mayr B, Eschborn U, Loupal G, et al. Characterisation of complex karyotype changes in two canine bone tumours. Res Vet Sci. 1991;51(3):341-343.

    CAS  PubMed  Google Scholar 

  12. Thomas R, Scott A, Langford CF, et al. Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Res. 2005;15(12):1831-1837.

    Article  CAS  PubMed  Google Scholar 

  13. Campbell SE, Nasir L, Argyle DJ, et al. Cloning of canine IL-1ra, TNFR and TIMP-2. Vet Immunol Immunopathol. 2001;78(2):207-214.

    Article  CAS  PubMed  Google Scholar 

  14. Phillips JC, Stephenson B, Hauck M, et al. Heritability and segregation analysis of osteosarcoma in the Scottish deerhound. Genomics. 2007;90(3):354-363. Epub 2007 Jul 12.

    Article  CAS  PubMed  Google Scholar 

  15. Sagartz JE, Bodley WL, Gamblin RM, et al. p53 tumor suppressor protein overexpression in osteogenic tumors of dogs. Vet Pathol. 1996;33(2):213-221.

    Article  CAS  PubMed  Google Scholar 

  16. van Leeuwen IS, Cornelisse CJ, Misdorp W, et al. P53 gene mutations in osteosarcomas in the dog. Cancer Lett. 1997;111(1–2):173-178.

    PubMed  Google Scholar 

  17. Levine RA. Overexpression of the sis oncogene in a canine osteosarcoma cell line. Vet Pathol. 2002;39(3):411-412.

    Article  CAS  PubMed  Google Scholar 

  18. MacEwen EG, Pastor J, Kutzke J, Tsan R, et al. IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. J Cell Biochem. 2004;92(1):77-91.

    Article  CAS  PubMed  Google Scholar 

  19. Owen LN. Transplantation of canine osteosarcoma. Eur J Cancer. 1969;5:615-620.

    CAS  PubMed  Google Scholar 

  20. Wilson H, Huelsmeyer M, Chun R, et al. Isolation and characterisation of cancer stem cells from canine osteosarcoma. Vet J. 2008;175:69-75.

    Article  CAS  PubMed  Google Scholar 

  21. Barger AM, Fan TM, de Lorimier LP, et al. Expression of receptor activator of nuclear factor kappa-B ligand (RANKL) in neoplasms of dogs and cats. J Vet Intern Med. 2007;21(2):8.

    Google Scholar 

  22. Fan TM, de Lorimier LP, Charney SC. Urine N-telopeptide excretion in dogs with appendicular osteosarcoma. J Vet Intern Med. 2006;20(2):335-341.

    Article  PubMed  Google Scholar 

  23. Jankowski MK, Steyn PF, Lana SE, et al. Nuclear scanning with 99 m-Tc-HDP for the initial evaluation of osseous metastasis in canine osteosarcoma. Vet Comp Oncol. 2003;1:152-158.

    Article  CAS  PubMed  Google Scholar 

  24. Hillers KR, Dernell WS, Lafferty MHI, et al. Incidence and prognostic importance of lymph node metastases in dogs with appendicular osteosarcoma: 228 cases (1986–2003). J Am Vet Med Assoc. 2005;226(8):1364-1367.

    Article  PubMed  Google Scholar 

  25. Ehrhart N, Dernell WS, Hoffmann WE, et al. Prognostic importance of alkaline phosphatase activity in serum from dogs with appendicular osteosarcoma: 75 cases (1990–1996). J Am Vet Med Assoc. 1998;213:1002-1006.

    CAS  PubMed  Google Scholar 

  26. Thrall DE, Withrow SJ, Powers BE, et al. Radiotherapy prior to cortical allograft limb sparing in dogs with osteosarcoma: a dose response assay. Int J Rad Onc Biol Phys. 1990;18:1354-1357.

    Google Scholar 

  27. Farese JP, Milner R, Thompson MS, et al. Stereotactic radiosurgery for treatment of osteosarcomas involving the distal portions of the limbs in dogs. J Am Vet Med Assoc. 2004;225(10):1548, 1567-1572.

    Article  PubMed  Google Scholar 

  28. Straw RC, Withrow SJ. Limb-sparing surgery versus amputation for dogs with bone tumors. Vet Clin North Am. 1996;26:135-143.

    CAS  Google Scholar 

  29. Withrow SJ, Thrall DE, Straw RC, et al. Intra-arterial cisplatin with or without radiation in limbsparing for canine osteosarcoma. Cancer. 1993;71:2484-2490.

    Article  CAS  PubMed  Google Scholar 

  30. Powers BE, Withrow SJ, Thrall DE, et al. Percent tumor necrosis as a predictor of treatment response in canine osteosarcoma. Cancer. 1991;67:126-134.

    Article  CAS  PubMed  Google Scholar 

  31. Withrow SJ, Liptak J, Straw RC, et al. Biodegradable cisplatin polymer in limb-sparing surgery for canine osteosarcoma. Ann Surg Oncol. 2004;11(7):705-713.

    Article  PubMed  Google Scholar 

  32. Berg J, Weinstein MJ, Springfield DS, et al. Response of osteosarcoma in the dog to surgery and chemotherapy with doxorubicin. J Am Vet Med Assoc. 1995;206(10):1555-1560.

    CAS  PubMed  Google Scholar 

  33. Mauldin GN, Matus RE, Withrow SJ. Canine osteosarcoma treatment by amputation versus amputation and adjuvant chemotherapy using doxorubicin and cisplatin. J Vet Int Med. 1988;2:177-180.

    Article  CAS  Google Scholar 

  34. Kent MS, Strom A, Strom A, London CA, et al. Alternating carboplatin and doxorubicin as adjunctive chemotherapy to amputation or limb-sparing surgery in the treatment of appendicular osteosarcoma in dogs. J Vet Intern Med. 2004;18(4):540-544.

    Article  PubMed  Google Scholar 

  35. Withrow SJ, Straw RC, Brekke JH, et al. Slow release adjuvant cisplatin for the treatment of metastatic canine osteosarcoma. Eur J Musculoskel Res. 1995;4:105-110.

    CAS  Google Scholar 

  36. MacEwen EG, Kurzmann ID, Rosenthal RC. Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide. J Natl Cancer Inst. 1989;81:935-938.

    Article  CAS  PubMed  Google Scholar 

  37. Lascelles BDX, Dernell WS, Correa MT, et al. Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma. Annals of Surg Oncol. 2005;12(12):1073-1083.

    Article  Google Scholar 

  38. MacEwen EG, Kutzke J, Carew J, et al. c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells. Clin Exp Metastasis. 2003;20(5):421-430.

    Article  CAS  PubMed  Google Scholar 

  39. Lana SE, Ogilvie GK, Hansen RA, et al. Identification of matrix metalloproteinases in canine neoplastic tissue. Am J Vet Res. 2000;61(2):111-114.

    Article  CAS  PubMed  Google Scholar 

  40. Wergin MC, Kaser-Hotz B, Kaser-Hotz B. Plasma vascular endothelial growth factor (VEGF) measured in seventy dogs with spontaneously occurring tumours. In Vivo. 2004;18(1):15-19.

    CAS  PubMed  Google Scholar 

  41. Mullins MN, Lana SE, Dernell WS, et al. Cyclooxygenase-2 expression in canine appendicular osteosarcomas. J Vet Intern Med. 2004;18(6):859-865.

    Article  PubMed  Google Scholar 

  42. Khanna C, Wan X, Bose S, et al. Ezrin, a Membrane - Cytoskeleton Linker, is Necessary for Osteosarcoma Metastasis. Nat Medicine. 2004;10(2):182-186.

    Article  CAS  Google Scholar 

  43. Flint AF, U’Ren L, Legare ME, et al. Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. Vet Pathol. 2004;41(3):291-296.

    Article  CAS  PubMed  Google Scholar 

  44. O’Brien MG, Straw RC, Withrow SJ, et al. Resection of pulmonary metastases in canine osteosarcoma: 36 cases (1983–1992). Vet Surg. 1993;22:105-109.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Ft Collins, CO, 80523, USA

    Stephen J. Withrow

  2. Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA

    Chand Khanna

Authors
  1. Stephen J. Withrow
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  2. Chand Khanna
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Corresponding author

Correspondence to Stephen J. Withrow .

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Editors and Affiliations

  1. MD Anderson Cancer Center, University of Texas, Holcombe Blvd. 1515, Houston, 77030-4095, U.S.A.

    Norman Jaffe

  2. Dept. Medical Oncology, Norwegian Radium Hospital, Ullernschaussee 70, Oslo, 0310, Norway

    Oyvind S. Bruland

  3. Orthopädische Klinik, Olgahospital, Bismarckstraße 8, Stuttgart, 70176, Germany

    Stefan Bielack

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Withrow, S.J., Khanna, C. (2009). Bridging the Gap Between Experimental Animals and Humans in Osteosarcoma. In: Jaffe, N., Bruland, O., Bielack, S. (eds) Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0284-9_24

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  • DOI: https://doi.org/10.1007/978-1-4419-0284-9_24

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0283-2

  • Online ISBN: 978-1-4419-0284-9

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