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Molecular Imaging of the CNS: Drug Actions

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Imaging in CNS Drug Discovery and Development

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Abstract

Molecular imaging approaches play an important role in experimental and clinical neuroscience. Target-specific receptor ligands for positron emission tomography (PET) have been developed for the various neurotransmitter systems and a large number of CNS receptors. The PET readouts on ligand/drug biodistribution are complemented by functional/metabolic readouts provided by PET measurements of glucose utilization and blood flow or functional MRI assessment of the hemodynamic response. The tools are extensively used to characterize brain disorders such as psychiatric disorders or neurodegenerative processes and to evaluate therapeutic interventions.

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  1. Institute for Biomedical Engineering, University and ETH Zürich, HCI D426, Wolfgang-Pauli-Strasse 10, CH-8093, Zürich, Switzerland

    Markus Rudin

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  1. Thomas Mueggler
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    Lino R. Beccera

  3. Dept. Psychiatry, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom

    Edward Bullmore

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    Richard J. Hargreaves

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Mueggler, T., Rudin, M. (2010). Molecular Imaging of the CNS: Drug Actions. In: Borsook, D., Beccera, L., Bullmore, E., Hargreaves, R. (eds) Imaging in CNS Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0134-7_13

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