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Targeting of Apoptosis Signaling Pathways and Their Mediators for Cancer Therapy

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Pharmaceutical Perspectives of Cancer Therapeutics

Apoptosis, also known as programmed cell death, is essential for the regulation of development, the generation of the immune system, and is a central mechanism for maintenance of cellular homeostasis in eukaryotes. This phenomenon of cellular death was described for almost a century, and was named apoptosis only recently to differentiate naturally occurring cell death during development from the acute injury associated necrotic cell death [1]. The apoptosis processes function to maintain equilibrium between cell proliferation and death, while dysregulated apoptosis is involved in development and etiology of many pathological disorders. The acute pathological conditions such as stroke, heart attack, or liver failure as well as chronic neurodegenerative disorders are associated with increased apoptosis resulting in sudden or progressive death of the target tissues. The pathologies of auto-immune disorders and carcinogenesis, on the other hand, arise due in part to the loss or reduced rate of apoptosis.

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Acknowledgments

The authors gratefully acknowledge the grants support from the Department of Veterans Affairs Merit Review (AKR, AW) and the Susan G Komen Breast Cancer Foundation (AKR).

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Authors and Affiliations

  1. Karmanos Cancer Institute, Department of Internal Medicine,John D. Dingell VA Medical Center, Wayne State University, 4646 Detroit, MI 48201, USA

    Arun K. Rishi

  2. Karmanos Cancer Institute,Department of Surgery,John D. Dingell VA Medical Center, Wayne State University, Detroit, MI 48201, USA

    Xinbo Zhang & Anil Wali

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  1. Arun K. Rishi
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  2. Xinbo Zhang
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Correspondence to Arun K. Rishi .

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    Rishi, A.K., Zhang, X., Wali, A. (2009). Targeting of Apoptosis Signaling Pathways and Their Mediators for Cancer Therapy. In: Lu, Y., Mahato, R. (eds) Pharmaceutical Perspectives of Cancer Therapeutics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0131-6_5

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