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Animal Cell Technology: Basic & Applied Aspects pp 31–36Cite as

Effects of Sericin on Promoting Proliferation and Inhibiting Apoptosis of Mammalian Cells

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Part of the book series: Animal Cell Technology: Basic & Applied Aspects ((ANICELLTECH,volume 15))

Abstract

We have previously reported that sericin improves proliferation of all cells tested, as well suppressing cell death induced by heat stress, implying that sericin inhibits apoptosis. In sericin treatment, caspase7/3 activity, executioners for inducing apoptosis, was decreased, while caspase9 activity was not. In order to analyze the mode of action of sericin in detail, the gene expression pattern was studied by transcriptome analysis using cDNA microarrays. The expression of several genes was significantly upregulated, and others were downregulated by sericin treatment. Among the detected genes, some growth- and apoptosis-related genes may be involved in the proliferative and survival effects of sericin.

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References

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Acknowledgements

We thank Ms. Y. Tanaka and Ms. M. Sassa for their helpful advice.

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Authors and Affiliations

  1. Department of Applied Chemistry and Biotechnology, University of Fukui, 3-9-1, Bunkyo, Fukui, 910-8507, Japan

    Kana Yanagihara, Masao Miki & Satoshi Terada

  2. SEIREN Co. Ltd., 48-113-2, Yonozu, Mikuni-Cho, Sakai, Fukui, 913-0038, Japan

    Akiko Ogawa, Masahiro Sasaki & Hideyuki Yamada

Authors
  1. Kana Yanagihara
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  2. Masao Miki
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  3. Akiko Ogawa
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  4. Masahiro Sasaki
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  5. Hideyuki Yamada
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  6. Satoshi Terada
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Editor information

Editors and Affiliations

  1. Dept. Genetic Resources Technology, Kyushu University, Hakozaki 6-10-1, Fukuoka, 812-8581, Japan

    Sanetaka Shirahata

  2. Dept. Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, 606-8585, Japan

    Koji Ikura

  3. Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan

    Masaya Nagao

  4. Dept. Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, 606-8585, Japan

    Akira Ichikawa

  5. Fac. Agriculture, Kyushu University, Hakozaki, Fukuoka, 812-8581, Japan

    Kiichiro Teruya

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© 2008 Springer Science+Business Media B.V.

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Yanagihara, K., Miki, M., Ogawa, A., Sasaki, M., Yamada, H., Terada, S. (2008). Effects of Sericin on Promoting Proliferation and Inhibiting Apoptosis of Mammalian Cells. In: Shirahata, S., Ikura, K., Nagao, M., Ichikawa, A., Teruya, K. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 15. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9646-4_5

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