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Cancer Microenvironment and Therapeutic Implications pp 63–78Cite as

Cancer, Stem Cells and the Neoplastic Niche

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Abstract

Conventionally, cancer is treated as a homogenous mass of highly proliferative cells, with therapeutics designed to destroy rapidly dividing cells. However, not only are cancers heterogeneous, but also small subsets are endowed with the ability to initiate cancer formation and metastasis. The resistance of cancer initiating cells to current therapies may explain high relapse rates. Our inability to eradicate cancer may be due to misrecognition of the proper cancer target. Designing novel therapeutics for cancer eradication will require understanding specific pathways involved in cancer initiating cell self-renewal, differentiation and homing. Furthermore, targeting the distinctions of the cancer initiating cell microenvironment may be key to effective cancer therapies.

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  1. University of Florida, 1600 SW Archer Road, P.O. Box 100278, Gainesville, FL 32610-0278, USA

    Christopher R. Cogle

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  1. Legnano (Mi) and Radiotherapy / Hyperthermia Department, Policlinico di Monza, Via Amati, 111, 20052 Monza, Italy

    Gianfranco Baronzio

  2. Oncology Department, San Giuseppe Hospital, Via Giovanni Boccaccio, 18, 50053 Empoli, Italy

    Gianfranco Fiorentini

  3. University of Florida, 1600 SW. Archer Road, P.O.Box 100278, Gainesville, FL 32610-0278, USA

    Christopher R. Cogle

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Cogle, C.R. (2009). Cancer, Stem Cells and the Neoplastic Niche. In: Baronzio, G., Fiorentini, G., Cogle, C.R. (eds) Cancer Microenvironment and Therapeutic Implications. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9576-4_4

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