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The Use of Neurocognitive Endophenotypes in Large-Scale Family Genetic Studies of Schizophrenia

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The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes

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Abstract

Neurocognitive deficits are core features of schizophrenia and are among the most promising candidate endophenotypes for genetic studies of this disorder. The detection of gene-endophenotype associations requires large family cohort or case-control samples that are often only possible to collect through multisite collaborations, which presents considerable challenges for the use of endophenotypes. This chapter focuses on the rationale for using neurocognitive tasks of working memory, attention, and verbal declarative memory in large-scale, collaborative efforts to apply an endophenotype approach to schizophrenia. As an example, we describe the Consortium on the Genetics of Schizophrenia (COGS), a seven-site research network that investigates the genetic architecture of these neurocognitive and other candidate endopheno-types in families with schizophrenia. After providing a brief overview of the rigorous recruitment, data acquisition, and quality assurance procedures established by the COGS, we present recent results from this project that support utility of these procedures and the validity of neurocognitive endophenotypes. We conclude with a discussion of preliminary COGS findings that point toward specific candidate genes and future directions for this and other large-scale endophenotype studies of schizophrenia.

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Author information

Authors and Affiliations

  1. VA Greater Los Angeles Healthcare system & University of California, Los Angeles, CA, USA

    William P. Horan

  2. Department of Psychiatry, University of California, San Diego, CA, USA

    Tiffany A. Greenwood (Assistant Adjunct Professor of Psychiatry) & David L. Braff (Professor)

  3. Departments of Psychiatry, Neurology and Radiology, Director, Neuropsychiatry Section, University of Pennsylvania Medical Center, Philadelphia, PA, USA

    Raquel E. Gur (The Karl and Linda Rickels Professor and Vice Chair for Research Development)

  4. Semel Institute, University of California, Los Angeles, CA, USA

    Michael F. Green (Professor)

Authors
  1. William P. Horan
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  2. Tiffany A. Greenwood
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  3. David L. Braff
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  4. Raquel E. Gur
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  5. Michael F. Green
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Editor information

Editors and Affiliations

  1. Israel Institute of Technology, Haifa

    Michael S. Ritsner M.D., Ph.D. (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion) (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion)

  2. Sha'ar Menashe Mental Health Center, Hadera, Israel

    Michael S. Ritsner M.D., Ph.D. (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion) (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion)

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© 2009 Springer-Verlag Berlin Heidelberg

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Horan, W.P., Greenwood, T.A., Braff, D.L., Gur, R.E., Green, M.F. (2009). The Use of Neurocognitive Endophenotypes in Large-Scale Family Genetic Studies of Schizophrenia. In: Ritsner, M.S. (eds) The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9464-4_12

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