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B-Cell Repertoire Changes in Mouse Models of Aging

  • Chapter
Handbook on Immunosenescence

Abstract

Changes in the antibody repertoire are a well-established feature of immunosenescence. These reflect an aggregate of age-associated alterations in the generation, numbers, and proportions of B-cell subsets; as well as the homeostatic and selective processes governing them. A basic understanding of these relationships, coupled with integrated assessments of how they change with age, should reveal mechanisms underlying the immunosenescent phenotype. Mouse models provide powerful tools for these analyses, allowing controlled manipulation of key genetic, cellular, and microenvironmental factors. Here we summarize current understanding of how primary and antigen-experienced murine B-cell repertoires are established, as well as how they shift with age.

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  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, 19104-6082, Philadelphia, USA

    Jean L. Scholz, William J. Quinn III & Michael P. Cancro

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  1. Jean L. Scholz
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Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Scholz, J.L., Quinn, W.J., Cancro, M.P. (2009). B-Cell Repertoire Changes in Mouse Models of Aging. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_20

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