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Retinal and Choroidal Angiogenesis pp 241–257Cite as

The Regulation of Retinal Angiogenesis by Cyclooxygenase and the Prostanoids

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase and the formation of cyclooxygenase products, the prostanoids. Chronic use of NSAIDs has been associated with a reduced risk of colorectal cancer, which may be in part a consequence of reduced tumor-associated angiogenesis. These findings suggest that cyclooxygenase and the prostanoids may regulate angiogenesis. Several potentially blinding retinopathies have angiogenic components, and the putative roles of cyclooxgenase and the prostanoids in this context have been, and are currently, under investigation.

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  1. Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee

    Gary W. McCollum & John S. Penn

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    J.S. Penn

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© 2008 Springer Science+Business Media B.V.

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McCollum, G.W., Penn, J.S. (2008). The Regulation of Retinal Angiogenesis by Cyclooxygenase and the Prostanoids. In: Penn, J. (eds) Retinal and Choroidal Angiogenesis. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6780-8_13

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