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Oxidants, Antioxidants and Oxidative Stress

  • Chapter
Mitochondrial Medicine

Generation of reactive metabolites (RM) derived from oxygen and nitrogen is a consequence of life in the oxygen atmosphere. In the organism, RM represent a source of oxidative attacks to genetic material, proteins and lipids. RM overproduction, called oxidative stress, can modulate the redox state of the organism. RM interfere with signaling pathways which influence through gene expression cell growth, proliferation and apoptosis, as well as the immune response of the cell. The harmful effect of oxidants can be inhibited to a certain extent by enzymes with antioxidant properties and low-molecular weight endogenous and exogenous antioxidants.

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  1. Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Bratislava, Slovakia

    Zdenka Ďuračková Ph.D.

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  1. Zdenka Ďuračková Ph.D.
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    Anna Gvozdjáková Ph.D., D.Sc.

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Ďuračková, Z., Gvozdjáková, A. (2008). Oxidants, Antioxidants and Oxidative Stress. In: Gvozdjáková, A. (eds) Mitochondrial Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6714-3_2

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