We have previously demonstrated that sildenafil inhibits hypoxia-induced pulmonary vasoconstriction in healthy subjects. The aim of this study was to investigate the effects of the PDE5 inhibitor sildenafil on pulmonary hemodynamics in patients with high altitude pulmonary hypertension (HAPH). Twenty-two patients with HAPH were randomized by age and level of mean pulmonary arterial pressure (PAP) in 3 groups: a first group (n=9) treated with 25 mg of sildenafil 3 times a day; a second group (n=5) – received 100 mg of sildenafil 3 times a day; a third group (n=8) – treated with placebo. Pulmonary hemodynamics was measured by right heart catheterization at baseline and after 12 weeks of sildenafil therapy at, before and 1 hour after taking sildenafil or p
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Kojonazarov, B.K., Mirrakhimov, M.M., Morrell, N.W., Wilkins, M.R., Aldashev, A. (2007). Sildenafil And Hypoxic Pulmonary Hypertension. In: Aldashev, A., Naeije, R. (eds) Problems of High Altitude Medicine and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6300-8_9
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DOI: https://doi.org/10.1007/978-1-4020-6300-8_9
Publisher Name: Springer, Dordrecht
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