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The Peroxiredoxin Repair Proteins

  • Chapter
Book cover Peroxiredoxin Systems

Part of the book series: Subcellular Biochemistry ((SCBI,volume 44))

Abstract

Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry

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Authors and Affiliations

  1. Center for Structural Biology, Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157, USA

    Thomas J. Jönsson & W. Todd Lowther

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  1. Thomas J. Jönsson
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  1. MOLISA GmbH Magdeburg, Magdeburg, Germany

    Leopold Flohé

  2. University of Mainz, Mainz, Germany

    J. Robin Harris

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Jönsson, T.J., Lowther, W.T. (2007). The Peroxiredoxin Repair Proteins. In: Flohé, L., Harris, J.R. (eds) Peroxiredoxin Systems. Subcellular Biochemistry, vol 44. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6051-9_6

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