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Peroxiredoxin Systems pp 1–25Cite as

Introduction

History of the peroxiredoxins and topical perspectives

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 44))

Abstract

We have surveyed the early biochemical, structural and enzymatic studies on the peroxiredoxin family, within the broad context of the other chapters included within this book. Both the antioxidant defence and peroxide-linked cell signalling roles of the peroxiredoxins are introduced. The possible membrane-association of certain peroxiredoxins is assessed and the structural characterization of the peroxiredoxins by electron microscopy is given some emphasis here. The important contribution of X-ray crystallographic studies to the understanding of peroxiredoxin structure is given due attention. Finally, some medical perpectives are introduced, with emphasis upon the understanding of the microbial peroxiredoxins as possible future drug targets

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  1. MOLISA GmbH, Universitätsplatz 2, D-39106, Magdeburg, Germany

    Leopold Flohé

  2. Institute of Zoology, University of Mainz, D-55099, Mainz, Germany

    J. Robin Harris

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    Leopold Flohé

  2. University of Mainz, Mainz, Germany

    J. Robin Harris

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Flohé, L., Harris, J.R. (2007). Introduction. In: Flohé, L., Harris, J.R. (eds) Peroxiredoxin Systems. Subcellular Biochemistry, vol 44. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6051-9_1

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