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Polyunsaturated Fatty Acids and Prostate Cancer Metastasis

  • Chapter
Metastasis of Prostate Cancer

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 10))

Abstract

Polyunsaturated fatty acids have been demonstrated to have anticancer activities, on a number of tumor types including prostate cancer. There is evidence that these fatty acids may also influence the metastatic process of cancer. The anti-metastasis function is probably via the effects on more than one aspect of the metastatic process, including angiogenesis, cell adhesion and communication, matrix degradation and invasion, as well as the growth and death of prostate cancer cells. Clinical and epidemiological evidence has also pointed to the involvement of various fatty acids in the development and progression of prostate cancer. Some of the fatty acids have been evaluated for the possible anti-cancer effects in vivo and in limited clinical studies. This chapter summarises the recent development in scientific and clinical research into the possible impact of polyunsaturated fatty acids on prostate cancer.

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Authors and Affiliations

  1. Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK

    Wen G. Jiang

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  1. Wen G. Jiang
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  1. University of Arizona College of Medicine, and the Arizona Cancer Center, Tucson, AZ, U.S.A

    Richard J. Ablin

  2. University of Cardiff, U.K

    Malcolm D. Mason

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Jiang, W.G. (2008). Polyunsaturated Fatty Acids and Prostate Cancer Metastasis. In: Ablin, R.J., Mason, M.D. (eds) Metastasis of Prostate Cancer. Cancer Metastasis – Biology and Treatment, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5847-9_4

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