Skip to main content

Genetics, Life and Death

Genetics as providing a definition of life and death

  • Chapter
The Influence of Genetics on Contemporary Thinking

Part of the book series: Logic, Epistemology, and The Unity of Science ((LEUS,volume 6))

  • 601 Accesses

Abstract

There were two different and partially successive attempts of geneticists to associate genes with a definition of life. The first has its origin in the theoretical considerations elaborated at the end of the 19th century by biologists such as Hugo de Vries and August Weismann, looking for the molecular bases of biological processes and the mechanisms of their reproduction. It reached its most elaborate form in Hermann Muller’s contributions, and pervaded genetics during the first part of the century. The second was the paradoxical result of the program of gene reification endorsed by molecular biologists, which progressively ruined the previous ambitions. This gave way to a less naive vision of the relation between genes and the definition of life, focused no longer on the materialistic description of the gene, but on its power to control the adaptation of organisms to their environment.

It is interesting that the link between life and death that has remained a constant of philosophical investigations from Aristotle to Bichat has kept its place in this genetic approach to life. Definitions of life by both the molecular and population genetics have tried – with less success for the former – to justify the place of death in the economy of nature. Models, derived from genetics, are now used to describe the transmission of behaviors and beliefs between humans. They give genetic models a strong visibility in contemporary thinking

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adami C (1998) Introduction to artificial life. Springer-Verlag, New York

    Google Scholar 

  2. Allen GE (2000) The reception of Mendelism in the United States, 1900–1930. C. R. Acad. Sci. Paris, Sciences de la vie 323:1081–1088

    CAS  Google Scholar 

  3. Allen GE (2003) Mendel and modern genetics: the legacy for today. Endeavour 27:63–68

    Article  PubMed  Google Scholar 

  4. Buller DJ (2005) Adapting minds: evolutionary psychology and the persistent quest for human nature. MIT Press, Cambridge, MA

    Google Scholar 

  5. Burian RM, Gayon J (1999) The French school of genetics: from physiological and population genetics to regulatory molecular genetics. Annu Rev Genet 33:313–349

    Article  PubMed  CAS  Google Scholar 

  6. Canguilhem G (1968) La nouvelle connaissance de la vie: le concept et la vie inEtudes d’histoire et de philosophie des sciences, Vrin, Paris pp 335–364

    Google Scholar 

  7. Castle WE (1919) Piebald rats and the theory of genes. Proc Natl Acad Sci USA 5:126–130

    Article  PubMed  CAS  Google Scholar 

  8. Cohen HY, Miller C, Bitterman KJ et al. (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390–392

    Article  PubMed  CAS  Google Scholar 

  9. Dawkins R (1976) The selfish gene. Oxford University Press, New York

    Google Scholar 

  10. Gayon J (2004) La génétique est-elle encore une discipline? Med/Sci 20:248–253

    Google Scholar 

  11. Gonzalez BM (1923) Experimental studies on the duration of life: VIII. The influence upon duration of life of certain mutant genes of Drosophila melanogaster. Am Natur 62:289–325

    Article  Google Scholar 

  12. Guarente L (2003) Ageless quest: one scientist’s search for genes that prolong youth, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY

    Google Scholar 

  13. Jacob F (1970) La logique du vivant, Paris, Gallimard. Trans (1974) The logic of life, Princeton Scientific Library, Princeton, NJ

    Google Scholar 

  14. Jacob F (1981) Le jeu des possibles, Paris, Fayard. Trans (1982) The possible and the actual, University of Washington Press, Seattle, WA

    Google Scholar 

  15. Kamminga H (1988) Historical perspective: the problem of the origin of life in the context of developments in biology. Orig Life Evol Biosph 18:1–11

    Article  PubMed  CAS  Google Scholar 

  16. Kang K, Morange M (2001) Succès et limites de l’étude moléculaire de la mort cellulaire programmée. Annal. d’Hist. du Vivant 4:159–175

    Google Scholar 

  17. Kirkwood TBL,Rose MR (1991) Evolution of senescence: late survival sacrificed for reproduction. Phil Trans Roy Soc Lond $B$ 332:15–24

    Article  CAS  Google Scholar 

  18. Klarsfeld A, Revah F (2000) Biologie de la mort. Odile Jacob, Paris

    Google Scholar 

  19. Korfiatis KJ, Stamou GP (1994) Emergence of new fields in ecology: the case of life history studies. Hist Phil Life Sci 16:97–116

    CAS  Google Scholar 

  20. Kujoth GC, Hiona A, Pugh TD et al. (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309:481–484

    Article  PubMed  CAS  Google Scholar 

  21. Lewontin RC (1970) The units of selection. Annu Rev Ecol System 1:1–18

    Article  Google Scholar 

  22. Lockshin RA, Williams CM (1964) Programmed cell death – II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths. J Insect Physiol 10:643–649

    Article  CAS  Google Scholar 

  23. Lockshin RA, Williams CM (1965) Programmed cell death – I. Cytology of degeneration in the intersegmental muscles of the Pernyi silkmoth. J Insect Physiol 11:123–133

    Article  PubMed  CAS  Google Scholar 

  24. Machery E (2005) Why I stopped worrying about defining life ... and why you should as well, privileged communication

    Google Scholar 

  25. Manoli CM, Foss M, Villella A et al. (2005) Male-specific fruitless specifies the neural substrates of Drosophila courtship behavior. Nature 436:395–400

    PubMed  CAS  Google Scholar 

  26. Medawar PB (1952) An unsolved problem of biology. H. K. Lewis, London

    Google Scholar 

  27. Monod J (1970) Le hasard et la nécessité, Paris, Le Seuil. Trans (1972) Chance and necessity, Vintage books, New York

    Google Scholar 

  28. Morange M (2004) La génétique: une science aux caractéristiques très particulières. Bull Hist Epistém Sci Vie 11:235–247

    Google Scholar 

  29. Muller HJ (1927) Artificial transmutation of the gene. Science 66:84–87

    Article  PubMed  Google Scholar 

  30. Muller HJ (1929) The gene as the basis of life. Proceedings of the 4th international congress of plant science, Ithaca, I:879–921

    Google Scholar 

  31. Olby RC (1966) Origins of Mendelism. Constable, London

    Google Scholar 

  32. Olby RC (1974) The path to the double helix. Macmillan, London, Chap 9

    Google Scholar 

  33. Olby RC (1979) Mendel no Mendelian. Hist Sci 8:53–72

    Google Scholar 

  34. Pearl R, Parker SL, Gonzalez BM (1923) Experimental studies on the duration of life: VII.The Mendelian inheritance of duration of life in crosses of wild type and quintuple stocks of Drosophila melanogaster. Amer Nat 57:153–192

    Google Scholar 

  35. Pichot A (1999) Histoire de la notion de gene. Flammarion, Paris

    Google Scholar 

  36. Ravin AW (1977) The gene as catalyst; the gene as organism. Stud Hist Biol 1:1–45

    PubMed  CAS  Google Scholar 

  37. Rosenberg A (1994) Instrumental biology or the disunity of science. The University of Chicago Press, Chicago

    Google Scholar 

  38. Shostak S (1998) Death of life: the legacy of molecular biology. Macmillan, London

    Google Scholar 

  39. Troland LT (1917) Biological enigmas and the theory of enzyme action. Am Natur 51:321–350

    Article  Google Scholar 

  40. Williams GC (1957) Pleiotropy, natural selection, and the evolution of senescence. Evolution 11:398–411

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer

About this chapter

Cite this chapter

Morange, M. (2007). Genetics, Life and Death. In: Fagot-Largeault, A., Rahman, S., Torres, J.M. (eds) The Influence of Genetics on Contemporary Thinking. Logic, Epistemology, and The Unity of Science, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5664-2_4

Download citation

Publish with us

Policies and ethics