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Heat Shock Proteins: Potent Mediators of Inflammation and Immunity pp 309–320Cite as

The Pro- and Anti-Inflammatory Properties of the Stress Protein GP96

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Part of the book series: Heat Shock Proteins ((HESP,volume 1))

Abstract

Although the stress protein gp96 is commonly perceived as being a universal activator of antigen presenting cells and an inducer of tumour-specific immunity, at high doses it can inhibit the induction of tumour-specific immunity and experimental autoimmune disease by a mechanism which appears to involve immunoregulatory CD4+ T cells. Studies have shown that gp96 can also delay the rejection of allogeneic skin and cardiac transplants. This chapter summarises the work which has attributed pro- and anti-inflammatory properties to gp96 and highlights the potential mechanisms that might mediate the dual functionality of this molecule

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Authors and Affiliations

  1. Immunobiology Research Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, U.K.

    A. Graham Pockley & Munitta Muthana

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  1. A. Graham Pockley
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  2. Munitta Muthana
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Editors and Affiliations

  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology Scott & White Memorial Hospital and Clinic and The Texas A&M University System Health Science Center College of Medicine Temple, TX, U.S.A

    Alexzander A. A. Asea

  2. Department of Surgery, School of Medicine, University of California, San Diego, CA, U.S.A

    Antonio De Maio

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Pockley, A.G., Muthana, M. (2007). The Pro- and Anti-Inflammatory Properties of the Stress Protein GP96. In: Asea, A.A., Maio, A.D. (eds) Heat Shock Proteins: Potent Mediators of Inflammation and Immunity. Heat Shock Proteins, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5585-0_19

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