Abstract
The Finite-Difference Time-Domain (FDTD) modeling technique is applied to study the effect of the cell membrane thickness in optical immersion enhanced phase contrast microscope imaging. The FDTD approach is also applied for studying the implementation of the optical immersion technique for the visualization of single and multiple gold nanoparticles in biological cells.
Keywords
- Gold Nanoparticles
- Biological Cell
- Refractive Index Distribution
- Refractive Index Match
- Forward Scattered Light
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
P. N. Prasad, Bioimaging: principles and techniques, Chap. 7 in Introduction to biophotonics, John Wiley & Sons, New Jersey (2003), pp. 203–249.
V. V. Tuchin, Introduction to optical biomedical diagnostics, in Handbook of optical biomedical diagnostics, Valery V. Tuchin, Editor, SPIE Press, Bellingham, Washington (2002), pp. 1–25.
F. M. Kahnert, Numerical methods in electromagnetic scattering theory, Journal of Quantitative Spectroscopy and Radiative Transfer 73 (2003), pp. 775–824.
A. Dunn, C. Smithpeter, A. J. Welch and R. Richards-Kortum, Light scattering from cells, OSA Technical Digest – Biomedical Optical Spectroscopy and Diagnostics, Washington, Optical Society of America (1996), pp. 50–52.
A. Dunn, and R. Richards-Kortum, Three-dimensional computation of light scattering from cells, IEEE Journal of Selected Topics in Quantum Electronics 2 (1996), pp. 898–894.
A. Dunn, Light Scattering Properties of Cells, PhD Dissertation, Biomedical Engineering, University of Texas at Austin, Austin TX (1997): http://www.nmr.mgh.harvard.edu/7Eadunn/papers/dissertation/index.html
A. Dunn, C. Smithpeter, A. J. Welch and R. Richards-Kortum, Finite-difference time domain simulation of light scattering from single cells, Journal of Biomedical Optics 2 (1997), pp. 262–266.
R. Drezek, A. Dunn and R. Richards-Kortum, Light scattering from cells: finitedifference time-domain simulations and goniometric measurements, Applied Optics 38 (1999), pp. 3651–3661.
R. Drezek, A. Dunn and R. Richards-Kortum, A pulsed finite-difference time-domain (FDTD) method for calculating light scattering from biological cells over broad wavelength ranges, Optics Express 6 (2000), pp. 147–157.
A. V. Myakov, A. M. Sergeev, L.S. Dolin, R. Richards-Kortum, Finite-dfference time domain simulation of light scattering from multiple cells, Technical Digest, Conference on Lasers and Electro-Optics (CLEO) (1999), pp. 81–82.
T. Tanifuji, N. Chiba and M. Hijikata, FDTD (finite difference time domain) analysis of optical pulse responses in biological tissues for spectroscopic diffused optical tomography, Technical Digest, The 4th Pacific RIM Conference on Lasers and Electro-Optics 1 (2001), pp. I-376–I-377.
T. Tanifuji and M. Hijikata, Finite difference time domain (FDTD) analysis of optical pulse responses in biological tissues for spectroscopic diffused optical tomography, IEEE Transactions on medical imaging 21, No. 2, (2002), pp. 181–184.
R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, R. R. Richards-Kortum, Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture, Journal of Biomedical Optics 8 (2003), pp. 7–16.
D. Arifler, M. Guillaud, A. Carraro, A. Malpica, M. Follen, R. Richards-Kortum, Light scattering from normal and dysplastic cervical cells at different epithelial depths: finitedifference time domain modeling with a perfectly matched layer boundary condition, Journal of Biomedical Optics 8 (2003), pp. 484–494.
S. Tanev, W. Sun, R. Zhang and A. Ridsdale, The FDTD approach applied to light scattering from single biological cells, Proceedings of SPIE, Vol. 5474, Saratov Fall Meeting 2003, Optical Technologies in Biophysics and Medicine V (2004), pp. 162–168.
S. Tanev, W. Sun, R. Zhang and A. Ridsdale, Simulation tools solve light-scattering problems from biological cells, Laser Focus World (January 2004), pp. 67–70.
S. Tanev, W. Sun, N. Loeb, P. Paddon and V. V. Tuchin, The Finite-Difference Time-Domain Method in the Biosciences: Modelling of Light Scattering by Biological Cells in Absorptive and Controlled Extra-cellular Media, in Advances in Biophotonics, Ed. B. C. Wilson, V. V. Tuchin and S. Tanev, NATO Science Series I, vol. 369, IOS Press, Amsterdam, 2005, pp. 45–78.
G. Mie, Beigrade zur optic truber medien, speziell kolloidaler metallsungen, Ann. Phys. (Leipzig) 25 (1908), pp. 377–455.
W. Sun, N. G. Loeb and Q. Fu, Light scattering by coated sphere immersed in absorbing medium: a comparison between the FDTD and analytic solutions, Journal of Quantitative Spectroscopy & Radiative Transfer 83 (2004), pp. 483–492.
R. Barer, K. F. A. Ross, and S. Tkaczyk, Refractometry of living cells, Nature 171 (1953), pp. 720–724.
R. Barer and S. Joseph, Refractometry of living cells, Q. J. Microsc. Sci. 95 (1954), pp. 399–406.
B. A. Fikhman, Microbiological Refractometry, Medicine, Moscow (1967).
H. Liu, B. Beauvoit, M. Kimura, and B. Chance, Dependence of tissue optical properties on solute – induced changes in refractive index and osmolarity, Journal of Biomedical Optics 1 (1996), pp. 200–211.
V. V. Tuchin, I. L. Maksimova, D. A. Zimnyakov, I. L. Kon, A. H. Mavlutov, and A. A. Mishin, Light propagation in tissues with controlled optical properties, Journal of Biomedical Optics 2 (1997), pp. 401–417.
D. A. Zimnyakov, V. V. Tuchin, and A. A. Mishin, Spatial speckle correlometry in applications to tissue structure monitoring, Applied Optics 36 (1997), pp. 5594–5607.
G. Vargas, E. K. Chan, J. K. Barton, H. G. Rylander III, and A. J. Welch, Use of an agent to reduce scattering in skin, Laser Surg. Med. 24 (1999), pp. 133–141.
V. V. Tuchin, Control of tissue and blood optical properties, in Advances in Biophotonics, Ed. B. C. Wilson, V. V. Tuchin and S. Tanev, NATO Science Series I, vol. 369, IOS Press, Amsterdam, 2005, pp. 79–122.
W. Sun, N. G. Loeb, S. Tanev, and G. Videen, Finite-difference time-domain solution of light scattering by an infinite dielectric column immersed in an absorbing medium, Applied Optics 44, No. 10 (2005), pp. 1977–1983.
A. Taflove and S. Hagness, Computational Electrodynamics: The Finite-Difference Time Domain Method, Artech House, Boston, 2000.
The FDTD Solutions™ was developed by Lumerical Solutions Inc., Vancouver, BC, Canada: www.lumerical.com
K. Sokolov, M. Follen, J. Aaron, I. Pavlova, A. Malpica, R. Lotan and R. Richards-Kortum, Real-time vital optical imaging of precancer using anti-epidermal growth
I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer, Nano Letters 5, No. 5 (2005), pp. 829–834.
N. G. Khlebtsov, A. G. Melnikov, L. A. Dykman and V. A. Bogatyrev, Optical properties and biomedical applications of nanostructures based on gold and silver bioconjugates, in Photopolarimetry in Remote Sensing, G. Videen, Ya. S. Yatskiv and M. I. Mishchenko (Eds.), NATO Science Series, II. Mathematics, Physics, and Chemistry, vol. 161, Kluwer, Dordrecht, 2004, pp. 265–308.
Vladimir P. Zharov, Jin-Woo Kim, David T. Curiel, Maaike Everts, Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy, Review article in Nanomedicine: Nanotechnology, Biology, and Medicine 1 (2005), pp. 326–345.
Vladimir P. Zharov, Kelly E. Mercer,y Elena N. Galitovskaya, and Mark S. Smeltzer, Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles, Biophysical Journal 90 (2006), pp. 619–627.
P. B. Johnson and R. W. Christy, Optical constants of noble metals, Physical Review B6 (1972), pp. 4370–4379.
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TANEV, S., TUCHIN, V.V., PADDON, P. (2006). FINITE-DIFFERENCE TIME-DOMAIN MODELING OF LIGHT SCATTERING FROM BIOLOGICAL CELLS CONTAINING GOLD NANOPARTICLES. In: Dubowski, J.J., Tanev, S. (eds) Photon-based Nanoscience and Nanobiotechnology. NATO Science Series, vol 239. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5523-2_5
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DOI: https://doi.org/10.1007/978-1-4020-5523-2_5
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