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Cell Adhesion and Cytoskeletal Molecules in Metastasis pp 141–162Cite as

CELL ADHESION-MEDIATED RADIATION RESISTANCE: THE ROLE OF INTEGRINS AND INTEGRIN PROXIMAL PROTEIN

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Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 9))

Abstract

Existent or acquired resistance of tumor cells against genotoxic agents such as ionizing radiation or cytotoxic drugs is a widespread and clinically highly relevant phenomenon. Identifying cell-extracellular matrix interactions as critical, survival-improving factors within cellular resistance for normal and tumor cells has promoted intense research in this field. This chapter summarizes current and emerging data on how the molecular players such as integrins and intracellular protein kinases such as integrin-linked kinase and focal adhesion kinase coordinate signaling events for the cellular survival and growth response in DNA-damaged cells adherent to matrix proteins. Uncovering the molecular mechanisms may help to dissect central survival regulators in normal versus tumor tissue, which would provide the necessary knowledge for developing further innovative molecular-targeted anticancer strategies.

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Authors and Affiliations

  1. OcoRay-Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany

    Nils Cordes

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  1. Nils Cordes
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  1. University of Arizona, Tucson, AZ, U.S.A.

    Anne E. Cress

  2. University of Arizona, Tucson, AZ, U.S.A.

    Raymond B. Nagle

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© 2006 Springer

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Cordes, N. (2006). CELL ADHESION-MEDIATED RADIATION RESISTANCE: THE ROLE OF INTEGRINS AND INTEGRIN PROXIMAL PROTEIN. In: Cress, A.E., Nagle, R.B. (eds) Cell Adhesion and Cytoskeletal Molecules in Metastasis. Cancer Metastasis – Biology and Treatment, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5129-6_8

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