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CYTOKERATIN 6 EXPRESSION IN PROSTATE STEM CELLS

  • Chapter
Cell Adhesion and Cytoskeletal Molecules in Metastasis

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 9))

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Abstract

The simplified epithelium of the human prostate gland is representative of a slowly growing but morphologically dynamic tissue. The normal prostate gland contains, in part, the persistent basal cell population and the putative stem cells. It has been postulated by others that the transformation of normal glandular structures into cancer glands and subsequent tumor progression may involve aberrant regulation of the stem cell population. In this chapter, the induction of cytokeratin 6 expression is postulated to participate in the transition of a stem cell from its specialized niche within the basal cell population into a differentiated state. The basic morphological features of the normal prostate gland are reviewed and the molecular features of the prostate stem cells are discussed. Data is presented to illustrate the defining features of a new epithelial phenotype in the prostate gland, containing both cytokeratin 6 expression and the capability to differentiate and reach from the basal cell layer to the luminal surface of the gland. These results underscore the plasticity of the epithelial cell layers and the potential for cytokeratin 6 to serve as an efficient marker for an important subset of the basal cell population. Further investigation will be required in animal models to determine the essential nature of the cytokeratin 6 expression for the normal development of the prostate gland.

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Authors and Affiliations

  1. Department of Pathology, Southern Arizona Veterans Affairs Health Care System, Tucson, AZ, USA

    Monika Schmelz & Anil Prasad

  2. Department of Pathology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA

    Monika Schmelz & Anil Prasad

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  1. Monika Schmelz
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  1. University of Arizona, Tucson, AZ, U.S.A.

    Anne E. Cress

  2. University of Arizona, Tucson, AZ, U.S.A.

    Raymond B. Nagle

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Schmelz, M., Prasad, A. (2006). CYTOKERATIN 6 EXPRESSION IN PROSTATE STEM CELLS. In: Cress, A.E., Nagle, R.B. (eds) Cell Adhesion and Cytoskeletal Molecules in Metastasis. Cancer Metastasis – Biology and Treatment, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5129-6_6

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