Abstract
The management of non-muscle-invasive bladder cancer (NMIBC) in the elderly is complex and must be tailored to the individual needs and the physical capacity of this particular group of patients, taking into account the frailty status and life expectancy. On one hand, treatments that may be required might further stress an already vulnerable organism, carrying the risk of being more harmful to the patient than the disease itself. On the other hand, a surprisingly high cancer-specific mortality has been shown even in this old age group, which makes active treatment, and not only palliative approach, advised in fit categories. The issue of reduced efficacy of intravesical therapy, such as BCG, with advancing age further complicates the picture. More radical treatment such as early cystectomy has been shown to be feasible also in octogenarians, keeping in mind that the risk of intraoperative death or major complications becomes relevant in advanced age groups. In this respect, device-assisted administration of intravesical therapies will play an increasing role in the future. Unfortunately, up-to-date, no specific guidelines exist to guide the physician choosing the optimum management of these older patients, who too often end up receiving substandard care.
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References
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
Siegel R, Ward E, Brawley O, Jemal A. The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61:212–36.
Shariat SF, Milowsky M, Droller MJ. Bladder cancer in the elderly. Urol Oncol. 2009;27:653–67.
Prout Jr GR, Wesley MN, Yancik R, Ries LA, Havlik RJ, Edwards BK. Age and comorbidity impact surgical therapy in older bladder carcinoma patients: a population-based study. Cancer. 2005;104(8):1638–47.
United Nations Department of Economic and Social Affairs/Population Division. World Population to 2300. www.unpopulation.org
Shariat SF, Sfakianos JP, Droller MJ, Karakiewicz PI, Meryn S, Bochner BH. The effect of age and gender on bladder cancer: a critical review of the literature. BJU Int. 2009;105:300–8.
Froehner M, Brausi MA, Herr HW, Muto G, Studer UE. Complications following radical cystectomy for bladder cancer in the elderly. Eur Urol. 2009;56:443–54.
Crews DE, Zavotka S. Aging, disability, and frailty: implications for universal design. J Physiol Anthropol. 2006;25:113–8.
Fried LP, Tanged CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA. Frailty in older adults: evidence for a phenotype. J Gerontol. 2001;56A(3):M146–56.
Taylor III JA, Kuchel GA. Bladder cancer in the elderly: clinical outcomes, basic mechanisms, and future research direction. Nat Clin Pract Urol. 2009;6(3):135–44.
Messing EM. Urothelial tumors of the bladder (chapter 75). In: Campbell-Walsh urology. 9th ed. Philadelphia: Saunders Elsevier; 2008. p. 2407–746.
Schultzel M, Saltzstein SL, Downs TM, Shimasaki S, Sanders C, Sadler GR. Late age (85 years or older) peak incidence of bladder cancer. J Urol. 2008;179:1302–6.
Shi B, Zhang K, Zhang J, Chen J, Zhang N, Xu Z. Relationship between patient age and superficial transitional cell carcinoma characteristics. Urology. 2008;71:1186–90.
Scosyrev E, Wu G, Golijanin D, Messing E. Non-bladder cancer mortality in patients with urothelial cancer of the bladder. Urol Oncol. 2011 May 6. [Epub ahead of print].
Kohjimoto Y, Iba A, Shintani Y, Inagaki T, Uekado Y, Hara I. Impact of patient age on outcome following bladder-preserving treatment for non-muscle-invasive bladder cancer. World J Urol. 2010;28:425–30.
Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Böhle A, Palou-Redorta J, Rouprêt M. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update. Eur Urol. 2011;59(6):997–1008.
Blandy JP, Notley RG, Reynard JM. Complications occurring during transurethral resection (chapter 10). In: Transurethral resection. 5th ed. London: Taylor & Francis; 2005. p. 182–6.
Heiner JG, Terris MK. Effect of advanced age on the development of complications from intravesical bacillus Calmette-Guérin therapy. Urol Oncol. 2008;26:137–40.
Gofrit ON, Pode D, Lazar A, Katz R, Shapiro A. Watchful waiting policy in recurrent TaG1 bladder tumours. Eur Urol. 2006;49:303–7.
Oosterlinck W, Bono AV, Mack D, et al. Frequency of positive biopsies after visual disappearance of superficial bladder cancer marker lesions. Eur Urol. 2001;40:515–7.
Soloway MS, Bruck DS, Kim SS. Expectant management of small, recurrent, noninvasive papillary bladder tumours. J Urol. 2003;170:438–41.
Gontero P, Bohle A, Malmstrom PU, O’Donnel MA, Oderda M, Sylvester R, Witjes F. The role of bacillus Calmette-Guérin in the treatment of non-muscle-invasive bladder cancer. Eur Urol. 2010;57:410–29.
Huncharek M, Kupelnick B. Impact of intravesical chemotherapy versus BCG immunotherapy on recurrence of superficial transitional cell carcinoma of the bladder: metaanalytic reevaluation. Am J Clin Oncol. 2003;26(4):402–7.
Sylvester R, Van der Meijden A, Lamm D. Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials. J Urol. 2002;168:1964–70.
DeVeale B, Brummel T, Seroude L. Immunity and aging: the enemy within? Aging Cell. 2004;3:195–208.
Joudi FN, Smith BJ, O’Donnell MA. Final results from a national multicenter phase II trial of combination bacillus Calmette-Guérin plus interferon α-2B for reducing recurrence of superficial bladder cancer. Urol Oncol. 2006;24:344–8.
Herr HW. Age and outcome of superficial bladder cancer treated with bacilli Calmette-Guérin therapy. Urology. 2007;70:65–8.
Yuge K, Kikuchi E, Matsumoto K, Takeda T, Miyajima A, Oya M. Could patient age influence tumor recurrence rate in non-muscle-invasive bladder cancer patients treated with BCG immunotherapy? Jpn J Clin Oncol. 2011;41(4):565–70.
Margel D, Alkhateeb SS, Finelli A, Fleshner N. Diminished efficacy of bacilli Calmette-Guérin among elderly patients with nonmuscle invasive bladder cancer. Urology. 2011;78:848–54.
Palou J, Angerri O, Segarra J, Caparrós J, Guirado L, Diaz JM, Salvador-Bayarri J, Villavicencio-Mavrich H. Intravesical bacillus Calmette-Guèrin for the treatment of superficial bladder cancer in renal transplant patients. Transplantation. 2003;76(10):1514–6.
Yossepowitch O, Eggener S, Bochner B, Donat M, Herr H, Dalbagni G. Safety and efficacy of intravesical bacillus Calmette-Guérin instillations in steroid treated and immunocompromised patients. J Urol. 2006;176:482–5.
Palou J, Solsona E, Angulo J, Fernà ndez JM, Unda M, Martinez Pineiro L. Retrospective study of different options in the management of non-muscle invasive bladder cancer T1G3: maintenance BCG is here to stay. Eur Urol Suppl. 2011;10(2):149.
Kulkarni GS, Alibhai SMH, Finelli A, Fleshner NE, Jewett MAS, Lopushinsky AM. Cost-effectiveness analysis of immediate radical cystectomy versus intravesical bacillus Calmette-Guerin therapy for high-risk, high-grade (T1G3) bladder cancer. Cancer. 2009;115:5450–9.
Colombo R, Salonia A, Leib Z, Pavone-Macaluso M, Engelstein D. Long-term outcomes of a randomized controlled trial comparing thermochemotherapy with mitomycin-C alone as adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC). BJU. 2010;107:912–8.
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Oderda, M., Gontero, P., Joniau, S. (2013). Management of Superficial Bladder Cancer in Elderly Patients. In: Droz, JP., Audisio, R. (eds) Management of Urological Cancers in Older People. Management of Cancer in Older People, vol 1. Springer, London. https://doi.org/10.1007/978-0-85729-999-4_16
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DOI: https://doi.org/10.1007/978-0-85729-999-4_16
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