Skip to main content

Management of Superficial Bladder Cancer in Elderly Patients

  • Chapter
  • First Online:
Management of Urological Cancers in Older People

Abstract

The management of non-muscle-invasive bladder cancer (NMIBC) in the elderly is complex and must be tailored to the individual needs and the physical capacity of this particular group of patients, taking into account the frailty status and life expectancy. On one hand, treatments that may be required might further stress an already vulnerable organism, carrying the risk of being more harmful to the patient than the disease itself. On the other hand, a surprisingly high cancer-specific mortality has been shown even in this old age group, which makes active treatment, and not only palliative approach, advised in fit categories. The issue of reduced efficacy of intravesical therapy, such as BCG, with advancing age further complicates the picture. More radical treatment such as early cystectomy has been shown to be feasible also in octogenarians, keeping in mind that the risk of intraoperative death or major complications becomes relevant in advanced age groups. In this respect, device-assisted administration of intravesical therapies will play an increasing role in the future. Unfortunately, up-to-date, no specific guidelines exist to guide the physician choosing the optimum management of these older patients, who too often end up receiving substandard care.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 229.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.

    Article  PubMed  Google Scholar 

  2. Siegel R, Ward E, Brawley O, Jemal A. The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61:212–36.

    Article  PubMed  Google Scholar 

  3. Shariat SF, Milowsky M, Droller MJ. Bladder cancer in the elderly. Urol Oncol. 2009;27:653–67.

    Article  PubMed  Google Scholar 

  4. Prout Jr GR, Wesley MN, Yancik R, Ries LA, Havlik RJ, Edwards BK. Age and comorbidity impact surgical therapy in older bladder carcinoma patients: a population-based study. Cancer. 2005;104(8):1638–47.

    Article  PubMed  Google Scholar 

  5. United Nations Department of Economic and Social Affairs/Population Division. World Population to 2300. www.unpopulation.org

  6. Shariat SF, Sfakianos JP, Droller MJ, Karakiewicz PI, Meryn S, Bochner BH. The effect of age and gender on bladder cancer: a critical review of the literature. BJU Int. 2009;105:300–8.

    Article  PubMed  Google Scholar 

  7. Froehner M, Brausi MA, Herr HW, Muto G, Studer UE. Complications following radical cystectomy for bladder cancer in the elderly. Eur Urol. 2009;56:443–54.

    Article  PubMed  Google Scholar 

  8. Crews DE, Zavotka S. Aging, disability, and frailty: implications for universal design. J Physiol Anthropol. 2006;25:113–8.

    Article  PubMed  Google Scholar 

  9. Fried LP, Tanged CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA. Frailty in older adults: evidence for a phenotype. J Gerontol. 2001;56A(3):M146–56.

    Google Scholar 

  10. Taylor III JA, Kuchel GA. Bladder cancer in the elderly: clinical outcomes, basic mechanisms, and future research direction. Nat Clin Pract Urol. 2009;6(3):135–44.

    Article  PubMed  Google Scholar 

  11. Messing EM. Urothelial tumors of the bladder (chapter 75). In: Campbell-Walsh urology. 9th ed. Philadelphia: Saunders Elsevier; 2008. p. 2407–746.

    Google Scholar 

  12. Schultzel M, Saltzstein SL, Downs TM, Shimasaki S, Sanders C, Sadler GR. Late age (85 years or older) peak incidence of bladder cancer. J Urol. 2008;179:1302–6.

    Article  PubMed  Google Scholar 

  13. Shi B, Zhang K, Zhang J, Chen J, Zhang N, Xu Z. Relationship between patient age and superficial transitional cell carcinoma characteristics. Urology. 2008;71:1186–90.

    Article  PubMed  Google Scholar 

  14. Scosyrev E, Wu G, Golijanin D, Messing E. Non-bladder cancer mortality in patients with urothelial cancer of the bladder. Urol Oncol. 2011 May 6. [Epub ahead of print].

    Google Scholar 

  15. Kohjimoto Y, Iba A, Shintani Y, Inagaki T, Uekado Y, Hara I. Impact of patient age on outcome following bladder-preserving treatment for non-muscle-invasive bladder cancer. World J Urol. 2010;28:425–30.

    Article  PubMed  Google Scholar 

  16. Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Böhle A, Palou-Redorta J, Rouprêt M. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update. Eur Urol. 2011;59(6):997–1008.

    Article  PubMed  Google Scholar 

  17. Blandy JP, Notley RG, Reynard JM. Complications occurring during transurethral resection (chapter 10). In: Transurethral resection. 5th ed. London: Taylor & Francis; 2005. p. 182–6.

    Google Scholar 

  18. Heiner JG, Terris MK. Effect of advanced age on the development of complications from intravesical bacillus Calmette-Guérin therapy. Urol Oncol. 2008;26:137–40.

    Article  PubMed  Google Scholar 

  19. Gofrit ON, Pode D, Lazar A, Katz R, Shapiro A. Watchful waiting policy in recurrent TaG1 bladder tumours. Eur Urol. 2006;49:303–7.

    Article  PubMed  Google Scholar 

  20. Oosterlinck W, Bono AV, Mack D, et al. Frequency of positive biopsies after visual disappearance of superficial bladder cancer marker lesions. Eur Urol. 2001;40:515–7.

    Article  PubMed  CAS  Google Scholar 

  21. Soloway MS, Bruck DS, Kim SS. Expectant management of small, recurrent, noninvasive papillary bladder tumours. J Urol. 2003;170:438–41.

    Article  PubMed  Google Scholar 

  22. Gontero P, Bohle A, Malmstrom PU, O’Donnel MA, Oderda M, Sylvester R, Witjes F. The role of bacillus Calmette-Guérin in the treatment of non-muscle-invasive bladder cancer. Eur Urol. 2010;57:410–29.

    Article  PubMed  Google Scholar 

  23. Huncharek M, Kupelnick B. Impact of intravesical chemotherapy versus BCG immunotherapy on recurrence of superficial transitional cell carcinoma of the bladder: metaanalytic reevaluation. Am J Clin Oncol. 2003;26(4):402–7.

    PubMed  CAS  Google Scholar 

  24. Sylvester R, Van der Meijden A, Lamm D. Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials. J Urol. 2002;168:1964–70.

    Article  PubMed  CAS  Google Scholar 

  25. DeVeale B, Brummel T, Seroude L. Immunity and aging: the enemy within? Aging Cell. 2004;3:195–208.

    Article  PubMed  CAS  Google Scholar 

  26. Joudi FN, Smith BJ, O’Donnell MA. Final results from a national multicenter phase II trial of combination bacillus Calmette-Guérin plus interferon α-2B for reducing recurrence of superficial bladder cancer. Urol Oncol. 2006;24:344–8.

    Article  PubMed  CAS  Google Scholar 

  27. Herr HW. Age and outcome of superficial bladder cancer treated with bacilli Calmette-Guérin therapy. Urology. 2007;70:65–8.

    Article  PubMed  Google Scholar 

  28. Yuge K, Kikuchi E, Matsumoto K, Takeda T, Miyajima A, Oya M. Could patient age influence tumor recurrence rate in non-muscle-invasive bladder cancer patients treated with BCG immunotherapy? Jpn J Clin Oncol. 2011;41(4):565–70.

    Article  PubMed  Google Scholar 

  29. Margel D, Alkhateeb SS, Finelli A, Fleshner N. Diminished efficacy of bacilli Calmette-Guérin among elderly patients with nonmuscle invasive bladder cancer. Urology. 2011;78:848–54.

    Article  PubMed  Google Scholar 

  30. Palou J, Angerri O, Segarra J, Caparrós J, Guirado L, Diaz JM, Salvador-Bayarri J, Villavicencio-Mavrich H. Intravesical bacillus Calmette-Guèrin for the treatment of superficial bladder cancer in renal transplant patients. Transplantation. 2003;76(10):1514–6.

    Article  PubMed  Google Scholar 

  31. Yossepowitch O, Eggener S, Bochner B, Donat M, Herr H, Dalbagni G. Safety and efficacy of intravesical bacillus Calmette-Guérin instillations in steroid treated and immunocompromised patients. J Urol. 2006;176:482–5.

    Article  PubMed  Google Scholar 

  32. Palou J, Solsona E, Angulo J, Fernàndez JM, Unda M, Martinez Pineiro L. Retrospective study of different options in the management of non-muscle invasive bladder cancer T1G3: maintenance BCG is here to stay. Eur Urol Suppl. 2011;10(2):149.

    Article  Google Scholar 

  33. Kulkarni GS, Alibhai SMH, Finelli A, Fleshner NE, Jewett MAS, Lopushinsky AM. Cost-effectiveness analysis of immediate radical cystectomy versus intravesical bacillus Calmette-Guerin therapy for high-risk, high-grade (T1G3) bladder cancer. Cancer. 2009;115:5450–9.

    Article  PubMed  Google Scholar 

  34. Colombo R, Salonia A, Leib Z, Pavone-Macaluso M, Engelstein D. Long-term outcomes of a randomized controlled trial comparing thermochemotherapy with mitomycin-C alone as adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC). BJU. 2010;107:912–8.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steven Joniau M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag London

About this chapter

Cite this chapter

Oderda, M., Gontero, P., Joniau, S. (2013). Management of Superficial Bladder Cancer in Elderly Patients. In: Droz, JP., Audisio, R. (eds) Management of Urological Cancers in Older People. Management of Cancer in Older People, vol 1. Springer, London. https://doi.org/10.1007/978-0-85729-999-4_16

Download citation

  • DOI: https://doi.org/10.1007/978-0-85729-999-4_16

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-986-4

  • Online ISBN: 978-0-85729-999-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics