What Is the Role of Cytotoxic Chemotherapy in Advanced Cervical Cancer?
- Alok PantAffiliated withDepartment of Obstetrics and Gynecology, Northwestern Memorial Hospital Email author
- , Nobuyuki SusumuAffiliated withDepartment of Obstetrics and Gynecology, School of Medicine, Keio University
- , Takafumi ToitaAffiliated withDepartment of Radiology, Ryukyu University Hospital
- , Satoru SagaeAffiliated withDepartment of Obstetrics and Gynecology, JR Sapporo Hospital
- , William SmallJr.Affiliated withChairman of Radiation Oncology, Loyola University Medical Center
Cervical cancer is a significant contributor to worldwide morbidity and mortality. Combined chemotherapy and radiation has recently become widely prevalent in the treatment of locally advanced disease. The use of adjuvant chemotherapy following surgery for early-stage disease remains experimental, and the appropriate regimen is not yet clearly defined. Combined chemoradiation following by adjuvant chemotherapy has shown potential benefit in appropriately selected patients, though an increase in toxicity rates has been noted. Neoadjuvant chemotherapy before a surgery is controversial with prior reports showing differing results and continued ongoing trials. Similar to adjuvant chemotherapy, the appropriate regimen remains undefined. Chemotherapy for widely metastatic or for recurrent disease, while still palliative in nature, is undergoing a transformation from regimens with significant toxicity and minimal survival benefit to those regimens with improved side effect profile and steady gains in clinical activity. Numerous international trials are under way trying to improve outcomes in this unfortunate patient population. Targeted therapy for cervical cancer remains in its infancy, but research continues in the laboratory and clinical setting aiming to improve outcomes. International collaboration via cooperative group trials remains the cornerstone for the advancement of care for patients with cervical cancer.
- What Is the Role of Cytotoxic Chemotherapy in Advanced Cervical Cancer?
- Book Title
- Controversies in the Management of Gynecological Cancers
- pp 79-90
- Print ISBN
- Online ISBN
- Springer London
- Copyright Holder
- Springer-Verlag London
- Additional Links
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- Editor Affiliations
- 1. UCL Cancer Institute, University College London
- 2. Radiation Oncology, Leiden University Medical Center
- 3. Royal Women’s Hospital, The University of Melbourne
- Author Affiliations
- 4. Department of Obstetrics and Gynecology, Northwestern Memorial Hospital, 250 East Superior Suite 05-2168, Chicago, IL, 60611, USA
- 5. Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan
- 6. Department of Radiology, Ryukyu University Hospital, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan
- 7. Department of Obstetrics and Gynecology, JR Sapporo Hospital, North 3 East 1, Chuou-ku, Sapporo, Hokkaido, 060-0033, Japan
- 8. Chairman of Radiation Oncology, Loyola University Medical Center, 251 E. Huron Street, Galter LC-178, Chicago, IL, 60611, USA
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