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Drug Interactions and Pharmacogenetics

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Abstract

Drug interaction in cancer chemotherapy is one of the most common phenomena in cancer treatment. Cancer patients often take several medications at the same time, not only for treating their cancer, but also for side effects and other secondary illnesses. The number of comedications increases with age, and drug interactions are critical for elderly patients. Because of this, they can be at high risk for adverse drug interactions and duplicate medications. Consequences of these interactions can range from inactivation of cancer-fighting medications to severe injury or death of the patient. Pharmacogenetics studies the relationship between genetic polymorphisms and individual responses to drugs. In recent years, there has been great progress in our knowledge of the effects of drug-metabolizing enzymes and molecular target genetic polymorphisms on cancer chemotherapy. Pharmacogenetics focuses on the prediction of drug efficacy and toxicity based on a patient’s genetic profile with routinely applicable genetic tests to select the most appropriate medication at optimal doses for each individual patient.

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  1. Department of Pharmacology, Institut Curie-Hôpital René Huguenin, Saint-Cloud, France

    François Lokiec Ph.D., SciD

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  1. , Department of Hematology-Oncology, Centre Hospitalier de Luxembourg, Rue Barble 4, Luxembourg, 1210, Luxembourg

    Mario A. Dicato

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Lokiec, F. (2013). Drug Interactions and Pharmacogenetics. In: Dicato, M. (eds) Side Effects of Medical Cancer Therapy. Springer, London. https://doi.org/10.1007/978-0-85729-787-7_1

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