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mtDNA Mutations in Brain Aging and Neurodegeneration

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Mitochondrial Dysfunction in Neurodegenerative Disorders

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Abstract

The cause of the majority of sporadic cases of neurodegenerative disease is unknown. An attractive hypothesis is that accumulation of mitochondrial DNA (mtDNA) mutations may contribute to the cell loss observed in these diseases. Here we describe some of the data surrounding mtDNA mutations in mitochondrial disease where the most severe symptoms are due to neurodegeneration. We also describe mtDNA mutations in aging and common neurodegenerative disorders with a focus on the consequences of mtDNA mutations and the possible contribution to neurodegeneration.

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Authors and Affiliations

  1. Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK

    Kim Jennifer Krishnan

  2. Centre for Brain Ageing and Vitality, Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK

    Amy Katherine Reeve

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  1. Kim Jennifer Krishnan
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  2. Amy Katherine Reeve
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Correspondence to Kim Jennifer Krishnan .

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Editors and Affiliations

  1. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom

    Amy Katherine Reeve

  2. , Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom

    Kim Jennifer Krishnan

  3. , Department of Cell and Developmental Bio, University College London, London, WC1E 6BT, United Kingdom

    Michael R. Duchen

  4. , Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom

    Doug M Turnbull

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Krishnan, K.J., Reeve, A.K. (2012). mtDNA Mutations in Brain Aging and Neurodegeneration. In: Reeve, A., Krishnan, K., Duchen, M., Turnbull, D. (eds) Mitochondrial Dysfunction in Neurodegenerative Disorders. Springer, London. https://doi.org/10.1007/978-0-85729-701-3_5

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