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Experimental Studies in Face Transplantation: Rodent Model

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The Know-How of Face Transplantation

Abstract

Rodents, especially rats, are the most frequently used animals in composite tissue allotransplantation (CTA) studies. There are several advantages of using rodents in experimental studies especially in transplantation studies. During the past 20 years of our research in the field of CTA transplants, we have designed and developed different craniofacial CTA models in rats testing different immunosuppressive protocols of tolerance induction. These models include full face/scalp transplants, hemiface transplants, composite hemiface/calvarium transplants, rat maxilla allotransplants, composite osteomusculocutaneous hemiface/mandible/tongue-flap transplants, and composite midface allotransplants. These models and the models that will be developed in the future will provide the scientific foundation for future success in CTA transplantation in the clinical setting.

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Abbreviations

CsA:

cyclosporine A

CTA:

composite tissue allotransplantation

MEP:

motor evoked potentials

MHC:

major histocompatibility complex

SSEP:

somatosensory evoked potentials

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Authors and Affiliations

  1. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Maria Z. Siemionow

Authors
  1. Maria Z. Siemionow
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  2. Fatih Zor
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Corresponding author

Correspondence to Maria Z. Siemionow .

Editor information

Editors and Affiliations

  1. Dept. Plastic Surgery A/60, Cleveland Clinic Foundation, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Maria Z. Siemionow

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© 2011 Springer London

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Siemionow, M.Z., Zor, F. (2011). Experimental Studies in Face Transplantation: Rodent Model. In: Siemionow, M. (eds) The Know-How of Face Transplantation. Springer, London. https://doi.org/10.1007/978-0-85729-253-7_4

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  • DOI: https://doi.org/10.1007/978-0-85729-253-7_4

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-252-0

  • Online ISBN: 978-0-85729-253-7

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