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Clinicogenetic and Pathologic Characteristics of CADASIL

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Abstract

CADASIL is the most common inherited monogenic disorder causing stroke. It is becoming increasingly recognized across many ancestral groups. This chapter presents the salient features of the disorder to assist those unfamiliar with CADASIL to recognize the disorder.

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Acknowledgments

We would like to thank all those who have contributed to our research, particularly the patients and families who donated DNA samples for this work. We would like to thank Dr. Eoin Kavanagh (Consultant Radiologist, Mater Misericordiae Hospital, Dublin) for providing the MRI images. OAR is a recipient of a James and Ester King Foundation New Investigator Award, Florida State. OAR is also funded by the American Heart Association (AHA) and the Myron and Jane Hanley Award in Stroke research. For further details on our research in cerebrovascular disease, please visit our Website: http://mayoresearch.mayo.edu/mayo/research/ross_lab/

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Authors and Affiliations

  1. Department of Neurology, Dublin Neurological Institute, 57 Eccles Street, Dublin 7, Ireland

    Kinley A. Roberts MB, BAO Bch

  2. Department of Neurology, Dublin Neurological Institute, Mater Misericordiae University Hospital, Dublin 7, Ireland

    Killian E. T. O’Rourke M.D., M.Sc., MRCPi

  3. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

    Owen A. Ross Ph.D.

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  1. Kinley A. Roberts MB, BAO Bch
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  2. Killian E. T. O’Rourke M.D., M.Sc., MRCPi
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  3. Owen A. Ross Ph.D.
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Correspondence to Kinley A. Roberts MB, BAO Bch .

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Editors and Affiliations

  1. Imperial College London & Hammersmith Ho, Fulham Palace Road, London, W6 8RF, United Kingdom

    Pankaj Sharma

  2. , Mayo Clinic Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, 32224, Florida, USA

    James F Meschia

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Roberts, K.A., O’Rourke, K.E.T., Ross, O.A. (2013). Clinicogenetic and Pathologic Characteristics of CADASIL. In: Sharma, P., Meschia, J. (eds) Stroke Genetics. Springer, London. https://doi.org/10.1007/978-0-85729-209-4_6

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