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Advanced Photonic Structures for Biological and Chemical Detection pp 377–393Cite as

Label-Free Biosensing with the Optofluidic Ring Resonator

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Part of the book series: Integrated Analytical Systems ((ANASYS))

Abstract

The optofluidic ring resonator (OFRR) is a label-free refractive index biosensing platform that uses a glass capillary as a microfluidic sample delivery mechanism with an inherently integrated optical ring resonator. The device delivers molecular detection limits on par with the top-performing commercial label-free sensing technologies while reducing cost and complexity compared with fluorescence-based biosensing techniques as well as other label-free devices. The OFRR has been shown to quantify target molecules in a sample through specific biomolecular recognition events at the surface of the capillary. Examples presented here include protein detection, DNA sequence detection, and pathogen detection. The design of the OFRR makes it well-suited for integration into a lab-on-a-chip platform that will have significant implications for the diagnosis and understanding of disease.

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Acknowledgment

This work is supported by the Wallace H. Coulter Foundation Early Career Award and the NIH (1K25 EB006011).

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Authors and Affiliations

  1. Department of Biological Engineering, University of Missouri, Columbia, MO, 65211, USA

    Hongying Zhu, Jonathan D. Suter & Xudong Fan

Authors
  1. Ian M. White
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  2. Hongying Zhu
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  3. Jonathan D. Suter
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  4. Xudong Fan
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Editor information

Editors and Affiliations

  1. Dept. Biological Engineering, University of Missouri, 240D Bond Life Sciences Center, 1201 E. Rollins St., 65211, Columbia, MO, USA

    Xudong Fan

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White, I.M., Zhu, H., Suter, J.D., Fan, X. (2009). Label-Free Biosensing with the Optofluidic Ring Resonator. In: Fan, X. (eds) Advanced Photonic Structures for Biological and Chemical Detection. Integrated Analytical Systems. Springer, New York, NY. https://doi.org/10.1007/978-0-387-98063-8_14

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