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Antimicrobial Resistance in Gram-Negative Bacteria from Developing Countries

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Abstract

Antimicrobial resistance is a worldwide problem, with severe implications for developing countries, where a high infectious disease burden coexists with rapid emergence and spread of antimicrobial resistance. Furthermore, cost constrains the broader use of newer, more expensive therapeutic agents and the application of appropriate infection control measures. In the present chapter, we address the main antimicrobial resistance problems affecting hospital- and community-acquired bacterial infections. The majority of the data reviewed here was obtained from multinational surveillance programs and the chapter is structured according to organisms or organism groups.

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References

  • Andrade, S. S., Jones, R. N., Gales, A. C., and Sader, H. S. 2003. “Increasing prevalence of antimicrobial resistance among Pseudomonas aeruginosa isolates in Latin American medical centres: 5 year report of the SENTRY Antimicrobial Surveillance Program (1997–2001)”. Journal of Antimicrobial Chemotherapy 52:140–141.

    Article  CAS  PubMed  Google Scholar 

  • Baraniak, A., Fiett, J., Sulikowska, A., Hryniewicz, W., and Gniadkowski, M. 2002. “Countrywide spread of CTX-M-3 extended-spectrum β-lactamase-producing microorganisms of the family Enterobacteriaceae in Poland.” Antimicrobial Agents and Chemotherapy 46:151–159.

    Article  CAS  PubMed  Google Scholar 

  • Bell, J. M., Turnidge, J. D., and Jones, R. N. 2003. “Prevalence of extended-spectrum b-lactamase-producing Enterobacter cloacae in the Asia-Pacific region: Results from the SENTRY Antimicrobial Surveillance Program, 1998 to 2001.” Antimicrobial Agents and Chemotherapy 47:3989–3993.

    Article  CAS  PubMed  Google Scholar 

  • Bell, J. M., Turnidge, J. D., Walters, L. J., and Jones, R. N. 2007. “Emergence and widespread dissemination of OXA-23, -24 and -58 carbapenemases among Acinetobacter spp. in Asia-Pacific Surveillance Program (2006)”, Abstract C2-1510a. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, IL, 228.

    Google Scholar 

  • Biedenbach, D. J., Toleman, M., Walsh, T. R., and Jones, R. N. 2006. “Analysis of Salmonella spp. with resistance to extended-spectrum cephalosporins and fluoroquinolones isolated in North America and Latin America: report from the SENTRY Antimicrobial Surveillance Program (1997–2004).” Diagnostic Microbiology and Infectious Diseases 54:13–21.

    Article  CAS  Google Scholar 

  • Brink, A., Moolman, J., da Silva, M. C., and Botha, M. 2007. “Antimicrobial susceptibility profile of selected bacteraemic pathogens from private institutions in South Africa.” South African Medical Journal 97:273–279.

    CAS  PubMed  Google Scholar 

  • Castanheira, M., Bell, J. M., Jones, R. N., Mathai, D., and Turnidge, J. D. 2008. “High carbapenem resistance among Pseudomonas aeruginosa from India: A national epidemic of multiple metallo-β-lactamase clones (VIM-2, -5, -6, -11 and new VIM-18)”, Abstract P900. 18th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain.

    Google Scholar 

  • Castanheira, M., Bell, J. M., Turnidge, J. D., Mendes, R. E., Sader, H. S., and Jones, R. N. 2007a. “Dissemination and genetic context analysis of bla VIM-6 among Pseudomonas aeruginosa in Asia-Pacific Nations”, Abstract C1-109a. 47th International Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, IL.

    Google Scholar 

  • Castanheira, M., Mendes, R. E., Picao, R. C., Pinto, F. P., Machado, A. M. O., Walsh, T. R., and Gales, A. C. 2006. “Genetic analysis of a multidrug-resistant (MDR) Enterobacter cloacae producing IMP-1 metallo-b-lactamase (MBL), Abstract C1-63.” 46th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, 72.

    Google Scholar 

  • Castanheira, M., Pereira, A. S., Nicoletti, A. G., Pignatari, A. C., Barth, A. L., and Gales, A. C. 2007b. “First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America.” Antimicrobial Agents and Chemotherapy. 51:1527–1529.

    Google Scholar 

  • CDC. 2003. Centers for Disease Control and Prevention: National Center for Infectious Disease and World Health Organization: Department of Communicable Disease Surveillance and Response. Manual for the laboratory identification and antimicrobial susceptibility testing of bacterial pathogens of public health importance in the developing world: Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, Salmonella serotype Typhi, Shigella and Vibrio cholerae. Chapter IV P 29–43. WHO/CDS/CSR/RMD/2003.6. Available from http://www.who.int/csr/resources/publications/drugresist/WHO_CDS_CSR_RMD_2003_6/3n/.

  • Chau, T. T., Campbell, J. I., Galindo, C. M., Van Minh Hoang, N., Diep, T. S., Nga, T. T., Van Vinh Chau, N., Tuan, P. Q., Page, A. L., Ochiai, R. L., Schultsz, C., Wain, J., Bhutta, Z. A., Parry, C. M., Bhattacharya, S. K., Dutta, S., Agtini, M., Dong, B., Honghui, Y., Anh, D. D., Canh do, G., Naheed, A., Albert, M. J., Phetsouvanh, R., Newton, P. N., Basnyat, B., Arjyal, A., La, T. T., Rang, N. N., Phuong le, T., Van Be Bay, P., von Seidlein, L., Dougan, G., Clemens, J. D., Vinh, H., Hien, T. T., Chinh, N. T., Acosta, C. J., Farrar, J., and Dolecek, C. 2007. “Antimicrobial drug resistance of Salmonella enterica Serovar Typhi in Asia and molecular mechanism of reduced susceptibility to the fluoroquinolones.” Antimicrobial Agents and Chemotherapy 51:4315–4323.

    Article  PubMed  Google Scholar 

  • Crawford, S. A., Fiebelkorn, K. R., Patterson, J. E., Jorgensen, and J. H. 2005. “International clone of Neisseria meningitidis serogroup A with tetracycline resistance due to tet(B).” Antimicrobial Agents and Chemotherapy 49:1198–1200.

    Article  CAS  PubMed  Google Scholar 

  • Daoud, Z., Moubareck, C., Hakime, N., and Doucet-Populaire, F. 2006. “Extended-spectrum β-lactamase producing Enterobacteriaceae in Lebanese ICU patients: Epidemiology and patterns of resistance.” The Journal of General and Applied Microbiology 52:169–178.

    Article  CAS  PubMed  Google Scholar 

  • Dillon, J. A., Ruben, M., Li, H., Borthagaray, G., Marquez, C., Fiorito, S., Galarza, P., Portilla, J. L., Leon, L., Agudelo, C. I., Sanabria, O. M., Maldonado, A., and Prabhakar, P. 2006. “Challenges in the control of gonorrhea in South America and the Caribbean: monitoring the development of resistance to antibiotics.” Sexually Transmitted Diseases 33:87–95.

    Article  PubMed  Google Scholar 

  • Dromigny, J. A., Ndoye, B., Macondo, E. A., Nabeth, P., Siby, T., and Perrier-Gros-Claude, J. D. 2003. “Increasing prevalence of antimicrobial resistance among Enterobacteriaceae uropathogens in Dakar, Senegal: A multicenter study.” Diagnostic Microbiology and Infectious Diseases 47:595–600.

    Article  CAS  Google Scholar 

  • Galanis, E., Lo Fo Wong, D. M., Patrick, M. E., Binsztein, N., Cieslik, A., Chalermchikit, T., Aidara-Kane, A., Ellis, A., Angulo, F. J., and Wegener, H. C. 2006. “Web-based surveillance and global Salmonella distribution, 2000–2002.” Emerging Infectious Diseases 12:381–388.

    PubMed  Google Scholar 

  • Gales, A. C., Jones, R. N., Gordon, K. A., Sader, H. S., Wilke, W. W., Beach, M. L., Pfaller, M. A., and Doern, G. V. 2000. “Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: Report from the second year of the SENTRY Antimicrobial Surveillance Program (1998).” Journal Antimicrobial Chemotherapy 45:295–303.

    Article  CAS  Google Scholar 

  • Gales, A. C., Sader, H. S., and Jones, R. N. 2002a. “Urinary tract infection trends in Latin American hospitals: Report from the SENTRY antimicrobial surveillance program (1997–2000).” Diagnostic Microbiology and Infectious Diseases 44:289–299.

    Google Scholar 

  • Gales, A. C., Sader, H. S., Mendes, R. E., and Jones, R. N. 2002b. “Salmonella spp. isolates causing bloodstream infections in Latin America: Report of antimicrobial activity from the SENTRY Antimicrobial Surveillance Program (1997–2000).” Diagnostic Microbiology and Infectious Diseases 44:313–318.

    Google Scholar 

  • Jorgensen, J. H., Crawford, S. A., and Fiebelkorn, K. R. 2005. “Susceptibility of Neisseria meningitidis to 16 antimicrobial agents and characterization of resistance mechanisms affecting some agents.” Journal of Clinical Microbiology 43:3162–3171.

    Article  CAS  PubMed  Google Scholar 

  • Kotloff, K. L., Winickoff, J. P., Ivanoff, B., Clemens, J. D., Swerdlow, D. L., Sansonetti, P. J., Adak, G. K., and Levine, M. M. 1999. “Global burden of Shigella infections: Implications for vaccine development and implementation of control strategies.” Bulletin of the World Health Organization 77:651–666.

    CAS  PubMed  Google Scholar 

  • Lincopan, N., McCulloch, J. A., Reinert, C., Cassettari, V. C., Gales, A. C., and Mamizuka, E. M. 2005. “First isolation of metallo-β-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil.” Journal of Clinical Microbiology 43:516–519.

    Article  CAS  PubMed  Google Scholar 

  • Manchanda, V., and Bhalla, P. 2006. “Emergence of non-ceftriaxone-susceptible Neisseria meningitidis in India.” Journal of Clinical Microbiology 44:4290–4291.

    Article  PubMed  Google Scholar 

  • Melano, R., Corso, A., Petroni, A., Centron, D., Orman, B., Pereyra, A., Moreno, N., and Galas, M. 2003. “Multiple antibiotic-resistance mechanisms including a novel combination of extended-spectrum beta-lactamases in a Klebsiella pneumoniae clinical strain isolated in Argentina.” Journal of Antimicrobial Chemotherapy 52:36–42.

    Article  CAS  PubMed  Google Scholar 

  • Mendes, R. E., Bell, J. M., Turnidge, J. D., Yang, Q., Yu, Y., Sun, Z., and Jones, R. N. 2008. “Carbapenem-resistant isolates of Klebsiella pneumoniae in China and detection of a conjugative plasmid (bla KPC-2 + qnrB4) and a bla IMP-4.” Antimicrobial Agents and Chemotherapy 52:798–799.

    Article  CAS  PubMed  Google Scholar 

  • Monteiro, J., Henriques, A. P. C., Santos, A. F., Matos, D. G. C., Perano, G., Asensi, M. D., and Gales, A. C. 2007. Carbapenem-resistant Klebsiella pneumoniae outbreak: Emergence of KPC-2-producing strains in Brazil, Abstr C2-1929. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, IL, 141.

    Google Scholar 

  • Okeke, I. N., Laxminarayan, R., Bhutta, Z. A., Duse, A. G., Jenkins, P., O'Brien, T. F., Pablos-Mendez, A., and Klugman, K. P. 2005. “Antimicrobial resistance in developing countries. Part I: Recent trends and current status.” The Lancet Infectious Diseases 5:481–493.

    Article  CAS  PubMed  Google Scholar 

  • Pallecchi, L., Malossi, M., Mantella, A., Gotuzzo, E., Trigoso, C., Bartoloni, A., Paradisi, F., Kronvall, G., and Rossolini, G. M. 2004. “Detection of CTX-M-type β-lactamase genes in fecal Escherichia coli isolates from healthy children in Bolivia and Peru.” Antimicrobial Agents and Chemotherapy 48:4556–4561.

    Article  CAS  PubMed  Google Scholar 

  • Peirano, G., Souza, F. S., and Rodrigues, D. P. 2006. “Frequency of serovars and antimicrobial resistance in Shigella spp. from Brazil.” Memórias do Instituto Oswaldo Cruz 101:245–250.

    Article  PubMed  Google Scholar 

  • Poirel, L., Pitout, J. D., and Nordmann, P. 2007. “Carbapenemases: Molecular diversity and clinical consequences.” Future Microbiology 2:501–512.

    Article  CAS  PubMed  Google Scholar 

  • Rao, P. S., Rajashekar, V., Varghese, G. K., and Shivananda, P. G. 1993. “Emergence of multidrug-resistant Salmonella typhi in rural southern India.” American Journal of Tropical Medicine and Hygiene 48:108–111.

    CAS  PubMed  Google Scholar 

  • Rossi, F., Baquero, F., Hsueh, P. R., Paterson, D. L., Bochicchio, G. V., Snyder, T. A., Satishchandran, V., McCarroll, K., DiNubile, M. J., and Chow, J. W. 2006. “In vitro susceptibilities of aerobic and facultatively anaerobic Gram-negative bacilli isolated from patients with intra-abdominal infections worldwide: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends).” Journal of Antimicrobial Chemotherapy 58:205–210.

    Article  CAS  PubMed  Google Scholar 

  • Sader, H. S., Bell, J. M., Jones, R. N., Fritsche, T. R., and Turnidge, J. D. 2007. Spectrum and potency of tigecycline tested against non-enteric Gram-negative bacilli collected across the Asia-Pacific region (2006), Abstract 531. 45th Infectious Disease Society of America (IDSA), San Diego, CA, 160–161.

    Google Scholar 

  • Sader, H. S., Castanheira, M., Mendes, R. E., Toleman, M., Walsh, T. R., and Jones, R. N. 2005. “Dissemination and diversity of metallo-β-lactamases in Latin America: Report from the SENTRY Antimicrobial Surveillance Program.” International Journal of Antimicrobial Agents 25:57–61.

    Article  CAS  PubMed  Google Scholar 

  • Sader, H. S., Jones, R. N., Andrade-Baiocchi, S., and Biedenbach, D. J. 2002. “Four-year evaluation of frequency of occurrence and antimicrobial susceptibility patterns of bacteria from bloodstream infections in Latin American medical centers.” Diagnostic Microbiology and Infectious Diseases 44:273–280.

    Article  Google Scholar 

  • Stephens, D. S., Greenwood, B., and Brandtzaeg, P. 2007. “Epidemic meningitis, meningococcaemia, and Neisseria meningitidis.” Lancet 369:2196–2210.

    Article  PubMed  Google Scholar 

  • Streit, J. M., Jones, R. N., Toleman, M. A., Stratchounski, L. S., and Fritsche, T. R. 2006. “Prevalence and antimicrobial susceptibility patterns among gastroenteritis-causing pathogens recovered in Europe and Latin America and Salmonella isolates recovered from bloodstream infections in North America and Latin America: Report from the SENTRY Antimicrobial Surveillance Program (2003).” International Journal of Antimicrobial Agents 27:378–386.

    Article  Google Scholar 

  • Talukder, K. A., Khajanchi, B. K., Islam, M. A., Dutta, D. K., Islam, Z., Safa, A., Khan, G. Y., Alam, K., Hossain, M. A., Malla, S., Niyogi, S. K., Rahman, M., Watanabe, H., Nair, G. B., and Sack, D. A. 2004. “Genetic relatedness of ciprofloxacin-resistant Shigella dysenteriae type 1 strains isolated in south Asia.” Journal of Antimicrobial Chemotherapy 54:730–734.

    Article  CAS  PubMed  Google Scholar 

  • Taneja, N. 2007. Changing epidemiology of shigellosis and emergence of ciprofloxacin-resistant Shigellae in India. Journal of Clinical Microbiology 45:678–679.

    Article  PubMed  Google Scholar 

  • Tapsall, J. W. 2001. Antimicrobial resistance in Neisseria gonorrhoeae. Available at: http://www.who.int/drugresistance/Antimicrobial_resistance_in_Neisseria_gonorrhoeae.pdf. Geneve, Switzerland: Department of Communicable Diseases Surveillance and Response.

  • Van Dyck, E., Karita, E., Abdellati, S., Dirk, V. H., Ngabonziza, M., Lafort, Y., and Laga, M. 2001. “Antimicrobial susceptibilities of Neisseria gonorrhoeae in Kigali, Rwanda, and trends of resistance between 1986 and 2000.” Sexually Transmitted Diseases 28:539–545.

    Article  PubMed  Google Scholar 

  • Villegas, M. V., Lolans, K., Correa, A., Suarez, C. J., Lopez, J. A., Vallejo, M., and Quinn, J. P. 2006. First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America. Antimicrobial Agents and Chemotherapy 50:2880–2882.

    Article  CAS  PubMed  Google Scholar 

  • Walther-Rasmussen J, and Høiby N. 2006. OXA-type carbapenemases. Journal of Antimicrobial Chemotherapy 57:373–83.

    Article  CAS  PubMed  Google Scholar 

  • Wang, H., and Chen, M. 2005. “Surveillance for antimicrobial resistance among clinical isolates of Gram-negative bacteria from intensive care unit patients in China, 1996 to 2002.” Diagnostic Microbiology and Infectious Diseases 51:201–208.

    Article  Google Scholar 

  • WHO. 2006. World Health Organization. “Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 2004.” Communicable Diseases Intelligence 30: 129–132.

    Google Scholar 

  • WHO Global Salm-Surv. 2007. Progress report (2000–2005): Building capacity for laboratory-based foodborne disease surveillance and outbreak detection and response (http://www.who.int/salmsurv/links/GSSProgressReport2005.pdf). Accessed November 2007.

  • Wu, J. J., Ko, W. C., Tsai, S. H., and Yan, J. J. 2007. “Prevalence of plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital.” Antimicrobial Agents and Chemotherapy 51:1223–1227.

    Article  CAS  PubMed  Google Scholar 

  • Yildirim, I., Ceyhan, M., Gur, D., Mugnaioli, C., and Rossolini, G. M. 2007. “First detection of VIM-1 type metallo-β-lactamase in a multidrug-resistant Klebsiella pneumoniae clinical isolate from Turkey also producing the CTX-M-15 extended-spectrum β-lactamase.” Journal of Chemotherapy 19:467–468.

    CAS  PubMed  Google Scholar 

  • Yuksel, S., Ozturk, B., Kavaz, A., Ozcakar, Z. B., Acar, B., Guriz, H., Aysev, D., Ekim, M., and Yalcinkaya, F. 2006. “Antibiotic resistance of urinary tract pathogens and evaluation of empirical treatment in Turkish children with urinary tract infections.” International Journal of Antimicrobial Agents 28:413–416.

    Article  PubMed  Google Scholar 

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Correspondence to Soraya Sgambatti de Andrade .

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de Andrade, S.S., Gales, A.C., Sader, H.S. (2010). Antimicrobial Resistance in Gram-Negative Bacteria from Developing Countries. In: Sosa, A., Byarugaba, D., Amábile-Cuevas, C., Hsueh, PR., Kariuki, S., Okeke, I. (eds) Antimicrobial Resistance in Developing Countries. Springer, New York, NY. https://doi.org/10.1007/978-0-387-89370-9_14

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