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Molecular Basis of Hematopoiesis pp 215–230Cite as

Leukemic Stem Cells: New Therapeutic Targets?

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Abstract

An emerging concept in cancer biology is that a subset of cancer cells among the heterogeneous cell mass that constitutes the tumor may drive the growth of the tumor. This so-called cancer stem cell (CSC) shared some main features with normal stem cells. These include self-renewal, differentiation into the cell types of the original cancer and potent tumor formation. Despite the clear importance of CSCs in the genesis and perpetuation of cancers, little is currently known about the biological and molecular properties that make CSCs distinct from normal stem cells, the developmental/cellular origin of CSCs, the mechanisms responsible for their emergence in the course of the disease, and identification of candidate molecular targets for therapeutic intervention. This report will focus more specifically on the blood-related cancer leukemia, which was the first disease where human CSCs, or leukemic stem cells (LSCs), were isolated. In this chapter we will summarize our knowledge of LSCs notably in acute myeloid leukemia (AML) and will discuss different issues that are arising in trying to eradicate these cells.

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Authors and Affiliations

  1. Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX UK

    Dominique Bonnet

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  1. Dominique Bonnet
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Correspondence to Dominique Bonnet .

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  1. Department of Medicine, MC2115, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637

    Amittha Wickrema

  2. Department of Pathology, MC1089, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637

    Barbara Kee

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Bonnet, D. (2009). Leukemic Stem Cells: New Therapeutic Targets?. In: Wickrema, A., Kee, B. (eds) Molecular Basis of Hematopoiesis. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85816-6_10

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