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Tropomyosin pp 27–42Cite as

Tropomyosin Exons as Models for Alternative Splicing

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 644))

Abstract

Three of the four mammalian tropomyosin (Tm) genes are alternatively spliced, most commonly by mutually exclusive selection from pairs of internal or 3′ end exons. Alternative splicing events in the TPM1, 2 and 3 genes have been analysed experimentally in various levels of detail. In particular, mutually exclusive exon pairs in the βTm (TPM2) and αTm (TPM1) genes are among the most intensively studied models for striated and smooth muscle specific alternative splicing, respectively. Analysis of these model systems has provided important insights into general mechanisms and strategies of splicing regulation.

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Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK

    Clare Gooding & Christopher W. J. Smith

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  1. Clare Gooding
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  2. Christopher W. J. Smith
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Correspondence to Christopher W. J. Smith .

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  1. Oncology Research Unit, Department of Pharmacology School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Peter Gunning PhD

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Gooding, C., Smith, C.W.J. (2008). Tropomyosin Exons as Models for Alternative Splicing. In: Gunning, P. (eds) Tropomyosin. Advances in Experimental Medicine and Biology, vol 644. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85766-4_3

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