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Tropomyosin pp 168–186Cite as

Tropomyosin Function in Yeast

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 644))

Abstract

Tropomyosins were discovered as regulators of actomyosin contractility in muscle cells, making yeasts and other fungi seem unlikely to harbor such proteins. Fungal cells are encased in a rigid cell wall and do not engage in the same sorts of contractile shape changes of animal cells. However, discovery of actin and myosin in yeast raised the possibility for a role for tropomyosin in regulating their interaction. [1,2], Through abiochemical search, fungal tropomyosins were identified with strong similarities to their animal counterparts in terms of protein structure and physical properties. Two particular fungi, the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe have provided powerful genetic systems for studying tropomyosins in nonmetazoans. In these yeasts, tropomyosins associate with subsets of actin filamentous structures. Mutational studies of tropomyosin genes and biochemical assyas of purified proteins point to roles for these proteins as factors that stabilize actin filaments, promote actin-based structures of particular architecture and help maintain distinct biochemical identities among different filament populations. Tropomyosin-enriched filaments are the cytoskeletal structures that promote the major cell shape changes of these organisms: polarized growth and cell division.

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  1. Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA

    David Pruyne

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  1. Oncology Research Unit, Department of Pharmacology School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Peter Gunning PhD

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Pruyne, D. (2008). Tropomyosin Function in Yeast. In: Gunning, P. (eds) Tropomyosin. Advances in Experimental Medicine and Biology, vol 644. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85766-4_14

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